A5101926228- MicroRNA in disease regulation
- Gut microbiota and health
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- IL-33, ST2, and ILC Pathways
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Bone Metabolism and Diseases
- Marine Sponges and Natural Products
- Cancer-related gene regulation
- Bone Tumor Diagnosis and Treatments
- Mycobacterium research and diagnosis
- Photodynamic Therapy Research Studies
- Bee Products Chemical Analysis
- Connective tissue disorders research
- TGF-β signaling in diseases
- Luminescence and Fluorescent Materials
- Regulation of Appetite and Obesity
- Microbial Metabolism and Applications
- Clostridium difficile and Clostridium perfringens research
- Seaweed-derived Bioactive Compounds
- Neuroendocrine regulation and behavior
- Fungal Biology and Applications
- Inflammasome and immune disorders
Nankai University
2024-2025
Sichuan University of Science and Engineering
2025
Zunyi Medical University
2025
Xi'an Jiaotong University
2025
Sichuan University
2024
State Key Laboratory of Oral Diseases
2024
Mudanjiang Medical University
2018-2024
Fudan University
2021-2023
Zhongshan Hospital
2023
State Key Laboratory of Medical Neurobiology
2021-2022
The lateral hypothalamus (LH) is physiologically critical in brain functions. LH also plays an important role drug addiction. However, neural circuits underlying involvement of addiction remain obscure. In the present study,our results showed that male mice, during context-induced expression morphine withdrawal memory, glutamatergic neurons played role; dopamine D1 receptor-expressing medium spiny (D1-MSNs) projecting from core nucleus accumbens (NAcC) to were upstream circuit activate...
RNA modifications, such as N6‐methylation of adenosine (m6A), serve key regulators cellular behaviors, and are highly dynamic; however, tools for dynamic monitoring modifications in live cells lacking. Here, we develop a genetically encoded live‐cell methylation sensor that can dynamically monitor m6A level at single‐cell resolution. The senses via affinity‐induced cytoplasmic retention using nuclear location sequence‐fused reader. It allows simultaneously measure dynamics viral invasion...
ABSTRACT Dysregulated transforming growth factor beta (TGF-β) signaling is associated with a spectrum of osseous defects as seen in Loeys-Dietz syndrome, Marfan and Camurati-Engelmann disease. Intriguingly, neurofibromatosis type 1 (NF1) patients exhibit many these characteristic skeletal features, including kyphoscoliosis, osteoporosis, tibial dysplasia, pseudarthrosis; however, the molecular mechanisms mediating phenotypes remain unclear. Here, we provide genetic pharmacologic evidence...
The present study aimed to investigate bone deterioration in glucocorticoid‑induced osteoporosis (GIOP) mice, and the anti‑osteoporosis effect underlying molecular mechanism of icariin. Dexamethasone (DSM) treatment was demonstrated facilitate induction hypercalciuria GIOP mice. Icariin reversed dexamethasone (DXM)‑induced disequilibrium calcium homeostasis resorption, increased serum alkaline phosphatase, tartrate resistant acid osteocalcin deoxypyridinoline. Haematoxylin eosin staining...
RNA modifications, such as N6‐methylation of adenosine (m6A), serve key regulators cellular behaviors, and are highly dynamic; however, tools for dynamic monitoring modifications in live cells lacking. Here, we develop a genetically encoded live‐cell methylation sensor that can dynamically monitor m6A level at single‐cell resolution. The senses via affinity‐induced cytoplasmic retention using nuclear location sequence‐fused reader. It allows simultaneously measure dynamics viral invasion...
The occurrence and development of colorectal cancer (CRC) is an incredibly long process that involves continuous changes in the tumor microenvironment. These constant may ultimately result genetic alterations metabolic processes some symbiotic bacteria as a way to adapt changing environment. Patients with CRC exhibit altered abundance Bacteroides fragilis (B. fragilis) indicated by several studies. To better understand genomic characteristics virulence spectrum B. strains tissues, were...
Background Gut microbiota can significantly alter the risk or progression of cancer by maintaining gut immune system homeostasis. However, exact mechanism which and its metabolites influence colorectal tumorigenesis is unclear. Methods The roles tryptophan metabolite indole-3-acetic acid (IAA) in inflammation tumor development were investigated dextran sodium sulfate (DSS) azoxymethane (AOM)-DSS mouse models with without IAA supplementation Lactobacillus reuteri -produced IAA. Pregnane X...
