A5100390930- Plant Molecular Biology Research
- Plant Reproductive Biology
- Photosynthetic Processes and Mechanisms
- DNA Repair Mechanisms
- Chromosomal and Genetic Variations
- Plant tissue culture and regeneration
- Plant Gene Expression Analysis
- Plant Stress Responses and Tolerance
- Plant Virus Research Studies
- Microtubule and mitosis dynamics
- Plant biochemistry and biosynthesis
- Cancer-related molecular mechanisms research
- Plant nutrient uptake and metabolism
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Plant-Microbe Interactions and Immunity
- Genomics and Chromatin Dynamics
- Mitochondrial Function and Pathology
- CRISPR and Genetic Engineering
- Research in Cotton Cultivation
- Machine Learning in Bioinformatics
- Virus-based gene therapy research
- Ubiquitin and proteasome pathways
- Plant Pathogens and Fungal Diseases
- Genetic Mapping and Diversity in Plants and Animals
Chongqing Medical University
2022-2025
Northwest A&F University
2016-2025
Southern University of Science and Technology
2024-2025
Henan Agricultural University
2025
Sun Yat-sen University
2012-2025
Chongqing Normal University
2023-2025
Beckman Research Institute
2024-2025
Chinese Academy of Agricultural Sciences
2017-2025
City of Hope
2024-2025
Shandong Agricultural University
2025
In meiotic prophase, synaptonemal complexes (SCs) closely appose homologous chromosomes (homologs) along their length. SCs are assembled from two axial elements (AEs), one each homolog, which connected by numerous transverse filaments (TFs). We disrupted the mouse gene encoding TF protein Sycp1 to analyze role of TFs in chromosome behavior and recombination. -/- mice infertile, but otherwise healthy. spermatocytes form normal AEs, align homologously, do not synapse. Most arrest pachynema,...
The Monocyte chemoattractant protein-1 (MCP-1), also referred to as chemokine ligand 2 (CCL2), belongs the extensive family and serves a crucial mediator of innate immunity tissue inflammation. It has notable impact on inflammatory conditions affecting kidneys. Upon binding its receptor, MCP-1 can induce lymphocytes NK cells’ homing, migration, activation, differentiation, development while promoting monocytes’ macrophages’ infiltration, thereby facilitating kidney disease-related As...
Aneuploidy (trisomy or monosomy) is the leading genetic cause of pregnancy loss in humans and results from errors meiotic chromosome segregation. Here, we show that absence synaptonemal complex protein 3 (SCP3) promotes aneuploidy murine oocytes by inducing defective The abnormal oocyte karyotype inherited embryos, which die utero at an early stage development. In addition, embryo death SCP3 -deficient females increases with advancing maternal age. We found required for chiasmata formation...
Abstract The sperm cell of flowering plants cannot migrate unaided and must be transported by the pollen tube male gametophyte to achieve successful fertilization. Long-distance guidance is controlled seven-celled female gametophyte, embryo sac. Previous reports showed that synergid sac essential for guidance. Here, we report identification a central (ccg) mutant, which defective in micropylar CCG encodes nuclear protein with an N-terminal conserved zinc β-ribbon domain functionally...
Significance Adzuki bean ( Vigna angularis ) is distinct in its high starch and low fat accumulation. However, the underlying genetic basis still not well understood. In this study, we generated a high-quality draft genome sequence of adzuki by using whole-genome shotgun sequencing strategy. By comparative genomic transcriptome analyses, demonstrated that significant difference content between soybean were caused transcriptional abundance rather than copy number variations genes related to...
Cotton is an important industrial crop worldwide and upland cotton (Gossypium hirsutum L.) most widely cultivated in the world. Due to ever-increasing water deficit, drought stress brings a major threat production. Thus, it reveal genetic basis under develop tolerant cultivars. To address this issue, present study, 319 accessions were genotyped by 55,060 single nucleotide polymorphisms (SNPs) from high-density CottonSNP80K array phenotyped nine tolerance related traits. The two datasets used...
Many plant receptor kinases transduce signals through receptor-like cytoplasmic (RLCKs); however, the molecular mechanisms that create an effective on-off switch are unknown. The kinase BR INSENSITIVE1 (BRI1) transduces brassinosteroid (BR) signal by phosphorylating members of BR-signaling (BSK) family RLCKs, which contain a domain and C-terminal tetratricopeptide repeat (TPR) domain. Here, we show signaling function BSKs is conserved in Arabidopsis (Arabidopsis thaliana) rice (Oryza sativa)...
