A5015060525- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Lung Cancer Research Studies
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Neuroendocrine Tumor Research Advances
- Protease and Inhibitor Mechanisms
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Cancer Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Advanced Biosensing Techniques and Applications
- Extracellular vesicles in disease
- Traditional Chinese Medicine Studies
- Cancer Cells and Metastasis
- Advanced biosensing and bioanalysis techniques
- Inflammasome and immune disorders
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Northeastern University
2023-2024
Chinese Academy of Sciences
2023
Shanghai Institute of Materia Medica
2023
Cancer Hospital of Chinese Academy of Medical Sciences
2020
National Cancer Center
2020
Ningxia Medical University
2008-2009
Yinchuan First People's Hospital
2008
Abstract Background Lung adenocarcinomas (LUAD) is the most common histological subtype of lung cancers. Tumor immune microenvironment (TIME) involved in tumorigeneses, progressions, and metastases. This study aimed to develop a robust immune‐related signature LUAD. Methods A total 1774 LUAD cases sourced from public databases were included this study. Immune scores calculated through ESTIMATE algorithm weighted gene co‐expression network analysis (WGCNA) was applied identify genes....
Background Esophageal squamous cell carcinoma (ESCC) is one of the most common cancer types and represents a threat to global public health. N6-Methyladenosine (m6A) methylation plays key role in occurrence development many tumors, but there are still few studies investigating ESCC. This study attempts construct prognostic signature ESCC based on m6A RNA regulators explore potential association these with tumor immune microenvironment (TIME). Methods The transcriptome sequencing data...
Abstract Background Maintenance of cancer stem‐like cell (CSC) stemness supported by aberrantly regulated metabolism is critical for CSC self‐renewal and tumor progression. As a key glycolytic enzyme, hexokinase 2 (HK2) plays an instrumental role in aerobic glycolysis However, whether HK2 directly contribute to maintenance small lung (SCLC) largely unclear. In this study, we aimed investgate independent its activity involved SCLC. Methods Immunoblotting analyses were conducted determine the...
// Wei Guo 1 , Pan Wang Ning Li Fei Shao Hao Zhang Zhenlin Yang Renda Yibo Gao and Jie He Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy Medical Sciences Peking Union College, Beijing 10021, The People's Republic China Correspondence to: He, email: prof.hejie@263.net Gao, gaoyibo@cicams.ac.cn Keywords: esophageal squamous cell carcinoma; prognostic value; programmed death receptor 1; ligand meta-analysis Received: August 15, 2017 Accepted: November...
Cancer cell-specific variation and circulating tumour DNA (ctDNA) methylation are promising biomarkers for non-invasive cancer detection molecular classification. Nevertheless, the applications of ctDNA to early screening remain highly challenging due scarcity ctDNA, low signal-to-noise ratio variation, lack non-locus-specific technologies.
Abstract Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of lung cancer with poor prognosis. Here, we perform multi-omics analysis 56 PSC samples, 14 which are microdissected to analyze intratumoral heterogeneity. We report the mutational landscape PSC. The epithelial and components share numerous genomic alterations, indicating common progenitor. find that epithelial-mesenchymal transition (EMT) plays important roles in carcinogenesis pan-cancer reveals high tumor mutation burden...
Abstract Primary small cell carcinoma of the esophagus (PSCCE) is a lethal neuroendocrine carcinoma. Previous studies proposed genetic similarity between PSCCE and esophageal squamous (ESCC) but provided little evidence for differences in clinical course differentiation. We perform whole-exome sequencing, RNA sequencing immunohistochemistry profiling on 46 cases. Integrated analyses enable discovery multiple mechanisms RB1 disruption 98% (45/46) The transcriptomic landscape closely resembles...
Human epidermal growth factor receptor 2 (HER2) may serve as a valid target for diagnosis of cancer. The probes with capability near-infrared window one region II (NIR-II) and positron emission tomography (PET) dual-modal imaging are highly desired HER2-positive tumor detection. Herein, three HER2-targeted peptides were designed further modified indocyanine green (ICG) 2,2′,2″,2″-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA), which used NIR-II complexation 68Ga...
As an important cancer-associated fibroblast-specific biomarker, fibroblast activation protein (FAP) has become attractive target for tumor diagnosis and treatment. However, most FAP-based radiotracers showed inadequate uptake short retention in tumors. In this study, we designed synthesized a novel FAP ligand (DOTA-GPFAPI-04) through assembling three functional moieties: quinoline-based inhibitor specifically targeting FAP, substrate Gly–Pro as linker increasing the interaction,...
