A5100753591- CAR-T cell therapy research
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Nanowire Synthesis and Applications
- Advanced MRI Techniques and Applications
- Protein Degradation and Inhibitors
- Molecular Biology Techniques and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Transcranial Magnetic Stimulation Studies
- Acute Lymphoblastic Leukemia research
- Circular RNAs in diseases
- Nanoparticles: synthesis and applications
- Chronic Myeloid Leukemia Treatments
- Genetics and Neurodevelopmental Disorders
- Acute Kidney Injury Research
- Parvovirus B19 Infection Studies
- MicroRNA in disease regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Neuroscience and Neuropharmacology Research
- Advancements in Semiconductor Devices and Circuit Design
- Cardiac Ischemia and Reperfusion
- Extracellular vesicles in disease
Sun Yat-sen University
2025
Tsinghua University
2018-2022
Center for Life Sciences
2021-2022
Chongqing Dazu District People's Hospital
2020
Zhejiang University
2015
Chimeric antigen receptor T (CAR-T) cell therapies have demonstrated high response rate and durable disease control for the treatment of B malignancies. However, in case solid tumors, CAR-T cells shown limited efficacy, which is partially attributed to intrinsic defects CAR signaling. Here, we construct a double-chain chimeric receptor, termed as synthetic (TCR) (STAR), incorporates antigen-recognition domain antibody constant regions TCR that engage endogenous CD3 signaling machinery. Under...
Abstract The rapid success of RNA vaccines in preventing SARS-CoV-2 has sparked interest their use for cancer immunotherapy. Although many cancers originate mucosal tissues, current are mainly administered non-mucosally. Here, we developed a non-invasive intranasal vaccine utilizing circular encapsulated lipid nanoparticles to induce localized immune responses. This strategy elicited potent anti-tumor T cell responses preclinical lung models while mitigating the systemic adverse effects...
Abstract We developed a T‐cell‐receptor (TCR) complex‐based chimeric antigen receptor (CAR) named S ynthetic T CR and A ntigen R eceptor (STAR). Here, we report pre‐clinical phase I clinical trial data (NCT03953599) of this T‐cell therapy for refractory relapsed (R/R) B‐cell acute lymphoblastic leukemia (B‐ALL) patients. STAR consists two protein modules each containing an antibody light or heavy chain variable region TCR α β constant fused to the co‐stimulatory domain OX40. T‐cells were...
This study explored the mechanism of NEAT1 in sepsis-induced AKI rats. Cecal ligation punctures (CLP)-induced rats were injected with siRNA-NEAT1 lentivirus. Kidney histopathology and apoptosis evaluated via hematoxylin-eosin TUNEL staining, respectively. ELISA determined levels Blood urea nitrogen (BUN), serum creatinine (SCr), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), TNF-α, Interleukin (IL)-1β, IL-6. Colorimetry measured malondialdehyde (MDA),...
Minifilament (MF) eruption producing small jets and micro-flares is regarded as an important source for coronal heating the solar wind transients through studies mostly based on observations in extreme ultraviolet (EUV) X-ray wavelengths. In this study, we focus chromospheric plasma diagnostics of a tiny minifilament quiet Sun located at [71'', 450''] 2021--08--07 19:11 UT observed part ninth encounter PSP campaign. Main data obtained are high cadence, resolution spectroscopy from Fast...
Motivation: Ultra-high field MRI is popular in brain imaging research. However, high-res of carotid vessels and walls not possible due to the lack a array. Goal(s): High-resolution neck position at ultra-high fieldsApproach: In this study, array with two wireless resonators insert was developed 5T. Results: SNR significantly improved using novel coil comparison only Impact: An 8-channel designed for 5T magnetic resonance imaging. Water model provides sufficient signal-to-noise ratio...