Dictyophora indusiata is commonly utilized as a functional food in China and other Asian countries. The peach-shaped phase of this fungus nutritionally taste-wise similar to its mature fruiting bodies. However, there limited research on the polysaccharides found D. indusiata. A heteropolysaccharide was extracted from volva (DIVP). Analyses using high-performance gel permeation chromatography, methylation NMR revealed that DIVP comprises glucose, glucuronic acid, galactose, mannose. Its...
Rheumatoid arthritis (RA) is an autoimmune disorder causing chronic inflammation in the small joints of articular bone and destruction cartilage. RA causes stiffness, pain, joint destruction, substantial comorbidity, functional disability. Early-stage diagnosis can help treatment disease expand patient life span. Interleukins are a group inflammatory cytokines; particular, abundance interleukin-6 (IL-6) was found synovial fluid serum. In patients, levels IL-6 have been to be correlated with...
Osteoporosis and osteoarthritis are orthopedic disorders that affect millions of elderly people worldwide; stimulation bone formation is a potential therapeutic strategy for the treatment these conditions. As only bone-forming cells, osteoblasts play key role in reconstruction. The microRNA miR-17-3p downregulated during osteogenic differentiation human marrow mesenchymal stem but its precise this process unknown. Here, we investigated osteoblast differentiation. An vitro model osteogenesis...
Peristaltic movements in gut are essential to propel ingested materials through the gastrointestinal tract.Intestinal resident macrophages play an important role this physiological function protecting enteric neurons.However, it is incompletely clear how individuals maintain homeostasis of motility.Here we found that NLRP3 a critical factor controlling loss muscularis (MMs), and demonstrate MMs involved excitatory neurons such as choline acetyltransferase (ChAT) + vesicular glutamate...
Gut microbiota/metabolites not only participate in the food and energy metabolism but also contribute to host immune response homeostasis. The alternation of gut has been widely related intestinal extra-intestinal disorders such as bowel diseases (IBDs). Bactericidal substances from epithelial cells can regulate composition microbiota. However, effects regenerating protein 4 (REG4) (human)/(Reg4) (mice), a potentially bactericidal substance cells, on homeostasis maintain elusive. Here, we...
Increasing evidence has suggested that microRNAs (miRNAs; miRs) are extensively involved in the progression of chondrosarcoma (CHS). However, few studies have investigated functional role miR-525 CHS tissues and cells. In present study, it was discovered levels were decreased Dual luciferase assays indicated F-spondin 1 (SPON1) is a target gene microRNA (miR)-525. addition, overexpression suppressed SW1353 cell migration invasion enhanced apoptosis. Increased SPON1 expression identified...
The process through which early memories are transferred to the cerebral cortex form long-term is referred as memory consolidation, and basolateral amygdala (BLA) an important brain region involved in this process. Although functional connections between BLA multiple regions critical for consolidation of withdrawal memory, whether projection from anterior cingulate (ACC) formation or remains unclear. In paper, we used a chemical genetic method specifically label BLA-ACC combined morphine...
Osteogenic differentiation is an important process of new bone formation, microRNA-409-3p (miR-409-3p) has been reported to be up-regulated in the osteogenic human marrow mesenchymal stem cells (MSCs). The present study aimed investigate regulatory effect miR-409-3p on MSCs and its molecular mechanism. expression osteoblast (human skull osteoblast, HCO) marrow-derived (MSC-A, MSC-B, MSC-U) were detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). binding...
Abstract Chronic morphine administration alters gene expression in different brain regions, an effect which may contribute to plastic changes associated with addictive behavior. This change is most possibly mediated by drug-induced epigenetic remodeling of programs. Our previous studies showed that chronic morphine-induced decrease miR-105 the medial prefrontal cortex (mPFC) contributed context-induced retrieval withdrawal memory. However, how treatment decreases mPFC still remains unknown....
Abstract Inflammasome NLRC4 (NLR family CARD domain containing 4) can protect mucosal barriers such as intestine from invading bacterial pathogens. However, it was incompletely clear how activated in intestinal epithelial cells. In this study, we demonstrated that LNCGM1082 could mediate the activation of via binding with protein kinase C (PKC)δ. knockout (KO) mice had reduced resistance against Salmonella Typhimurium infection, well impaired expulsion infected gut cells and release IL-18...