A5103214909- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Immune cells in cancer
- Global Cancer Incidence and Screening
- Gastric Cancer Management and Outcomes
- Actinomycetales infections and treatment
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Colorectal and Anal Carcinomas
- Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Multiple and Secondary Primary Cancers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammatory Biomarkers in Disease Prognosis
- Autophagy in Disease and Therapy
- Cardiac tumors and thrombi
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Peking University
2025
Peking University Cancer Hospital
2025
Shandong First Medical University
2023
Capital Medical University
2022-2023
Beijing Chao-Yang Hospital
2023
Shandong Provincial Hospital
2023
Peking Union Medical College Hospital
2023
National Clinical Research
2022
Northwestern University
2019
We comprehensively analyzed the global burdens and trends in incidence mortality of tracheal, bronchus, lung (TBL) cancer among subgroups distinctive ages genders.We retrieved rates 2020 from GLOBOCAN database 185 countries. The age-standardized (ASRs) were mostly obtained Cancer Incidence Five Continents World Health Organization database, respectively. joinpoint regression analysis has been conducted to evaluate average annual percentage change recent years.Trends decreasing men most...
Neoadjuvant immunotherapy has significantly changed the therapeutic approach for treating patients with surgically resectable non-small cell lung cancer (NSCLC). Here, peripheral blood inflammation-based biomarkers as well previously less focused eosinophil fraction, modified Glasgow prognostic score (mGPS), and nutritional index (PNI) were systematically included to comprehensively analyze their potential in predicting neoadjuvant efficacy prognosis. We enrolled 189 (94 training 95...
A Phase II study was undertaken to evaluate the safety and efficacy of neoadjuvant socazolimab, a novel PD-L1 inhibitor, in combination with nab-paclitaxel cisplatin for locally advanced esophageal squamous cell carcinoma (ESCC).Sixty-four patients were randomly divided between Socazolimab + (TP) arm (n = 32) control 32), receiving either socazolimab (5 mg/kg intravenously (IV), day 1) or placebo (125 mg/m2 IV, 1/8) (75 repeated every 21 days four cycles before surgery. The primary endpoint...
Multimodal epigenetic characterization of cell-free DNA (cfDNA) could improve the performance blood-based early cancer detection. However, integrative profiling cfDNA methylome and fragmentome has been technologically challenging. Here, we adapt an enzyme-mediated methylation sequencing method for comprehensive analysis genome-wide methylation, fragmentation, copy number alteration (CNA) characteristics enhanced We apply this to plasma samples 497 healthy controls 780 patients seven types...
The most common form of treatment for non-metastatic lung cancer is surgery-based combination therapy, which may also include adjuvant radiotherapy or chemotherapy. Second primary malignancies (SPMs) are uncommon but significant radiation side effects in patients with resectable cancer, and SPMs have not been adequately investigated. Our study aims to assess the correlations development cancer.We screened any malignancy that occurred more than five years after diagnosis cancer. Based on...
Neoadjuvant immunochemotherapy (nICT) has dramatically changed the treatment landscape of operable esophageal squamous cell carcinoma (ESCC), but factors influencing tumor response to nICT are not well understood. Here, using single-cell RNA sequencing paired with T receptor sequencing, we profile tissues from ESCC patients accepting and characterize microenvironment context. CXCL13+CD8+ Tex cells, a subset exhausted CD8+ revealed highly infiltrate in pre-treatment tumors show prominent...
Oesophageal cancer is a prevalent and deadly around the world. We aimed to present comprehensive analysis of global geographic patterns temporal trends in mortality incidence oesophageal cancer. The data 2020 were obtained from GLOBOCAN database. Based on World Health Organization (WHO) database Cancer Incidence Five Continents (CI5), we also retrieved age-standardized rates (ASRs) average annual percentage changes (AAPCs) calculated using joinpoint regression analysis. Globally, 0.54...
Abstract Background Radiomics is increasingly utilized to distinguish pulmonary nodules between lung adenocarcinoma (LUAD) and tuberculosis (TB). However, it remains unclear whether different segmentation criteria, such as the inclusion or exclusion of cavity region within nodules, affect results. Methods A total 525 patients from two medical centers were retrospectively enrolled. The radiomics features extracted according regions interest (ROI) criteria. Multiple logistic regression models...
