A5089893713- Cancer Genomics and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Cancer, Lipids, and Metabolism
- Bioinformatics and Genomic Networks
- Lipoproteins and Cardiovascular Health
- PI3K/AKT/mTOR signaling in cancer
- Computational Drug Discovery Methods
- Biological Research and Disease Studies
- Cytokine Signaling Pathways and Interactions
- Renal cell carcinoma treatment
- Estrogen and related hormone effects
- Microbial Natural Products and Biosynthesis
- Biochemical and Molecular Research
- Protein Kinase Regulation and GTPase Signaling
- Renal and related cancers
- 14-3-3 protein interactions
- Cancer, Hypoxia, and Metabolism
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Cancer therapeutics and mechanisms
- Glycosylation and Glycoproteins Research
- Cancer Cells and Metastasis
- Synthesis and biological activity
- Melanoma and MAPK Pathways
University of St Andrews
2015-2025
University of Southern California
2022-2025
Western General Hospital
1998-2023
University of Edinburgh
1987-2023
University of California, Los Angeles
2018-2021
Princess Margaret Cancer Centre
2013-2020
University Health Network
2011-2020
St. Andrews University
2016
Ontario Institute for Cancer Research
2011-2014
University of Basel
2012-2014
Abstract Viruses hijack host cell metabolism to acquire the building blocks required for replication. Understanding how SARS-CoV-2 alters may lead potential treatments COVID-19. Here we profile metabolic changes conferred by infection in kidney epithelial cells and lung air-liquid interface (ALI) cultures, show that increases glucose carbon entry into TCA cycle via increased pyruvate carboxylase expression. also reduces oxidative glutamine while maintaining reductive carboxylation....
To identify therapeutic targets and prognostic markers for basal breast cancers, cancer cell lines were subjected to mass spectrometry-based profiling of protein tyrosine phosphorylation events. This revealed that luminal cells exhibit distinct signatures depend on pathway activation as well expression. Basal are characterized by elevated Met, Lyn, EphA2, epidermal growth factor receptor (EGFR), FAK, Src family kinase (SFK) substrates such p130Cas. SFKs exert a prominent role in these cells,...
Resistance to targeted cancer therapies such as trastuzumab is a frequent clinical problem not solely because of insufficient expression HER2 receptor but also the overriding activation states cell signaling pathways. Systems biology approaches lend themselves rapid in silico testing factors, which may confer resistance therapies. Inthis study, we aimed develop new kinetic model that could be interrogated predict tyrosine kinase (RTK) inhibitor and directly test predictions vitro samples....
The majority of ovarian cancer patients are treated with platinum-based chemotherapy, but the emergence resistance to such chemotherapy severely limits its overall effectiveness. We have shown that development this treatment can modify cell signaling responses in a model system wherein cisplatin has altered responsiveness ligands erbB receptor family. A cisplatin-resistant carcinoma line PE01CDDP was derived from parent PE01 by exposure increasing concentrations cisplatin, eventually...
New therapies are urgently needed for hematologic malignancies, especially in patients with relapsed acute myelogenous leukemia (AML) and multiple myeloma. We others have previously shown that FDA-approved statins, which used to control hypercholesterolemia target the mevalonate pathway (MVA), can trigger tumor-selective apoptosis. Our goal was identify other drugs synergize statins further enhance anticancer activity of vivo. Using a screen composed FDA approved drugs, we identified...
// Carol Ward 1 , James Meehan Peter Mullen 2 Claudiu Supuran 3 J. Michael Dixon 4 Jeremy S. Thomas 5 Jean-Yves Winum 6 Philippe Lambin 7 Ludwig Dubois Nanda-Kumar Pavathaneni 6, Edward Jarman Lorna Renshaw InHwa Um Charlene Kay David Harrison Ian H. Kunkler 8 Simon P. Langdon Division of Pathology, Institute Genetics and Molecular Medicine, University Edinburgh, United Kingdom School St Andrews, North Haugh, Università degli Studi di Firenze, Polo Scientifico, Laboratorio Chimica...
