A5073673612- Reproductive System and Pregnancy
- Reproductive Physiology in Livestock
- Reproductive Biology and Fertility
- Immune Response and Inflammation
- Virus-based gene therapy research
- Sperm and Testicular Function
- Pregnancy and preeclampsia studies
- Cancer-related molecular mechanisms research
- Birth, Development, and Health
- Pregnancy and Medication Impact
- Estrogen and related hormone effects
- Neural and Behavioral Psychology Studies
- Preterm Birth and Chorioamnionitis
- Fatty Acid Research and Health
- Aquaculture disease management and microbiota
- Neonatal Respiratory Health Research
- Neurotransmitter Receptor Influence on Behavior
- IL-33, ST2, and ILC Pathways
- Assisted Reproductive Technology and Twin Pregnancy
- Advanced Fiber Laser Technologies
- T-cell and Retrovirus Studies
- Ovarian function and disorders
- Fibroblast Growth Factor Research
- Genetics, Aging, and Longevity in Model Organisms
- Complement system in diseases
Hebei University of Engineering
2016-2025
Hubei University of Science and Technology
2025
First Affiliated Hospital of Soochow University
2018-2025
Soochow University
2009-2025
Xinjiang Medical University
2025
Chengdu Medical College
2025
North Sichuan Medical University
2025
Union Hospital
2024
Huazhong University of Science and Technology
2024
Guangdong Pharmaceutical University
2022-2024
DNA methylation is an important biological form of epigenetic modification, playing key roles in plant development and environmental responses. In this study, we examined single-base resolution methylomes Populus under control drought stress conditions using high-throughput bisulfite sequencing for the first time. Our data showed levels methylated cytosines, upstream 2kp, downstream 2kb, repeatitive sequences significantly increased after treatment Populus. Interestingly, 100 bp...
Leiomyomatosis peritonealis disseminata (LPD) is a rare and specific type of leiomyomatosis that often misdiagnosed as malignant tumor with peritoneal metastasis, accurate diagnosis critical to treatment planning. The purpose this study investigate the radiological features LPD, analyze, summarize its differential clinical improve understanding disease. A retrospective analysis was conducted on from 10 patients pathologically confirmed LPD between 2012 2024. computed tomography (CT) magnetic...
Osteocalcin (OC), a major noncollagenous bone matrix protein, is expressed prevalently in prostate cancer epithelial cells, adjacent fibromuscular stromal and osteoblasts locally recurrent metastasis [Matsubara, S., Wada, Y., Gardner, T.A., Egawa, M., Park, M.S., Hsieh, C.L., Zhau, H.E., Kao, C., Kamidono, Gillenwater, J.Y., Chung, L.W. (2001). Cancer Res. 61, 6012-6019]. We constructed an adenovirus vector carrying osteocalcin promoter-driven herpes simplex virus thymidine kinase...
The aims of the study are to explore effect ursolic acid (UA) on growth gastric cancer cell line BGC‐803 and hepatocellular H22 xenograft understand mechanism. UA inhibits cells in vitro dose‐dependent time‐dependent manner. Treated with vivo, tumor can be arrested G0/G1 stage. apoptotic rate was significantly increased treated both vivo. DNA fragmentation found exposed UA. activated caspase‐3, ‐8, ‐9 down regulated expression Bcl‐2 cells. caspase‐3 ‐8 elevated from 18 F‐FLT PET‐CT imaging...
Executive function (EF), its importance for scholastic achievement and the question of whether or not EF is malleable, have become a topic intense interest. Education schooling often seen as effective approaches to enhance due specific school-related requirements compared kindergarten pre-school. However, no study date has investigated targeted training focusing on those domains might be comparable with regular in improving fluid intelligence (Gf). The aim present was replicate extend...
Background Epidermal growth factor (EGF) signaling is implicated in the invasion and metastasis of hepatoma cells. However, pathways for EGF-induced motility cells remain undefined. Methodology/Principal Findings We found that EGF dose-dependently stimulated migration human HepG2, with maximal effect at 10 ng/mL. Additionally, increased Arf6 activity, ectopic expression T27N, a dominant negative mutant, largely abolish cell migration. Blocking GEP100 siRNA or GEP100-△PH, pleckstrin homology...
