A5010761133- SARS-CoV-2 and COVID-19 Research
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- COVID-19 and Mental Health
- Vaccine Coverage and Hesitancy
- COVID-19 and healthcare impacts
- Streptococcal Infections and Treatments
- Garlic and Onion Studies
- Viral gastroenteritis research and epidemiology
- Immunotherapy and Immune Responses
- Parasites and Host Interactions
- Effects of Environmental Stressors on Livestock
- Pneumocystis jirovecii pneumonia detection and treatment
- Reproductive Physiology in Livestock
- Animal Nutrition and Physiology
- Ruminant Nutrition and Digestive Physiology
- Virology and Viral Diseases
- COVID-19 epidemiological studies
- Brain Metastases and Treatment
- Mollusks and Parasites Studies
University College London
2016-2025
The Francis Crick Institute
2020-2025
National Institute for Health Research
2021-2025
Örebro University Hospital
2025
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
2013-2024
University of Liverpool
2013-2024
University College London Hospitals NHS Foundation Trust
2009-2024
University College Hospital
2024
Imperial College London
2021-2024
Institute of Infection and Immunity
2018-2024
Abstract Coronavirus disease 2019 (COVID-19) antiviral response in a pan-tumor immune monitoring (CAPTURE) ( NCT03226886 ) is prospective cohort study of COVID-19 immunity patients with cancer. Here we evaluated 585 following administration two doses BNT162b2 or AZD1222 vaccines, administered 12 weeks apart. Seroconversion rates after were 85% and 59% solid hematological malignancies, respectively. A lower proportion had detectable titers neutralizing antibodies (NAbT) against severe acute...
Background. Therapy for human immunodeficiency virus (HIV)–associated cryptococcal meningitis in many centers Africa is fluconazole administered at a dosage of 400–800 mg per day. However, higher dosages have been used to treat patients without resulting serious toxicity. Pharmacokinetic and pharmacodynamic considerations suggest that might be associated with greater efficacy.
Post-COVID-19 complications require simultaneous characterisation and management to plan policy health system responses. We describe the 12-month experience of first UK dedicated post-COVID-19 clinical service include hospitalised non-hospitalised patients.
Abstract Post-COVID syndrome (PCS), or long COVID, is an increasingly recognized complication of acute SARS-CoV-2 infection, characterized by persistent fatigue, reduced exercise tolerance, chest pain, shortness breath, and cognitive slowing. Acute COVID-19 strongly linked with increased risk thrombosis, which a prothrombotic state quantified elevated von Willebrand factor (VWF) antigen (Ag)/ADAMTS13 ratio that associated severity infection. We investigated whether patients PCS also had...
Introduction Long COVID (LC), the persistent symptoms ≥12 weeks following acute COVID-19, presents major threats to individual and public health across countries, affecting over 1.5 million people in UK alone. Evidence-based interventions are urgently required an integrated care pathway approach pragmatic trials, which include investigations, treatments rehabilitation for LC, could provide scalable generalisable solutions at pace. Methods analysis This is a pragmatic, multi-centre,...
The emergence of successive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants concern (VOCs) during 2020 to 2022, each exhibiting increased epidemic growth relative earlier circulating variants, has created a need understand the drivers such growth. However, both pathogen biology and changing host characteristics—such as varying levels immunity—can combine influence replication transmission SARS-CoV-2 within between hosts. Disentangling role variant in individual-level...
Coronaviruses express their structural and accessory genes via a set of subgenomic RNAs, whose synthesis is directed by transcription regulatory sequences (TRSs) in the 5′ genomic leader upstream each body open reading frame. In SARS-CoV-2, TRS has consensus AAACGAAC; upon searching for emergence this motif global SARS-CoV-2 sequences, we find that it evolves frequently, especially 3′ end genome. We show well-supported examples Spike gene—within nsp16 coding region ORF1b—which expressed...
The emergence of a polybasic cleavage motif for the protease furin in SARS-CoV-2 spike has been established as major factor human viral transmission. region N-terminal to that is extensively mutated variants concern (VOCs). Besides furin, spikes from these appear rely on other proteases maturation, including TMPRSS2. Glycans near site have raised questions about proteolytic processing and consequences variant-borne mutations. Here, we identify sialic acid-containing O-linked glycans Thr678...
Patients with antibody deficiency respond poorly to coronavirus disease 2019 (COVID-19) vaccination and are at risk of severe or prolonged infection. They given long-term immunoglobulin replacement therapy (IRT) prepared from healthy donor plasma confer passive immunity against Following widespread COVID-19 alongside natural exposure, we hypothesized that preparations will now contain neutralizing acute respiratory syndrome 2 (SARS-CoV-2) spike antibodies, which protection may help treat chronic
Background SARS-CoV-2 variant Omicron rapidly evolved over 2022, causing three waves of infection due to sub-variants BA.1, BA.2 and BA.4/5. We sought characterise symptoms viral loads the course COVID-19 with these in otherwise-healthy, vaccinated, non-hospitalised adults, compared data infections preceding Delta concern (VOC). Methods In a prospective, observational cohort study, healthy vaccinated UK adults who reported positive polymerase chain reaction (PCR) or lateral flow test,...
Background. We documented bacterial meningitis trends among adults and children presenting to a large teaching hospital in Malawi during introduction of Haemophilus influenzae type b (Hib) vaccination the rollout antiretroviral therapy (ART).
Abstract Two mutations occurred in SARS-CoV-2 early during the COVID-19 pandemic that have come to define circulating virus lineages 1 : first a change spike protein (D614G) defines B.1 lineage and second, double substitution nucleocapsid (R203K, G204R) B.1.1 lineage, which has subsequently given rise three Variants of Concern: Alpha, Gamma Omicron. While latter appear unremarkable at level, there are dramatic implications nucleotide level: GGG→AAC generates new Transcription Regulatory...