A5059009818- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Neural dynamics and brain function
- Infection Control and Ventilation
- Neurobiology and Insect Physiology Research
- Particle Dynamics in Fluid Flows
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Aerosol Filtration and Electrostatic Precipitation
- Neuroscience and Neural Engineering
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Neuroendocrine regulation and behavior
- Pain Mechanisms and Treatments
- Nicotinic Acetylcholine Receptors Study
- Intensive Care Unit Cognitive Disorders
- Medical Device Sterilization and Disinfection
- Transcranial Magnetic Stimulation Studies
- Plant Surface Properties and Treatments
- Cyclone Separators and Fluid Dynamics
- Pharmacological Receptor Mechanisms and Effects
- Dermatology and Skin Diseases
- Adenosine and Purinergic Signaling
- Neurological disorders and treatments
Dalian University of Technology
2022-2024
Chinese Institute for Brain Research
2019-2023
Westlake University
2022-2023
ShanghaiTech University
2023
Peking University
2021
Chinese Academy of Sciences
2012-2019
University of Chinese Academy of Sciences
2013-2019
Institute of Biophysics
2012-2019
Associative learning and memory are essential to logical thinking cognition. How the neurons recruited as associative cells encode multiple input signals for their associated storage distinguishable retrieval remains unclear. We studied this issue in barrel cortex by vivo two-photon calcium imaging, electrophysiology neural tracing our mouse model that simultaneous whisker olfaction stimulations led odorant-induced motion. After cross-modal reflex arose, piriform cortices connected. More...
BackgroundDespite the fundamental clinical significance of general anaesthesia, cortical mechanism underlying anaesthetic-induced loss consciousness (aLOC) remains elusive.MethodsHere, we measured dynamics two major neurotransmitters, gamma-aminobutyric acid (GABA) and glutamate, through in vivo two-photon imaging genetically encoded neurotransmitter sensors a cell type-specific manner primary visual (V1) cortex.FindingsWe found decrease GABA transmission during aLOC. However, glutamate...
Abstract Loss of a sensory input causes the hypersensitivity in other modalities. In addition to cross-modal plasticity, cortices without receiving inputs undergo plastic changes. It is not clear how different types neurons and synapses cortex coordinately change after deficits order prevent loss their functions be used for We studied this subject barrel from whiskers-trimmed mice vs. controls. After whisker trimming week, intrinsic properties pyramidal transmission excitatory were...
Somatosensory signals and operative skills learned by unilateral limbs can be retrieved bilaterally. In terms of cellular mechanism underlying this learning toward bilateral memory, we hypothesized that associative memory cells in cortices synapse innervations between them were produced. the examination hypothesis, have observed paired whisker odor stimulations led to odorant-induced motions sides, which attenuated inhibiting activity barrel cortices. mice showed cross-modal responses,...
Neural plasticity is associated with memory formation. The coordinated refinement and interaction between cortical glutamatergic GABAergic neurons remain elusive in associative memory, which we examine a mouse model of learning. In the mice that show odorant-induced whisker motion after pairing odor stimulations, barrel are recruited to encode newly learnt signal alongside innate signal. These functionally upregulated, refined homeostatic manner. mutual innervations these upregulated....
Neural plasticity occurs in learning and memory. Coordinated at glutamatergic GABAergic neurons during memory formation remains elusive, which we investigate a mouse model of associative by cellular imaging electrophysiology. Paired odor whisker stimulations lead to whisker-induced olfaction response. In mice that express this cross-modal memory, the piriform cortex are recruited encode newly acquired signal alongside innate signal, their response patterns these associated signals different....
Cross-modal plasticity is characterized as the hypersensitivity of remaining modalities after a sensory function lost in rodents, which ensures their awareness to environmental changes. Cellular and molecular mechanisms underlying cross-modal remain unclear. We aim study role different types neurons plasticity.
Sustained ramping of dopaminergic activation helps individuals resist impulsivity and wait for a later but larger reward.
Squat toilets are widely used in developing countries due to local customs and low costs. The flushing of a squat toilet can entrain strong airflow produce aerosols. This investigation constructed lavatory mock-up with toilet. flushing-induced was both visualized quantitatively measured by particle image velocimetry. maximum height the impacted identified an ultrasonic anemometer. For inference emission rate, bowl covered enclosed box for concentration measurement. risks from skin contact...
Deep brain stimulation (DBS) is a clinical intervention for the treatment of movement disorders. It has also been applied to psychiatric disorders such as depression, anorexia nervosa, obsessive-compulsive disorder, and schizophrenia. Psychiatric including schizophrenia, bipolar major depression can lead psychosis, which cause patients lose touch with reality. The ventral tegmental area (VTA), located near midline midbrain, an important region involved in psychosis. However, application...
Morphine is commonly used to relieve moderate severe pain, but repeated doses cause opioid tolerance. Here, we ATP sensor and fiber photometry detect prefrontal level. It showed that level decreased after morphine injection the event amplitude tended decrease with continuous exposure. had little effect on due its Therefore, hypothesized analgesic of might be related in medial cortex (mPFC). Moreover, local infusion partially antagonized analgesia. Then found inhibiting P2X7R mPFC mimicked In...
Abstract Postoperative delirium (POD) is a complicated and harmful clinical syndrome. Traditional behaviour analysis mostly focuses on static parameters. However, animal bottom-up hierarchical organizational structure composed of time-varying posture dynamics. Spontaneous task-driven behaviours are used to conduct comprehensive profiling behavioural data various aspects model animals. A machine-learning based method assess the effect dexmedetomidine. Fourteen statistically different...
Abstract Balancing instant gratification versus delayed, but better is important for optimizing survival and reproductive success. Although psychologists neuroscientists have long attempted to study delayed through human psychological brain activity monitoring, animal research, little known about its neural basis. We successfully trained mice perform a waiting-and-water-reward task used these animals in physiological recording optical manipulation of neuronal during the explore Our results...
The high-speed jet discharged by hand dryers with brushed motors may release hazardous particles. In this study, the particles released from dryer were trapped using high-efficiency particulate air filters for chemical composition analysis in a small test room. A manikin was placed to mimic user standing front of dryer. Number and mass concentrations measured estimate particle emission rates inhalation exposure. rate reached 2.64*E6 particles/s when starting found contain copper element,...