The spleen is a unique lymphoid organ that plays key role in immune regulation. Interferon-tau induces upregulation of interferon-stimulated gene 15-kDa protein (ISG15) the uterus during early pregnancy sheep. Prostaglandins (PGs) have important effects both activation and inhibition response through an autocrine paracrine manner. In this study, splenic samples were obtained at Day 16 estrous cycle, Days 13, 16, 25 from ewes, expression ISG15 PG synthases, including cyclooxygenase 1 (COX-1),...
Melatonin treatment can improve quality and in vitro development of porcine oocytes, but the mechanism improving developmental competence is not fully understood. In this study, cumulus-oocyte complexes were cultured TCM199 medium with non-treated (control), 10-5 M luzindole (melatonin receptor antagonist), melatonin, melatonin + during maturation, parthenogenetically activated (PA) embryos treated nothing or melatonin. Cumulus oophorus expansion, oocyte survival rate, first polar body...
Ammonium transporters (AMTs) are plasma membrane proteins mediating ammonium uptake and transport. As such, AMTs play vital roles in acquisition mobilization, plant growth development, stress pathogen defense responses. Identification of favorable AMT genotypes is a prime target for crop improvement. However, to date, systematic identification expression analysis gene family members has not yet been reported rapeseed (Brassica napus L.). In this study, 20 genes were identified comprehensive...
Suicide and major depressive disorders (MDD) are strongly associated, genetic factors responsible for at least part of the variability in suicide risk. We investigated whether variation tryptophan hydroxylase-2 (TPH2) gene rs7305115 SNP may predispose to attempts MDD. genotyped TPH2 215 MDD patients with matched without suicide. Differences behavioral personality traits according genotypic were by logistic regression analysis. There no significant differences between controls (AG GG)...
The genetic basis underlying cervical tumorigenesis and progression are largely unknown. Phosphatase tensin homologue (PTEN) is a tumor suppressor gene, changes of PTEN occurs in various types cancer suggesting that the inactivation may play an important role pathogenesis variety human malignancies. In present study, 102 specimens were examined for expression gene promoter methylation using methylation-specific-polymerase chain reaction immunohistochemistry. mutation was also assessed PCR...
MicroRNAs (miRNAs) play important roles in regulation of many biological processes eukaryotes, including pathogen infection and host interactions. Flavobacterium columnare (FC) can cause great economic loss common carp (Cyprinus carpio) which is one the most cultured fish world. However, miRNAs response to FC has not been characterized. To identify specific involved infected with FC, we performed microRNA sequencing using livers without FC. A total 698 were identified, 142 identified...
Lymph nodes are distributed all over the body and part of lymphatic system. The interferon‐stimulated gene 15 kDa protein (ISG15) prostaglandins (PGs) involved in establishment pregnancy expressed uterus during early sheep. In this study, ovine lymph were obtained on Day 16 estrous cycle, Days 13, 16, 25 pregnancy, expression ISG15 PG synthases, including cyclooxygenase 1 (COX‐1), COX‐2, prostaglandin E (PGE) synthase (PTGES), a PGF (aldo‐keto reductase family 1, member B1, AKR1B1) detected...
Summary As a pineal gland hormone, melatonin acts through its receptors to modulate the immune system. The system is composed of primary and secondary organs, organs are adapted presence fetal alloantigen during pregnancy. However, it unclear whether affects maternal early pregnancy in sheep. In this study, ovine thymus, lymph node, spleen liver were sampled at day 16 oestrous cycle, days 13, 25 expression receptor 1A (MT1), 1B (MT2) cluster differentiation 4 (CD4) was detected by...
Contents Interferon‐tau (IFN‐τ) is a secreted conceptus protein which plays critical role in the establishment of ruminant pregnancy by its antiluteolytic and antiviral effects. In present study, we hypothesized that IFN‐τ expression was temporally spatially regulated different pre‐implantation embryos levels were among bovine derived from parthenogenetic activation (PA), vitro fertilization (IVF) somatic cell nuclear transfer (SCNT). By using situ hybridization with Digoxingenin...
Tryptophan hydroxylase‑2 (TPH2) contributes to alterations in the function of neuronal serotonin (5‑HT), which are associated with various psychopathologies, including major depressive disorder (MDD) or suicidal behavior. The methylation a single CpG site promoter region TPH2 affects gene expression. Suicide and MDD strongly genetic factors at least partially responsible for variability suicide risk. aim present study was investigate whether variations peripheral blood samples may predispose...