A5018392486- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver physiology and pathology
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Cancer Genomics and Diagnostics
- Hepatitis B Virus Studies
- Alcohol Consumption and Health Effects
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Fungal and yeast genetics research
- Gallbladder and Bile Duct Disorders
- Cytokine Signaling Pathways and Interactions
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Bioinformatics and Genomic Networks
- Aortic aneurysm repair treatments
- Ubiquitin and proteasome pathways
- Hepatitis C virus research
- Cancer Cells and Metastasis
- Viral-associated cancers and disorders
University of Florida
2017-2025
Florida College
2017-2025
University of Pittsburgh
2024
University of Florida Health
2018-2024
University of Florida Health Science Center
2017-2024
UF Health Cancer Center
2024
University of Toledo
2024
National Center for Advancing Translational Sciences
2021-2023
National Institutes of Health
2023
Washington University in St. Louis
2023
In Brief Objective: To analyze incidence, outcomes, and utilization of health care resources in liver transplantation (LT) for nonalcoholic steatohepatitis (NASH). Summary Background Data: With the epidemic obesity metabolic syndrome nearly 33% US population, NASH is projected to become leading indication LT next several years. Data on predictors outcome after limited. Methods: We conducted an analysis from our prospective database 144 adult patients who underwent between December 1993...
How scaffold proteins control information flow in signaling pathways is poorly understood: Do they simply tether components, or do precisely orient and activate them? We found that the yeast mitogen-activated protein (MAP) kinase Ste5 tolerant to major stereochemical perturbations; heterologous interactions could functionally replace native recruitment interactions, indicating simple tethering largely sufficient for scaffold-mediated signaling. Moreover, by engineering a tethers unique set,...
To analyze a 28-year single-center experience with orthotopic liver transplantation (OLT) for patients irreversible failure.The implementation of the model end-stage disease (MELD) in 2002 represented fundamental shift donor allocation to recipients highest acuity, raising concerns about posttransplant outcome and morbidity.Outcomes factors affecting survival were analyzed 5347 consecutive OLTs performed 3752 adults 822 children between 1984 2012, including comparisons recipient...
Early allograft dysfunction (EAD) following a liver transplant (LT) unequivocally portends adverse graft and patient outcomes, but widely accepted classification or grading system is lacking.To develop model for individualized risk estimation of failure after LT then compare the model's prognostic performance with existing binary EAD definition (bilirubin level ≥10 mg/dL on postoperative day 7, international normalized ratio ≥1.6 aspartate aminotransferase alanine >2000 U/L within first 7...
Posttransplant immunosuppressive drugs such as tacrolimus have narrow therapeutic ranges. Inter- and intraindividual variability in dosing requirements conventionally use physician-guided titrated drug administration, which results frequent deviations from the target trough ranges, particularly during critical postoperative phase. There is a clear need for personalized management of posttransplant regimens to prevent adverse events allow patient be discharged sooner. We developed parabolic...
In Brief Objectives: To evaluate the rate, effect, and predictive factors of a complete pathologic response (cPR) in patients with hepatocellular carcinoma (HCC) undergoing locoregional therapy (LRT) before liver transplantation (LT). Background: Eligible HCC receive equal model for end-stage disease prioritization, despite variable risks tumor progression, waitlist dropout, posttransplant recurrence. Pretransplant LRT mitigates these by inducing necrosis. Methods: Comparisons were made...
An accurate clinical assessment of hepatic steatosis before transplantation is critical for successful outcomes after liver transplantation, especially if a pathologist not available at the time procurement. This prospective study investigated surgeon's accuracy in predicting and organ quality 201 adult donor livers. A by blinded expert served as reference gold standard. The estimate correlated more strongly with large-droplet macrovesicular [ld-MaS; nonparametric Spearman correlation...
The role of insulin resistance in hepatic fibrosis Metabolic dysfunction-Associated SteatoHepatitis (MASH) remains unclear. Carcinoembryonic Antigen-related Cell Adhesion Molecule1 protein (CEACAM1) promotes clearance to maintain sensitivity and repress de novo lipogenesis, as bolstered by the development steatohepatitis AlbuminCre + Cc1
Serum α-fetoprotein (AFP) is a biomarker for hepatocellular carcinomas (HCCs) associated with more aggressive tumor phenotype and inferior outcomes after liver transplant (LT). Data on the patients HCCs that do not produce AFP are limited.To compare characteristics among LT recipients radiographically apparent HCC lesions AFP-producing tumors or (hereafter referred to as non-AFP-producing tumors), identify factors influencing recurrence in tumors.Retrospective analysis at university center...
Objective: We sought to evaluate outcomes and predictors of renal allograft futility (RAF—patient death or need for replacement therapy at 3 months) after simultaneous liver-kidney transplantation (SLKT). Background: Model End-Stage Liver Disease (MELD) prioritization liver recipients with dysfunction has significantly increased utilization SLKT. Data on SLKT in the highest MELD are scarce, as accurate recovery native kidney function. Without well-established listing guidelines, potentially...
Liver ischemia–reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and key obstacle to expanding the donor pool in orthotopic liver transplantation (OLT). Although autophagy is essential for resistance against hepatic IRI, its significance clinical OLT remains unknown. Despite recent data identifying heme oxygenase-1 (HO-1) as putative inducer, role interactions with sirtuin-1 (SIRT1), regulator, have not been studied. We aimed examine HO-1–mediated induction...
BACKGROUND. Orthotopic liver transplant (OLT) is the primary therapy for end-stage disease and acute failure. However, ischemia/reperfusion injury (IRI) can severely compromise allograft survival. To understand evolution of immune responses underlying OLT-IRI, we evaluated longitudinal cytokine expression profiles from adult OLT recipients before through 1 month after transplant.
Recent technological advances have enabled real-time near-infrared fluorescence cholangiography (NIRFC) with indocyanine green (ICG). Whereas several studies shown its feasibility, dosing and timing for practical use not been optimized. We undertook a prospective study systematic variation of from injection ICG to visualization. Adult patients undergoing laparoscopic biliary hepatic operations were enrolled. Intravenous (0.02-0.25 mg/kg) was administered at times ranging 10 180 minutes prior...