Abstract Autophagy is an essential cellular mechanism that degrades cytoplasmic proteins and organelles to recycle their components. Moreover, autophagy for preimplantation development in mammals. Here we show also important reprogramming somatic cell nuclear transfer (SCNT). Our data indicate unlike fertilized oocytes, not triggered SCNT embryos during 6 hours of activation. Mechanistically, the inhibited autophagic induction activation due cytochalasin B (CB) caused depolymerization actin...
Abstract Accurate presurgical prediction of pathological complete response (pCR) can guide treatment decisions, potentially avoiding unnecessary surgeries and improving the quality life for cancer patients. We developed a minimal residual disease (MRD) profiling approach with enhanced sensitivity specificity detecting tumor DNA from cell-free (cfDNA). The was validated in two independent esophageal squamous cell carcinoma (ESCC) cohorts. In cohort undergoing neoadjuvant, surgical, adjuvant...
Primary pulmonary lymphoma (PPL) is a rare extranodal originating from the lung, accounting for 0.5-1.0% of primary lung malignant tumors. Previous case reports or cohort studies included limited sample size; therefore, understanding disease remains inadequate, and clinical data regarding PPL are limited.Patients with diagnosed histologically radiologically between January 2000 December 2019 at our center were retrospectively analyzed.In total, 90 consecutive cases in this research....
PVR/TIGIT and PD-L1/PD-1 axes play essential roles in tumor immune evasion could be potential targets for combined immunotherapy. We aimed to evaluate the expression status of above-mentioned markers lung squamous cell carcinoma (LUSC), investigate their survival impact relevance with microenvironment clinicopathological features. retrospectively collected specimens from 190 LUSC patients, who underwent pulmonary surgeries, we performed immunohistochemistry assays PVR, TIGIT, PD-L1, PD-1...
The aim of present study was to investigate the efficiency 18F-FDG uptake in predicting major pathological response (MPR) resectable non-small cell lung cancer (NSCLC) patients with neoadjuvant immunotherapy. A total 104 stage I-IIIB NSCLC were retrospectively derived from National Cancer Center China, which 36 cases received immune checkpoint inhibitors (ICIs) monotherapy (I-M) and 68 ICI combination therapy (I-C). PET-CT scans performed at baseline after (NAT). Receiver‐operating...
Abstract Backgrounds The characteristics of programmed cell death protein-1 (PD-L1) expression, tumor-infiltrating lymphocytes (TILs), and tumor microenvironment (TME) in lung adenocarcinoma (LUAD) patients are closely related to immunotherapy, there differences between Asians Caucasians. Methods Acquire the transcriptome data Cancer Genome Atlas Chinese LUAD patients. R software was used analyze differential expression genes, prognosis, gene function. Use CIBERSORT for TIL-related analysis...
Immunotherapy has been proven effective among several human cancer types, including Squamous cell lung carcinoma (SqCLC). ERAP2 plays a pivotal role in peptide trimming of many immunological processes. However, the prognostic and its relationship with immune infiltration SqCLC remains unclear. The differential expression was identified via GEO TCGA databases. We calculated impact on clinical prognosis using Kaplan-Meier plotter. TIMER applied to evaluate abundance cells markers. tissue...
Abstract Background Recent studies indicated that T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) cluster of differentiation 47 (CD47) have emerged as new potential immunotherapy targets. However, the roles TIGIT CD47 in lung squamous carcinoma (LUSC) not been fully illustrated. Methods The specimens clinicopathological information from 190 LUSC patients who underwent surgeries our center were retrospectively collected. Immunohistochemical staining for was conducted....
Abstract Background In China, real‐world data on surgical challenges and postoperative complications after neoadjuvant immunotherapy of lung cancer are limited. Methods Patients were retrospectively enrolled from January 2018 to 2023, their clinical pathological characters subsequently analyzed. Surgical difficulty was categorized into a binary classification according duration: challenging or routine. Postoperative graded using Clavien–Dindo grades. Logistic regression used identify risk...