A5055746327- Autophagy in Disease and Therapy
- Renal and related cancers
- Ginseng Biological Effects and Applications
- Acute Myeloid Leukemia Research
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
- Lymphoma Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Plant responses to water stress
- Sphingolipid Metabolism and Signaling
- Smart Materials for Construction
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Anesthesia and Sedative Agents
- RNA regulation and disease
- Silicone and Siloxane Chemistry
- Head and Neck Anomalies
- Gastrointestinal Tumor Research and Treatment
- RNA Research and Splicing
- Traditional Chinese Medicine Analysis
- Kawasaki Disease and Coronary Complications
- Peptidase Inhibition and Analysis
- Retinoids in leukemia and cellular processes
- Lysosomal Storage Disorders Research
- Retinal Diseases and Treatments
- Tryptophan and brain disorders
University of Electronic Science and Technology of China
2025
Huazhong University of Science and Technology
2024-2025
Zhejiang University
2014-2025
Union Hospital
2023-2025
Tianjin Medical University General Hospital
2024
Children's Hospital of Zhejiang University
2014-2024
Union Hospital
2024
Xi'an Shiyou University
2024
Ocean University of China
2024
Jilin University
2023
Due to the large surface area-to-volume ratio and rapid electron transfer, two-dimensional (2D) TiO2 nanosheets with ultrathin thicknesses are synthesized by using a bottom-up strategy these self-assembled nanosheet (NS)-based photocatalysts photodetectors were explored for first time. The influence of calcination temperature on microstructures photocatalytic activity discovered presented. as-obtained characterized X-ray diffraction (XRD), scanning microscopy (SEM), transmission (TEM),...
Traditional Chinese medicine Chaihu Shugan San (CSGS) is a classic herb prescription for improving depression, but its specific molecular mechanism has not been fully clarified. This study integrates network pharmacology and experimental validation to investigate CSGS's antidepressant effects, focusing on impact GC metabolism related pathways. In this research, the of CSGS in relation depression model induced by chronic unpredictable mild stress will be discussed. High-performance liquid...
Most randomized trials for acute promyelocytic leukemia (APL) have investigated highly selected patients under idealized conditions, and the findings need to be validated in real world. We conducted a population-based study of all APL Zhejiang Province, China, with total population 82 million people, assess generalization all-trans retinoic acid (ATRA) arsenic as front-line treatment. The outcomes were also analyzed. Between January 2015 December 2019, 1,233 eligible included final analysis....
HDAC7, a member of class IIa HDACs, plays pivotal regulatory role in tumor, immune, fibrosis, and angiogenesis, rendering it potential therapeutic target. Nevertheless, due to the high similarity enzyme active sites inhibitors encounter challenges discerning differences among them. Furthermore, substitution key residue pocket HDACs renders them pseudo-enzymes, leading limited impact enzymatic on their function. In this study, proteolysis targeting chimera (PROTAC) technology was employed...
Cardiovascular damages poses risks to children with Kawasaki disease (KD). Although hypertriglyceridemia and hypercholesteremia are risk factors of cardiovascular damages, studies on the blood lipid metabolism in KD still limited. This study aims analyze lipids coagulation KD. Triglyceride (TG) cholesterol levels plasma serum from 20 were examined comparison 10 healthy (HC) as well high fever identified bacterial infections (BT). Using electrospray ionization mass spectrometry, we profiled...
Neuronal ceroid lipofuscinosis (NCL) is composed of a group inherited neurodegenerative diseases, with the hallmark lipofuscin deposit (a mixture lipids and proteins metal materials) inside lysosomal lumen, which typically emits auto-fluorescence. Adult-onset NCL (ANCL) has been reported to be associated mutation in DNAJC5 gene, including L115R, L116Δ, recently identified C124_C133dup mutation. In this study, we novel C128Y young Chinese female ANCL, caused abnormal palmitoylation triggered deposits.
