A5092150480- Oxidative Organic Chemistry Reactions
- Protease and Inhibitor Mechanisms
- Chemical Synthesis and Analysis
- Peptidase Inhibition and Analysis
- Radical Photochemical Reactions
- Plant-derived Lignans Synthesis and Bioactivity
- Chemical synthesis and alkaloids
- Magnolia and Illicium research
Institute of Organic Chemistry with Centre of Phytochemistry
2025
Kunming Institute of Botany
2023-2025
Chinese Academy of Sciences
2023-2024
University of Chinese Academy of Sciences
2023-2024
Nanjing University of Chinese Medicine
2024
Shanghai Institute of Materia Medica
2024
A stereocontrolled asymmetric total synthesis of the Schisandra nortriterpenoid (+)-rubriflordilactone employing Krische's Ir-catalyzed 2-(alkoxycarbonyl)allylation for late-stage γ-butenolide formation is described. Additional noteworthy aspects include integration Carreira's Ir/amine dual-catalyzed allylation, Suzuki coupling, and Catellani reaction, resulting in an indane iodide. The alkylation lactone 7, followed by RCM, A-ring via condensation B-ring with Bestmann ylide, Morken's...
Metallaphotoredox-enabled deoxygenative arylation of alcohols is a recently developed robust synthetic strategy for sp2-sp3 coupling by MacMillan. Inspired this method, we report herein its first utilization in natural product total synthesis through realizing the 4-bromo-quinoline or 4-bromo-6-methoxyquinoline with quincorine quincoridine, respectively. The were de novo synthesized racemic form key step intramolecular Diels-Alder reaction an enantioselective manner Ir/amine dual-catalyzed...
Fibroblast activation protein (FAP) has recently gained significant attention as a promising tumor biomarker for both diagnosis and therapeutic applications. A series of radiopharmaceuticals based on fibroblast inhibitors (FAPIs) have been developed translated into the clinic. Though some them such radiolabeled FAPI-04 probes achieved favorable in vivo imaging performance, further improvement is still highly desired obtaining with high theranostics potential. In this study, we innovatively...