A5005099065- Proteoglycans and glycosaminoglycans research
- Asthma and respiratory diseases
- Glycosylation and Glycoproteins Research
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Sinusitis and nasal conditions
- Protein Structure and Dynamics
- Carbohydrate Chemistry and Synthesis
- MicroRNA in disease regulation
- Dermatology and Skin Diseases
- Advanced biosensing and bioanalysis techniques
- Enzyme Structure and Function
- Tissue Engineering and Regenerative Medicine
- Nasal Surgery and Airway Studies
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Heparin-Induced Thrombocytopenia and Thrombosis
- Electrospun Nanofibers in Biomedical Applications
- Influenza Virus Research Studies
- Computational Drug Discovery Methods
- Adipokines, Inflammation, and Metabolic Diseases
- Protease and Inhibitor Mechanisms
- Head and Neck Cancer Studies
- Mass Spectrometry Techniques and Applications
Rensselaer Polytechnic Institute
2016-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2025
Chongqing Medical University
2016-2025
Xiangya Hospital Central South University
2014-2024
Hohai University
2023-2024
Central South University
2014-2024
Southeast University
2024
Anhui University of Science and Technology
2023
HEC Pharm (China)
2023
Zhejiang University of Technology
2023
A novel method for the estimation of aqueous solubility was solely based on simple atom contribution. Each in a molecule has its own contribution to and developed. Altogether 76 types were used classify atoms with different chemical environments. Moreover, two correction factors, including hydrophobic carbon square molecular weight, account inter-/intramolecular interactions bulkiness effect. The coefficients factors generated multiple linear regression using learning set consisting 1290...
The correlations between Caco-2 permeability (logPapp) and molecular properties have been investigated. A training set of 77 structurally diverse organic molecules was used to construct significant QSAR models for cell permeation. Cellular permeation found depend primarily upon experimental distribution coefficient (logD) at pH = 7.4, high charged polar surface area (HCPSA), radius gyration (rgyr). Among these three descriptors, logD may the largest impact on diffusion through because shows...
Synthetic heparan sulfate protects against drug-induced acute liver failure by inhibiting the proinflammatory activity of HMGB1/RAGE axis.
Allergic rhinitis (AR) is a common inflammation that affects many people globally. Quercetin has anti-allergic biological activity in AR. Here, we aimed to explore the effects of quercetin on type 1 helper T (Th1)/Th2 and regulatory cells (Treg)/Th17 balance. We established an ovalbumin (OVA)-induced mouse model orally administered 20, 35, 50 mg/kg/day quercetin. The nasal symptoms mice were observed. immunoglobulin levels, Treg/Th17-related factors, pro-inflammatory factors examined by...
Heparins have been invaluable therapeutic anticoagulant polysaccharides for over a century, whether used as unfractionated heparin or low molecular weight (LMWH) derivatives. However, production by extraction from animal tissues presents multiple challenges, including the risk of adulteration, contamination, prion and viral impurities, limited supply, insecure supply chain, significant batch-to-batch variability. The use animal-derived also raises ethical religious concerns, well carries...
Abstract Exposure to cockroach allergen is a strong risk factor for developing asthma. Asthma has been associated with allergen-induced airway epithelial damage and heightened oxidant stress. In this study, we investigated allergen–induced oxidative stress in epithelium its underlying mechanisms. We found that extract (CRE) could induce reactive oxygen species (ROS) production, particularly mitochondrial-derived ROS, human bronchial cells. then used the RT2 Profiler PCR array identified...
Abstract Sulfated glycosaminoglycans (GAGs) are a class of important biologics that currently manufactured by extraction from animal tissues. Although such methods unsustainable and prone to contamination, animal-free production have not emerged as competitive alternatives due complexities in scale-up, requirement for multiple stages cost co-factors purification. Here, we demonstrate the development single microbial cell factories capable complete, one-step biosynthesis chondroitin sulfate...
The application of solid-state (SS) nanopore devices to single-molecule nucleic acid sequencing has been challenging. Thus, the early successes in applying SS more difficult class biopolymer, glycosaminoglycans (GAGs), have surprising, motivating us examine potential use an analyze synthetic heparan sulfate GAG chains controlled composition and sequence prepared through a promising, recently developed chemoenzymatic route. A minimal representation data, using only signal magnitude duration,...
Abstract Chronic inflammation and dyslipidemia are important risk factors in developing atherosclerotic cardiovascular disease, such as coronary heart disease. Acute syndrome (ACS) is one of the most dangerous syndromes Type 2 diabetes mellitus (T2DM) considered equal to disease owing high cardiac induced by chronic dyslipidemia. The neutrophil high-density lipoprotein cholesterol ratio (NHR) a novel straightforward marker that reflects lipid metabolic disorder. However, few studies have...
Most proteins are in equilibrium with partially and globally unfolded conformations. In contrast, kinetically stable (KSPs) trapped by an energy barrier a specific state, unable to transiently sample other Among many potential roles, it appears that kinetic stability (KS) is feature used nature allow maintain activity under harsh conditions preserve the structure of prone misfolding. The biological pathological significance KS remains poorly understood because lack simple experimental...
Sepsis induces heparanase-mediated degradation of the endothelial glycocalyx, a heparan sulfate-enriched endovascular layer critical to vascular homeostasis, releasing highly sulfated domains sulfate into circulation. These are oligosaccharides rich in heparin-like trisulfated disaccharide repeating units. Using chemoenzymatic approach, an undecasaccharide containing uniformly
Psilocybin, a naturally occurring hallucinogenic component of magic mushrooms, has significant psychoactive effects in both humans and rodents. But the underlying mechanisms are not fully understood. Blood-oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is useful tool many preclinical clinical trials to investigate psilocybin-induced changes brain activity connectivity (FC) due its noninvasive nature widespread availability. However, fMRI psilocybin on rats...
Cytoplasmic male sterile (CMS) rice Zhenshan 97A (ZS97A) has been widely used in hybrid production China. However, ZS97A suffers from serious panicle enclosure, which blocks normal pollination and greatly reduces seed of rice. Little is known about the cause closure ZS97A. In this study, it was found that occurrence cytoplasmic sterility caused a deficiency indole-3-acetic acid (IAA) panicles, less IAA provided to uppermost internode (UI). Further, decreased panicle-derived gibberellin A1...