A5103275245- Breast Cancer Treatment Studies
- Cell death mechanisms and regulation
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Enzyme function and inhibition
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Cells and Metastasis
- NF-κB Signaling Pathways
- Radiopharmaceutical Chemistry and Applications
- Cancer-related Molecular Pathways
- Synthesis and Catalytic Reactions
- Estrogen and related hormone effects
- Phagocytosis and Immune Regulation
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Chemical Reactions and Isotopes
- Cell Adhesion Molecules Research
- Cancer Research and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- 3D Printing in Biomedical Research
- Phytochemicals and Antioxidant Activities
- Immune cells in cancer
- Inflammasome and immune disorders
- RNA modifications and cancer
- Cholinesterase and Neurodegenerative Diseases
University of Michigan
2023
University of Edinburgh
2011-2020
Edinburgh Cancer Research
2017-2020
Institute of Genetics and Cancer
2012-2019
Roslin Institute
2018-2019
Creative Research Enterprises (United States)
2018
Western General Hospital
2012-2017
Hays Medical Center
2016
Truman Medical Center
2016
University of Kansas Medical Center
2016
The phase III, randomized, placebo-controlled Sequential Tarceva in Unresectable NSCLC (SATURN; BO18192) study found that erlotinib maintenance therapy extended progression-free survival (PFS) and overall patients with advanced non-small-cell lung cancer (NSCLC) who had nonprogressive disease following first-line platinum-doublet chemotherapy. This included prospective analysis of the prognostic predictive value several biomarkers.Mandatory diagnostic tumor specimens were collected before...
During beneficial inflammation, potentially tissue-damaging granulocytes undergo apoptosis before being cleared by phagocytes in a non-phlogistic manner. Here we show that the rate of constitutive human neutrophils and eosinophils is greatly accelerated both rapid concentration-dependent manner fungal metabolite gliotoxin, but not its inactive analog methylthiogliotoxin. This induction was abolished caspase inhibitor zVAD-fmk, correlated with inhibition nuclear factor-kappa B (NF-κB),...
// Chrysi Xintaropoulou 1 , Carol Ward Alan Wise 2 Hugh Marston 2, 4 Arran Turnbull 3 Simon P. Langdon Division of Pathology, Institute Genetics and Molecular Medicine, University Edinburgh, Western General Hospital, EH4 2XU, UK IOMET Pharma, Nine, Edinburgh BioQuarter, EH16 4UX, Breakthrough Breast Unit, Current Address: Eli Lilly Research Development, Windlesham, Surrey, GU20 6PH, Correspondence to: Langdon, e-mail: Simon.Langdon@ed.ac.uk Keywords: glycolysis, inhibitors, ovarian cancer,...
Novel therapeutic approaches are required to treat ovarian cancer and dependency on glycolysis may provide new targets for treatment. This study sought investigate the variation of expression molecular components (GLUT1, HKII, PKM2, LDHA) glycolytic pathway in cancers effectiveness targeting this cell lines with inhibitors. Expression GLUT1, LDHA were analysed by quantitative immunofluorescence a tissue microarray (TMA) analysis 380 associations clinicopathological features sought. The...
Radiotherapy plays an important role in the multimodal treatment of breast cancer. The response a tumour to radiation depends not only on its innate radiosensitivity but also repopulation by cells that have developed radioresistance. Development effective cancer treatments will require further molecular dissection processes contribute resistance.Radioresistant cell lines were established exposing MDA-MB-231, MCF-7 and ZR-751 parental increasing weekly doses radiation. development...
// Carol Ward 1 , James Meehan Peter Mullen 2 Claudiu Supuran 3 J. Michael Dixon 4 Jeremy S. Thomas 5 Jean-Yves Winum 6 Philippe Lambin 7 Ludwig Dubois Nanda-Kumar Pavathaneni 6, Edward Jarman Lorna Renshaw InHwa Um Charlene Kay David Harrison Ian H. Kunkler 8 Simon P. Langdon Division of Pathology, Institute Genetics and Molecular Medicine, University Edinburgh, United Kingdom School St Andrews, North Haugh, Università degli Studi di Firenze, Polo Scientifico, Laboratorio Chimica...
Tumour hypoxia is a driver of breast cancer progression associated with worse prognosis and more aggressive disease. The cellular response to mediated by the hypoxia-inducible transcription factors HIF-1 HIF-2, whose transcriptional activity canonically regulated through their oxygen-labile HIF-α subunits. These are constitutively degraded in presence oxygen; however, HIF-1α can be stabilised, even at high oxygen concentrations, activation HER receptor signalling. Despite this, there still...
Abstract Many inflammatory mediators retard granulocyte apoptosis. Most natural PGs studied herein (e.g., PGE2, PGA2, PGA1, PGF2α) either delayed apoptosis or had no effect, whereas PGD2 and its metabolite PGJ2 selectively induced eosinophil, but not neutrophil This novel proapoptotic effect does appear to be mediated via classical PG receptor ligation by elevation of intracellular cAMP Ca2+. Intriguingly, the sequential metabolites Δ12PGJ2 15-deoxy-Δ12, Δ14-PGJ2 (15dPGJ2) caspase-dependent...
Hypoxic cancer cells exhibit resistance to many therapies. This study compared the therapeutic effect of targeting pH regulatory proteins (CAIX, NHE1 and V-ATPase) that permit adapt hypoxic conditions, using both 2D 3D culture models. Drugs CAIX, V-ATPase exhibited anti-proliferative effects in MCF-7, MDA-MB-231 HBL-100 breast cell lines 2D. Protein gene expression analysis showed CAIX was most hypoxia-inducible protein 3 targets. However, differed between lines. difference hypoxia...
The natural polyphenol myricetin induces cell cycle arrest and apoptosis in preclinical cancer models. We hypothesised that myricetin-derived flavonoids with enhanced redox properties, improved uptake mitochondrial targeting might have increased potential as antitumour agents. studied the effect of a second-generation flavonoid analogue Oncamex panel seven breast lines, applying western blotting, gene expression analysis, fluorescence microscopy immunohistochemistry xenograft tissue to...
ABSTRACT GCs are highly effective in treating a wide range of inflammatory diseases but limited their ability to control neutrophilic lung inflammation conditions such as COPD. Neutrophil apoptosis, central feature resolution, is delayed response microenvironmental cues, hypoxia and cytokines, present at inflamed sites. delay neutrophil apoptosis vitro, this may therefore limit the inflammation. This study assesses effect have on hypoxia- cytokine-induced survival. Human neutrophils were...
Apoptosis renders eosinophils functionally effete and marks them for ‘silent’ removal from inflamed sites by macrophages. We show, the first time, that exposed to TNF-α rapidly lose their cytoplasmic levels of IκBα, inhibitory subunit NF-κB. Consequently, triggers NF-κB mobilization cytoplasm nucleus, as determined tracking p65 immunofluorescence Western blot analysis. Inhibition TNF-α-mediated IκBα degradation activation gliotoxin or proteasome inhibitor MG-132 un-masks caspase-dependent...