Javier Costas
A5089597861- Genetic Associations and Epidemiology
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Child and Adolescent Psychosocial and Emotional Development
- Chromosomal and Genetic Variations
- Schizophrenia research and treatment
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- RNA Research and Splicing
- Genetic Mapping and Diversity in Plants and Animals
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Neurotransmitter Receptor Influence on Behavior
- Genomics and Chromatin Dynamics
- Bioinformatics and Genomic Networks
- CRISPR and Genetic Engineering
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Attachment and Relationship Dynamics
- Alcohol Consumption and Health Effects
- Mental Health Research Topics
- Tryptophan and brain disorders
Servicio Gallego de Salud
2016-2025
Instituto de Investigación Sanitaria de Santiago
2016-2025
Complexo Hospitalario Universitario A Coruña
2011-2025
Complejo Hospitalario Universitario de Santiago
2004-2025
Fundación Pública Galega de Medicina Xenómica
2005-2023
University of Bologna
2023
Hospital Clínico San Carlos
2023
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2023
Centro de Investigación Biomédica en Red de Salud Mental
2023
Universidade de Santiago de Compostela
2000-2015
We present a draft sequence of the genome Aedes aegypti, primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times size malaria Anopheles gambiae. Nearly 50% Ae. aegypti consists transposable elements. These contribute to factor 4 6 increase in average gene length sizes intergenic regions relative An. gambiae Drosophila melanogaster. Nonetheless, chromosomal synteny generally maintained among all three insects, although conservation...
Cannabis use is associated with increased risk of later psychotic disorder but whether it affects incidence the remains unclear. We aimed to identify patterns cannabis strongest effect on odds across Europe and explore differences in such contribute variations rates disorder.
Culex quinquefasciatus (the southern house mosquito) is an important mosquito vector of viruses such as West Nile virus and St. Louis encephalitis virus, well nematodes that cause lymphatic filariasis. C. one species within the pipiens complex can be found throughout tropical temperate climates world. The ability to take blood meals from birds, livestock, humans contributes its pathogens between species. Here, we describe genomic sequence quinquefasciatus: Its repertoire 18,883...
Abstract Schizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions encountered in medical practice. A recent landmark SCZ study of protein-coding regions genome identified causal role for ten genes concentration rare variant signals evolutionarily constrained 1 . This study—and other large-scale human genetics studies—was mainly composed individuals European (EUR) ancestry, generalizability findings non-EUR populations remains unclear. To address this gap, we...
Polymorphic variations in the serotonin transporter gene (5-HTT) moderate depressogenic effects of tryptophan depletion. After childbirth there is a sharp reduction brain availability, thus polymorphic 5-HTT may play similar role post-partum period.To study mood changes after delivery.One thousand, eight hundred and four depression-free Spanish women were studied post-partum. We evaluated depressive symptoms at 2-3 days, 8 weeks 32 used diagnostic interview to confirm major depression for...
Abstract A fundamental difficulty in human genetics research is the identification of spectrum genetic variants that contribute to susceptibility common/complex disorders. We tested here hypothesis functional may confer several related common analyzed five main psychiatric diagnostic categories (substance‐abuse, anxiety, eating, psychotic, and mood disorders) two different control groups, representing a total 3,214 samples, for 748 promoter non‐synonymous single nucleotide polymorphisms...
Brain-derived neurotrophic factor (BDNF) gene regulation has been linked to the pathophysiology of major depressive disorder (MDD). MDD patients show cognitive deficits, and altered BDNF a relevant role in neurocognitive functions. Our goal was explore association between genetic epigenetic variations with performance group healthy controls considering possible modulating factors. The sample included 134 subjects, 64 patients, 70 controls. Clinical data, childhood maltreatment, were assessed...
Abstract Common single-nucleotide polymorphisms (SNPs) account for a large proportion of the heritability obsessive-compulsive disorder (OCD). Co-ocurrence OCD and schizophrenia is commoner than expected based on their respective prevalences, complicating clinical management patients. This study addresses two main objectives: to identify particular genes associated with by SNP-based gene-based tests; test existence polygenic risk shared schizophrenia. The primary analysis was an exon-focused...
Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in independent case-control sample (N = 3,488). We then subset predisposing variation based on its effect LNL-ISO. find that genetic concordant effects both phenotypes shows significant SNP-based heritability enrichment, higher females, positive covariance mental disorders such as depression, anxiety,...
This study examines the intragenomic spread of human endogenous retrovirus family HERV-W from insertions present within draft sequence genome. Identification shared diagnostic differences and phylogenetic analyses revealed existence three main subfamilies. The average divergence between sequences for each subfamilies suggests that most elements were inserted genome during a short period evolutionary time. Each one consists two types insertions, expected proviral other resembling structure...
Abstract Background Variables such as the mother's personality, social support, coping strategies and stressful events have been described risk factors for postpartum depression. Structural Equation Modelling (SEM) analysis was used to examine whether neuroticism, perceived life events, are associated with depressive symptoms at 8th 32nd weeks. Methods A total of 1626 pregnant women participated in a longitudinal study. Different evaluations were performed 8 32 weeks after delivery. Several...
Abstract Schizophrenia (SCZ) is a complex disorder that typically arises in late adolescence or early adulthood. Age at onset (AAO) of SCZ associated with long-term outcomes the disease. We explored genetic architecture AAO genome-wide association study (GWAS), heritability, polygenic risk score (PRS), and copy number variant (CNV) analyses 4 740 subjects European ancestry. Although no significant locus was identified, SNP-based heritability estimated to be between 17 21%, indicating...