A5101609899- Acne and Rosacea Treatments and Effects
- melanin and skin pigmentation
- Pharmacological Effects of Natural Compounds
- Herpesvirus Infections and Treatments
- Skin Protection and Aging
- Dermatologic Treatments and Research
- Dermatology and Skin Diseases
- Vitamin C and Antioxidants Research
- Systemic Lupus Erythematosus Research
- Natural product bioactivities and synthesis
- Histone Deacetylase Inhibitors Research
- Bee Products Chemical Analysis
- Atherosclerosis and Cardiovascular Diseases
- Biochemical Analysis and Sensing Techniques
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Single-cell and spatial transcriptomics
- Neonatal skin health care
- Dye analysis and toxicity
- Genetics, Aging, and Longevity in Model Organisms
- Protein Degradation and Inhibitors
- Bioactive Compounds and Antitumor Agents
- Photodynamic Therapy Research Studies
- Cytokine Signaling Pathways and Interactions
- Nonmelanoma Skin Cancer Studies
Central South University
2016-2025
Xiangya Hospital Central South University
2016-2025
The First Hospital of Changsha
2023
RELX Group (Netherlands)
2022
Second Affiliated Hospital of Xinjiang Medical University
2021
Xinjiang Medical University
2021
Karolinska University Hospital
2012
Karolinska Institutet
2012
Rosacea is an inflammatory skin disorder characterized by the release of mediators from keratinocytes, which are thought to play a crucial role in its pathogenesis. Despite incidence approximately 5.5%, rosacea associated with poor quality life. However, as pathogenesis remains enigmatic, treatment options limited. To investigate and explore new therapeutic strategies. Transcriptome data patients combined immunohistochemical staining were used activation STAT3 rosacea. The was subsequently...
Rosacea is a chronic inflammatory skin disorder whose pathogenesis unclear. Here, several lines of evidence were provided to demonstrate that mTORC1 signaling hyperactivated in the skin, especially epidermis, both rosacea patients and mouse model rosacea-like inflammation. Both deletion epithelium inhibition by its specific inhibitors can block development inflammation LL37-induced model. Conversely, hyperactivation aggravated features. Mechanistically, regulates cathelicidin through...
Rosacea is a facial chronic inflammatory skin disease with dysfunction of immune and vascular system. Artemisinin (ART), an anti-malaria drug, was reported to have several effects including anti-inflammation anti-angiogenesis activities. However, the role ART on rosacea remains unclear.To investigate molecular mechanism rosacea.In rosacea-like mouse model, phenotype lesions evaluated by redness score, biomarkers were analyzed qPCR, infiltration cells assessed IHC analysis immunofluorescence....
Hair follicle stem cells (HFSCs) are maintained in a quiescent state until activated to grow, but the mechanisms that reactivate HFSC reservoir unclear. Here, we find loss of Sirt7 mice impedes hair life-cycle transition from telogen anagen phase, resulting delay growth. Conversely, overexpression during phase facilitated HSFC entry and accelerated Mechanistically, is upregulated HFSCs telogen-to-anagen transition, HFSC-specific knockout (Sirt7f/f ;K15-Cre) exhibit similar growth delay. At...
Abstract Rosacea is a chronic inflammatory skin disorder whose pathophysiological mechanism remains largely unknown. Although recent studies have revealed the hypersensitivity of towards chemical, thermal and biological stimuli, there no direct molecular evidence suggesting barrier impaired in rosacea. In this study, we demonstrated that mRNA levels most claudins ( CLDN ), main components tight junctions determining major paracellular pathway between epithelial cells, were lowered lesional...
Rosacea is significantly associated with dementia, particularly Alzheimer's disease (AD). However, the common underlying molecular mechanism connecting these two diseases remains limited. This study aimed to reveal regulatory networks and identify potential therapeutic drugs for rosacea AD. There were 747 overlapped DEGs (ol-DEGs) that detected in AD rosacea, enriched inflammation-, metabolism-, apoptosis-related pathways. Using TF network analysis, 37 TFs target genes identified as hub...