The statin family of cholesterol-lowering drugs has been shown to induce tumor-specific apoptosis by inhibiting the rate-limiting enzyme mevalonate (MVA) pathway, HMG-CoA reductase (HMGCR). Accumulating evidence suggests that use may delay prostate cancer (PCa) progression in a subset patients; however, determinants drug sensitivity PCa remain unclear. Our goal was identify molecular features statin-sensitive and opportunities potentiate statin-induced cell death.Deregulation HMGCR...
// Aleksandra A. Pandyra 1, 2, 4 , Peter J. Mullen 1 Carolyn Goard 2 Elke Ericson 3, 5 Piyush Sharma Manpreet Kalkat Rosemary Yu Janice T. Pong Kevin R. Brown 3 Traver Hart Marinella Gebbia Karl S. Lang Guri Giaever 6 Corey Nislow Jason Moffat Linda Z. Penn Princess Margaret Cancer Centre, Toronto, ON, Canada Department of Medical Biophysics, University Donnelly Centre and Banting & Best Research, Institute Immunology, Faculty, Duisburg-Essen, Essen, Germany Now located at AstraZeneca...
The statin family of drugs preferentially triggers tumor cell apoptosis by depleting mevalonate pathway metabolites farnesyl pyrophosphate (FPP) and geranylgeranyl (GGPP), which are used for protein prenylation, including the oncoproteins RAS superfamily. However, accumulating data indicate that activation superfamily poor biomarkers sensitivity, mechanism statin-induced tumor-specific remains unclear. Here we demonstrate cancer death triggered statins can be uncoupled from prenylation...
Hypoxic cancer cells exhibit resistance to many therapies. This study compared the therapeutic effect of targeting pH regulatory proteins (CAIX, NHE1 and V-ATPase) that permit adapt hypoxic conditions, using both 2D 3D culture models. Drugs CAIX, V-ATPase exhibited anti-proliferative effects in MCF-7, MDA-MB-231 HBL-100 breast cell lines 2D. Protein gene expression analysis showed CAIX was most hypoxia-inducible protein 3 targets. However, differed between lines. difference hypoxia...
The natural polyphenol myricetin induces cell cycle arrest and apoptosis in preclinical cancer models. We hypothesised that myricetin-derived flavonoids with enhanced redox properties, improved uptake mitochondrial targeting might have increased potential as antitumour agents. studied the effect of a second-generation flavonoid analogue Oncamex panel seven breast lines, applying western blotting, gene expression analysis, fluorescence microscopy immunohistochemistry xenograft tissue to...
Abstract Background Statins inhibit HMG-CoA reductase, the rate-limiting enzyme of mevalonate pathway. Epidemiological and pre-clinical evidence support an association between statin use delayed prostate cancer (PCa) progression. Here, we evaluated effects neoadjuvant fluvastatin treatment on markers cell proliferation apoptosis in men with localized PCa. Methods Thirty-three were treated daily 80 mg for 4–12 weeks a single-arm window-of-opportunity study diagnosis PCa radical prostatectomy...
Nine hundred and sixty‐eight bird species, covering all orders, were studied in search of distinctive ultraviolet reflections. All species the following orders completely surveyed: Struthioniformes, Tinamiformes, Craciformes, Turniciformes, Galbuliformes, Upupiformes, Coliiformes, Apodiformes Musophagiformes. The coloured plumage regions particular exhibited high proportions UV‐reflecting feathers. Bird with which are believed to possess VS (violet‐sensitive) cone types mostly had their UV...
Abstract Purpose: The aim of this study was to investigate the antitumor effects HER2-directed combination therapy in ovarian cancer xenograft models evaluate their potential. combinations trastuzumab and pertuzumab, aromatase inhibitor were investigated. Experimental Design: trastuzumab, letrozole on growth response, apoptosis, morphology, gene protein expression evaluated SKOV3 cell line a panel five human xenografts derived directly from clinical specimens. Results: antibodies showed...