Anna Maaser
A5020615295- Genetic Associations and Epidemiology
- Bipolar Disorder and Treatment
- Genetics and Neurodevelopmental Disorders
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Autism Spectrum Disorder Research
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Rare Diseases
- Asthma and respiratory diseases
- Bioinformatics and Genomic Networks
- Nuclear Receptors and Signaling
- Cognitive Abilities and Testing
- Health, Environment, Cognitive Aging
- Mental Health Research Topics
- RNA regulation and disease
- Adolescent and Pediatric Healthcare
- Infections and bacterial resistance
- Inflammatory Bowel Disease
- Infectious Disease Case Reports and Treatments
- dental development and anomalies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Schizophrenia research and treatment
- Eosinophilic Esophagitis
- Child and Adolescent Psychosocial and Emotional Development
- Folate and B Vitamins Research
Mayo Clinic in Florida
2021
University of Bonn
2015-2020
University Hospital Bonn
2018-2020
Life & Brain (Germany)
2016-2019
Massachusetts General Hospital
2019
SUNY Upstate Medical University
2018
Southwest Jiaotong University
2018
Shanghai Jiao Tong University
2018
Wuxi People's Hospital
2018
Nanjing Medical University
2018
Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological remain largely unknown. A recent SCZ genome wide association study (GWAS) the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). present...
Abstract Bipolar disorder (BD) is a severe and highly heritable neuropsychiatric with lifetime prevalence of 1%. Molecular genetic studies have identified the first BD susceptibility genes. However, disease pathways remain largely unknown. Accumulating evidence suggests that microRNAs, class small noncoding RNAs, contribute to basic mechanisms underlying brain development plasticity, suggesting their possible involvement in pathogenesis several psychiatric disorders, including BD. In present...
Professional phagocytic cells such as macrophages are a central part of innate immune defence. They ingest microorganisms into membrane-bound compartments (phagosomes), which acidify and eventually fuse with lysosomes, exposing their contents to microbicidal environment. Gram-positive Rhodococcus equi can cause pneumonia in young foals immunocompromised humans. The possession virulence plasmid allows them subvert host defence mechanisms multiply macrophages. Here, we show that the...
Objectives Social anxiety disorder (SAD) is a common and heritable psychiatric disorder. However, genetic studies in SAD are rare only few candidate genes have been implicated so far. In the present study, we investigated whether single-nucleotide polymorphisms (SNPs) associated with other disorders also contribute toward development of followed up variants on phenotypic level. Patients methods We genotyped total 24 SNPs German sample 321 patients 804 controls. carried out single-marker...
Nonsyndromic cleft palate only (nsCPO) is a facial malformation that has livebirth prevalence of 1 in 2,500. Research suggests the etiology nsCPO multifactorial, with clear genetic component. To date, genome-wide association studies have identified conclusive common variant for nsCPO, is, missense gene grainyhead-like-3 ( GRHL3). Thus, underlying causes remain largely unknown. The present study aimed at identifying rare variants might contribute to risk, via whole-exome sequencing (WES),...
Abstract Advanced paternal age (APA) is a risk factor for several neurodevelopmental disorders, including autism and schizophrenia. The potential mechanisms conferring this are poorly understood. Here, we show that the personality traits schizotypy neuroticism correlated with in healthy subjects ( N = 677). Paternal was further positively associated gray matter volume (VBM, 342) right prefrontal medial temporal cortex. integrity of fiber tracts (DTI, 222) connecting these two areas age....
Bipolar disorder (BD) is a major psychiatric illness affecting around 1% of the global population. BD characterized by recurrent manic and depressive episodes, has an estimated heritability 70%. Research identified first susceptibility genes. However, underlying pathways regulatory networks remain largely unknown. suggests that cumulative impact common alleles with small effects explains only 25-38% phenotypic variance for BD. A plausible hypothesis therefore rare, high penetrance variants...
ABSTRACT Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behavior. Genome-wide association studies (GWAS) have identified several risk loci that together account for small portion the heritability. To identify additional loci, we performed two-stage meta-analysis >9 million genetic variants in 9,784 bipolar patients 30,471 controls, largest GWAS BD to date. In this study, increase power used ~2,000 lithium-treated cases with...
VEGAS (versatile gene-based association study) is a popular methodological framework to perform tests based on summary statistics from single-variant analyses. The approach incorporates linkage disequilibrium information reference panels account for the correlation of test statistics. can utilize three different types tests. In 2015, improved VEGAS2, using more detailed panels, was published. Both versions provide user-friendly web- and offline-based tools analysis. However, implementation...
Abstract VEGAS (versatile gene-based association study) is a popular methodological framework to perform tests based on summary statistics from single-variant analyses. The approach incorporates linkage disequilibrium information reference panels account for the correlation of test statistics. can utilize three different types tests. In 2015, improved VEGAS2, using more detailed panels, was published. Both versions provide user-friendly web- and offline-based tools analysis. However,...
Guangji Hospital of Soochow University in Suzhou, China on