A5102949694- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Lung Cancer Research Studies
- Ubiquitin and proteasome pathways
- Metabolism, Diabetes, and Cancer
- Neuroendocrine Tumor Research Advances
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- HVDC Systems and Fault Protection
- Glycosylation and Glycoproteins Research
- Immune cells in cancer
- Lipid metabolism and biosynthesis
- Genetic Syndromes and Imprinting
- Neuroblastoma Research and Treatments
- Histone Deacetylase Inhibitors Research
- Protein Tyrosine Phosphatases
- Pancreatic function and diabetes
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
First Affiliated Hospital of Dalian Medical University
2021
Dalian Medical University
2021
Wuxi People's Hospital
2021
Abstract The adenomatous polyposis coli ( APC ) is a frequently mutated tumour suppressor gene in cancers. However, whether regulated at the epitranscriptomic level remains elusive. In this study, we analysed TCGA data and separated 200 paired oesophageal squamous cell carcinoma (ESCC) specimens their adjacent normal tissues demonstrated that methyltransferase-like 3 (METTL3) highly expressed tissues. m 6 A-RNA immunoprecipitation sequencing revealed METTL3 upregulates A modification of ,...
FTO removes the N6-methyladenosine (m6A) modification from genes and plays a critical role in cancer development. However, mechanisms underlying regulation of its subsequent impact on epitranscriptome remain to be further elucidated. Here, we demonstrate that expression is downregulated inversely correlated with poor survival lung adenocarcinoma patients. Mechanistically, Wnt signaling induces binding EZH2 β-catenin. This protein complex binds LEF/TCF-binding elements at promoter region FTO,...
Abstract Background Maintenance of cancer stem‐like cell (CSC) stemness supported by aberrantly regulated metabolism is critical for CSC self‐renewal and tumor progression. As a key glycolytic enzyme, hexokinase 2 (HK2) plays an instrumental role in aerobic glycolysis However, whether HK2 directly contribute to maintenance small lung (SCLC) largely unclear. In this study, we aimed investgate independent its activity involved SCLC. Methods Immunoblotting analyses were conducted determine the...
The Warburg effect is a key metabolic feature of cancer cells and manifests as substantially increased glycolysis regardless the presence oxygen [1]. initial step catalyzed by hexokinase (HK), which converts glucose to intermediate glucose-6-phosphate (G-6-P). Four kinds HK isozymes, HK1, HK2, HK3 HK4, have been found in mammals. HK1 HK2 bind mitochondrial outer membrane through interactions with voltage-dependent anion channels (VDACs), both these molecules high affinity for [2]....
Abstract Background Cancer cells reprogram metabolism for proliferation. Phosphoglycerate kinase 1 (PGK1), as a glycolytic enzyme and newly identified protein kinase, coordinates glycolysis mitochondrial metabolism. However, the clinical significance of PGK1 expression function in cancer progression is unclear. Here, we investigated relationship between prognosis multiple types its regulation. Methods We performed pan‐cancer analyses mRNA level DNA methylation 11,908 tumor tissues 1582...
Background: The identification of prognostic markers for non-small-cell lung carcinoma (NSCLC) is needed clinical practice. metabolism-reprogramming marker ketohexokinase (KHK)-A and acetyl-CoA synthetase 2 (ACSS2) phosphorylation at S659 (ACSS2 pS659) play important roles in tumorigenesis tumor development. However, the significance KHK-A ACSS2 pS659 NSCLC largely unknown. Methods: expression levels were assessed by immunohistochemistry analyses surgical specimens from 303 patients. values...
For lung adenocarcinoma (LUAD), patients of different stages have strong heterogeneity, and their overall prognosis varies greatly. Thus, exploration novel biomarkers to better clarify the characteristics LUAD is urgent. Multi-omics information were collected form TCGA. Three independent cohorts obtained from gene expression omnibus (GEO). A multi-omics correlation analysis METTL5 was performed in TCGA dataset. To build a -associated prognostic score (MAPS). Spathial random forest methods...
USP13 is significantly amplified in over 20% of lung cancer patients and critical for tumor progression. However, the functional role small cell (SCLC) remains largely unclear. In this study, we found that deubiquitinase highly expressed SCLC samples positively associated with poor prognosis multiple cohorts. vitro vivo depletion inhibited stem cells (CSCs) properties tumorigenesis, inhibitory effect was rescued by reconstituted expression wide type (WT) but not enzyme-inactive mutant....
Ferroptosis is a newly discovered type of programmed cell death that differs from canonical apoptosis. However, the potential role ferroptosis in lung adenocarcinoma (LUAD) has not been elaborated. In total, 1,328 samples databases and 36 regulators were included this study. By combining random survival forest principal component analysis algorithms, robust prognostic ferroptosis-related risk score (FRRS) was constructed, performance validated three independent datasets. Based on median...
Metabolic enzymes can perform non-metabolic functions and play critical roles in the regulation of a variety important cellular activities. Phosphoenolpyruvate carboxykinase 1 (PCK1), gluconeogenesis enzyme, was recently identified as an AKT-regulated protein kinase that phosphorylates INSIG1/2 to promote nuclear SREBP1-dependent lipogenesis. However, relationship this with progression non-small-cell lung carcinoma (NSCLC) is unclear. Here, we demonstrate epidermal growth factor receptor...
Background Rapid tumor growth inevitably results in energy stress, including deficiency of glutamine, a critical amino acid for cell proliferation. However, whether glutamine allows cells to use lipid droplets as an resource and the mechanism underlying this potential regulation remain unclear. Methods We purified from H322 H358 human non-small-cell lung cancer (NSCLC) under deprivation conditions performed immunoblotting determine binding choline kinase (CHK) α2 droplets. Immunofluorescence...
Due to lack of estrogen receptor α (ERα, gene name: ESR1), ERα-negative breast carcinoma is insensitive endocrine therapy, and restoration ERα has become a promising strategy for cancer treatment. Sesamol, naturally occurring phenolic compound, usually extracted from sesame seeds. Previous investigations have unmasked its anti-oxidant anti-inflammation properties. In this study, sesamol induced functional re-expression followed by upregulation downstream pS2 GREB1 genes in carcinoma....
Background: Small-cell lung cancer (SCLC) is a type of with high invasiveness and poor prognosis. Although SCLC effective for initial treatment, the vast majority patients will relapse, efficacy posterior line therapy limited, there lack treatment. At same time, in past 30 years, has been little progress first-line With antiangiogenic therapy, whether it can be used treatment worth exploring. Therefore, single-arm multicenter clinical study was conducted on efficacy, optimization, safety...
The iron-dependent cell death named ferroptosis has been implicated in the progression and therapeutic response of several tumors. However, potential role lung adenocarcinomas (LUAD) remained less well understood. In TCGA-LUAD cohort, unsupervised clustering was first conducted based on regulators extracted from FerrDb database. Comprehensive correlation analysis comparisons were performed among subtypes. ferroptosis-related prognostic (FRP) signature identified filtered features repeated...
Background: Cancer cells reprogram metabolism for proliferation. Phosphoglycerate kinase 1 (PGK1), as an aerobic glycolytic enzyme and a protein kinase, coordinates glycolysis mitochondrial in glioblastoma multiforme cells. However, the clinical significance of PGK1 most types cancer is largely unknown.Methods: We performed Pan-Cancer analyses mRNA expression DNA methylation 11,908 tumours 1582 paired non-tumour tissues across 34 The Genome Atlas datasets. Using specific antibodies against...