Abstract Purpose Since mediastinal lymph node dissection and radiotherapy (RT) have potential unclear impacts on pulmonary lymphatic system, this study aimed to assess the effectiveness of immune checkpoint inhibitors (ICIs) in recurrent/metastatic non‐small‐cell lung cancer (NSCLC) patients who previously received radical surgery with or without thoracic RT. Methods Clinical data underwent lobectomy systematic lymphadenectomy (2000.1.1–2021.7.2) immunotherapy after progression were...
USP13 is significantly amplified in over 20% of lung cancer patients and critical for tumor progression. However, the functional role small cell (SCLC) remains largely unclear. In this study, we found that deubiquitinase highly expressed SCLC samples positively associated with poor prognosis multiple cohorts. vitro vivo depletion inhibited stem cells (CSCs) properties tumorigenesis, inhibitory effect was rescued by reconstituted expression wide type (WT) but not enzyme-inactive mutant....
Molecular targets serve a crucial role in drug development. Herein, we discovered novel peptide that can specifically target the human epidermal growth factor receptor 2 (HER2) and thus named it Herceptide. In our study, Herceptide was conjugated to near-infrared fluorescent dye indocyanine green (ICG) obtain probe, ICG-Herceptide. Importantly, specific binding HER2 revealed by molecular docking, surface plasmon resonance analysis, competition assays. The probe showed high affinity (KD =...
Lung adenocarcinoma (LUAD) accounts for an increasing proportion of non-small-cell lung cancer and number cancer-related deaths worldwide. However, few biomarkers are available prognosis patient stratification. In all eight datasets from the Oncomine The Cancer Genome Atlas (TCGA) LUAD cohorts, solute carrier family 2 member 1 (SLC2A1) was significantly more highly expressed in tissue than normal tissue. High SLC2A1 expression also (p < 0.05) associated with a poor stage I, II, III subgroups...
Abstract Backgroud Recent studies have indicated that programmed cell death‐ligand 1 (PD‐L1) and cluster of differentiation 47 (CD47) play an essential role in tumor immune evasion may serve as potential targets for combined immunotherapy. The aim our study was to evaluate the PD‐L1/CD47 expression status lung squamous carcinoma (LUSC) adenocarcinoma (LUAD), explore its survival impact relevance with microenvironment. Methods specimens from 190 LUSC 240 LUAD patients who underwent...
Abnormal metabolism is one of the hallmarks cancer cells. Monoacylglycerol lipase (MGLL), a key enzyme in lipid metabolism, has emerged as an important regulator tumor progression. In this study, we aimed to characterize role MGLL development lung adenocarcinoma (LUAD). To end, used tissue microarrays evaluate expression LUAD and assessed whether levels protein are correlated with clinicopathological characteristics LUAD. We found that higher samples than adjacent non-tumor tissues....
The ability of lung cancer screening to manage pulmonary nodules was limited because the high false-positive rate in current mainstream method, low-dose computed tomography (LDCT). We aimed reduce overdiagnosis Chinese population.Lung risk prediction models were constructed using data from a population-based cohort China. Independent clinical two programs performed Beijing and Shandong, respectively, used as external validation set. Multivariable logistic regression estimate probability...
Ferroptosis is a newly discovered type of programmed cell death that differs from canonical apoptosis. However, the potential role ferroptosis in lung adenocarcinoma (LUAD) has not been elaborated. In total, 1,328 samples databases and 36 regulators were included this study. By combining random survival forest principal component analysis algorithms, robust prognostic ferroptosis-related risk score (FRRS) was constructed, performance validated three independent datasets. Based on median...
Fibroblast activation protein (FAP) has recently gained significant attention as a promising tumor biomarker for both diagnosis and therapeutic applications. A series of radiopharmaceuticals based on fibroblast inhibitors (FAPIs) have been developed translated into the clinic. Though some them such radiolabeled FAPI-04 probes achieved favorable in vivo imaging performance, further improvement is still highly desired obtaining with high theranostics potential. In this study, we innovatively...
Immunotherapy has been proven effective among several human cancer types, including Squamous cell lung carcinoma (SqCLC). ERAP2 plays a pivotal role in peptide trimming of many immunological processes. However, the prognostic and its relationship with immune infiltration SqCLC remains unclear. The differential expression was identified via GEO TCGA databases. We calculated impact on clinical prognosis using Kaplan-Meier plotter. TIMER applied to evaluate abundance cells markers. tissue...