Copper (Cu) is an essential micronutrient for plant growth. However, the molecular mechanisms underlying Cu trafficking and distribution to different organs in rice (Oryza sativa) are poorly understood. Here, we report function role of Antioxidant Protein1 (OsATX1), a chaperone rice. Knocking out OsATX1 resulted increased concentrations roots, whereas overexpression reduced root but accumulation shoots. At reproductive stage, developing tissues, including panicles, upper nodes internodes,...
In comparison with general FISH for preparing probes in terms of time and cost, synthesized oligonucleotide (oligo hereafter) have many advantages such as ease design, synthesis, labeling. Low cost high sensitivity resolution oligo greatly simplify the procedure a simple, fast, efficient method chromosome identification. this study, we developed new multiplex to accurately efficiently distinguish wheat (Triticum aestivum, 2n = 6x, AABBDD) Thinopyrum bessarabicum (2n 2x 14, JJ) chromosomes....
Abstract Melatonin is a pleiotropic signaling molecule that regulates plant growth and responses to various abiotic stresses. The last step of melatonin synthesis in plants can be catalyzed by caffeic acid O -methyltransferase (COMT), multifunctional enzyme reported have N -acetylserotonin (ASMT) activity; however, the ASMT activity COMT has not yet been characterized nonmodel such as watermelon ( Citrullus lanatus ). Here, total 16 putative O-methyltransferase ClOMT ) genes were identified...
Water shortage, excessive fertilization and improper variety selection have seriously restricted the sustainable development of potato in Northwest China. Two-year field experiments were conducted 2021 2022 to explore effects irrigation amount fertilizer application rate on growth, yield, nutrient uptake, quality, water, use efficiency, soil enzyme activity economic benefits different varieties. Three levels W1 (100% crop evapotranspiration (ETC)), W2 (80% ETC) W3 (60% ETC). rates F1 (240 kg...
Neoadjuvant immunotherapy has significantly changed the therapeutic approach for treating patients with surgically resectable non-small cell lung cancer (NSCLC). Here, peripheral blood inflammation-based biomarkers as well previously less focused eosinophil fraction, modified Glasgow prognostic score (mGPS), and nutritional index (PNI) were systematically included to comprehensively analyze their potential in predicting neoadjuvant efficacy prognosis. We enrolled 189 (94 training 95...
Immune checkpoint blockade (ICB) therapy potently revives T cell's response to cancer. However, patients suffered with tumors that had inadequate infiltrated immune cells only receive limited therapeutic benefits from ICB therapy. Synthetic biology promotes the alternative strategy of harnessing tumor-targeting bacteria synthesize therapeutics modulate immunity in situ. Herein, we engineered attenuated Salmonella typhimurium VNP20009 gene circuits synthetize granulocyte-macrophage...
Abstract Chronic inflammation and dyslipidemia are important risk factors in developing atherosclerotic cardiovascular disease, such as coronary heart disease. Acute syndrome (ACS) is one of the most dangerous syndromes Type 2 diabetes mellitus (T2DM) considered equal to disease owing high cardiac induced by chronic dyslipidemia. The neutrophil high-density lipoprotein cholesterol ratio (NHR) a novel straightforward marker that reflects lipid metabolic disorder. However, few studies have...
In this work, an electrochemiluminescence (ECL) quenching system using multimetal–organic frameworks (MMOFs) was proposed for the sensitive and specific detection of heart-type fatty acid-binding protein (H-FABP), a marker acute myocardial infarction (AMI). Bimetallic MOFs containing Ru Mn as metal centers were synthesized via one-step hydrothermal method, yielding RuMn ECL emitter. The not only possessed strong performance Ru(bpy)32+ but also maintained high porosity original active sites...
Recent observational studies revealed an association between gut microbiota and aging, but whether are causally associated with the aging process remains unknown. We used a two-sample Mendelian randomization approach to investigate causal biological age acceleration using largest available GWAS summary data from MiBioGen consortium on acceleration. further conducted sensitivity analysis MR-PRESSO, MR-Egger regression, Cochran Q test, reverse MR analysis. Streptococcus (IVW, β = 0.16, p...
Although childhood maltreatment (CM) is widely recognized as a transdiagnostic risk factor for various internalizing and externalizing psychological disorders, the neural basis underlying this association remain unclear. The potential reasons inconsistent findings may be attributed to involvement of both common specific pathways that mediate influence on emergence psychopathological conditions. This study aimed delineate distinct linking depression aggression. First, we employed...
The behavior of meiotic chromosomes differs in several respects from that their mitotic counterparts, resulting the generation genetically distinct haploid cells. This has been attributed part to a meiosis-specific chromatin-associated protein structure, synaptonemal complex. complex consist two parallel axial elements, each one associated with pair sister chromatids, and transverse filament located between synapsed homologous chromosomes. Recently, different cohesin complex, was shown be...