Abstract Rosacea is a common chronic skin disorder of unknown etiology. While population prevalence rates range 0.2–22% in Europe and North America, China currently undetermined. We conducted large population‐based case–control study to determine the present epidemiological status rosacea China, involving 10 095 participants aged 0–100 years (mean age, 35.5 ± 19.1; 50.5% female). A census among 15 communities Changsha south central was with examination by board‐certified dermatologists....
Aquaporin 3 (AQP3) is a protein implicated in skin hydration. AQP3 null mice have relatively dry skin, reduced elasticity, and delayed recovery of barrier function after removal the stratum corneum which also present old people. A feature aging change both water content skin. We investigated expression aquaporin non sun-exposed human normal keratinocytes fibroblasts from different age groups to further understand relationship between intrinsic aging.We aquaporin3 epidermal (NHEK) fibroblast...
Background The epidemiologic profiles of chronic urticaria (CU) vary considerably among regions, and few such data are available from China. Methods We performed a multicenter open questionnaire investigation about the clinical laboratory features CU, defined as recurrent wheals with/without angioedema lasting for ≥6 weeks, 3027 patients. Results Female preponderance was observed (female/male ratio, 1.46 : 1). mean age at diagnosis 34.7 ± 13.8 years, disease duration 18.5 46.1 months (range,...
Rosacea is a chronic inflammatory cutaneous disease which mainly affects central face, leading to cosmetic disfigurement and compromised social psychology in billions of rosacea patients. Though the exact etiology remains elusive, accumulating evidence has highlighted dysfunction innate immunity inflammation pathogenesis. Disintegrin Metalloprotease ADAM-like Decysin-1 (ADAMDEC1) an orphan metalloprotease believed be closely related inflammation. Here for first time, we reported that...
Rosacea is a chronic inflammatory skin disorder of uncertain etiology. Evidence suggests the underlying pathogenesis modulated by abnormal and vascular responses. Thalidomide synthetic derivative acid with anti-inflammatory anti-angiogenic properties. However, its effects on rosacea remain unknown. To investigate thalidomide lesional alterations molecular mechanisms in rosacea. Mice were intradermally injected LL37 to induce rosacea-like features intraperitoneally administered thalidomide....
Rosacea is a common chronic inflammatory condition that mainly affects the central face. However, molecular background of normal face and transcriptional profiling immune cell composition rosacea lesions remain largely unknown. Here, we performed whole-skin epidermal RNA-seq facial skin from healthy individuals, matched patients. From RNA-seq, site-specific gene signatures for were enriched in epithelial differentiation, with upregulation activator protein-1 (AP1) transcription factor (TF)....
Abstract Although patients with rosacea often consult dermatologists for dietary factors that might be related to their skin disorders, few studies have been conducted research the relationship between and factors. The purpose of this study was evaluate potential diet among large Chinese population rosacea, which would provide guidelines rosacea. A multicenter case–control conducted. feeding frequency 2 years before occurrence collected by standardized questionnaires. Multiple logistic...
Objective: Rosacea is a chronic inflammatory skin disease with high morbidity. Previous studies have described the contribution of barrier dysfunction (SBD) in progression rosacea, but specific mechanism remains unclear. In this study, we aim to investigate key genes that may involve SBD-mediated rosacea aggravation. Methods: evaluated SBD patterns based on expression 23 barrier-related (SBRGs) using consensus clustering analysis, and revealed immune cells infiltration GSE65914 dataset. The...
To evaluate the clinical characteristics and epidermal barrier function of papulopustular rosacea by comparing with acne vulgaris.Four hundred sixty-three patients four twelve vulgaris were selected for study in Xiangya Hospital Central South University from March 2015 to May 2016. They analyzed major facial lesions, self-conscious symptoms function.Erythema, burning, dryness itching presented significantly higher than that (P<0.001). The scores erythema, those water content stratum cornuem...
Rosacea is a common chronic facial disorder that affects patients' health-related quality of life; the only questionnaire designed specifically for rosacea Rosacea-specific Quality-of-Life instrument (RosQol). However, has not been validated among Chinese patients. This study aimed to validate version RosQol. First, we translated into Chinese. Then, patients completed RosQol and Dermatology Life Quality Index, indicating disease's impact on their lives. We also collected demographic clinical...