BACKGROUND The aim of this study was to investigate the effect JAK2/STAT3 pathway on proliferation, cell cycle distribution, apoptosis, and oxidative stress Raji cells via regulating HSP70 expression. MATERIAL AND METHODS were divided into Blank, siRNA, NC AG490 (a signaling inhibitor), siRNA + rh JAK2 (recombinant human JAK2) groups. expression detected by quantitative real-time reverse transcription-PCR (qRT-PCR); levels pathway-related proteins evaluated Western blotting; proliferation...
This study aimed to evaluate the association between triglyceride-glucose (TyG) index and high-sensitivity C-reactive protein-to-albumin ratio (hsCAR) prognosis of patients with STEMI hypertension. A total 699 diagnosed hypertension were included in this database. Compared low TyG group (< 7.8), high (≥ 7.8) was associated an increased risk MACE (HR 2.09, 95% CI = 1.58–2.77; P < 0.001). Similarly, a higher hsCAR 0.15) linked 1.46, 1.12–1.90; 0.005). Subsequently, we categorized population...
Wilms tumor (WT) is the most common kidney cancer in infants and young children. The determination of clonality bilateral WTs critical to treatment, because lineage-independent metastatic tumors may require different treatment strategies. Here we found synchronous WT (n = 24 from 12 patients) responded differently preoperative chemotherapy. Transcriptome, whole-exome whole-genome analysis 6 demonstrated that each side was clonally independent terms somatic driver mutations, copy number...
Objective The prognostic effect of miR-196a/b expression in adult patients with leukaemia remains unclear. This study aimed to determine whether can serve as a factor for acute myeloid leukaemia. Methods We enrolled 124 measured by real-time reverse transcription-polymerase chain reaction. classified into high and low groups based on the median value. Cox regression analyses were carried out assess significance context well-established predictors. Results Patients older age, had higher white...
Autophagy is a physiological pathway characterized by lysosomedependent self-digestion to recycle damaged or superfluous cellular content. Deregulation of autophagy hampers the maintenance homeostasis and contributes tumorigenesis. However, during anticancer therapy, activation development resistance. Thus has been recognized as an important therapeutic target in cancer. Nephroblastoma (Wilm's tumor) common childhood malignancy. The role nephroblastoma largely uninvestigated.This study...
Autophagy is a dynamic process accomplished by the generation and maturation of autophagosomes. Isolation autophagosomes subsequent compositional analysis can provide information about their biogenesis mechanism. In this article, HEK293 cells expressing GFP-LC3 were treated calcium phosphate precipitates (CPP) to induce autophagy. The autophaogomes induced CPP tubular vesicular structures, extensively formed in cytosol. After all membranes cell lysate fractionated differential...
Branchial cleft cysts are congenital diseases of the neck caused by abnormal embryonic development first to fourth branchial clefts. Most found in head and neck, but arising posterior mediastinum rarely reported. We report a 44-year-old Chinese man who was have right-posterior mediastinal mass on chest computed tomography (CT) during physical examination. The size about 30.6 mm * 25.1 enhanced CT showed an occupying lesion right parietal esophagus upper-posterior with no significant...
Abstract to study the influence of steel slag, slag and graphite content age on electrical conductivity concrete, resistivity concrete specimens with specifications A(100mm×100mm×100mm) B(100mm×100mm×400mm) was tested. The results show that: With increase curing cement substitution by slag: continues increase, decrease; optimal blending ratio is 1:2, Larger; as size test piece increases, decreases.
Based on the observation and description of systematic core samples, combined with information evolution lake basins sedimentary background in northwest area Qaidam Basin, it was found that as a whole environment. Accordingly, facies Basin were divided. The main subfacies semi-deep shallow lake. Meanwhile, based distribution lithology, microfacies further divided into algal mat, beach, gray cloud flat muddy flat. Among them, mat distributed very little, more developed; also had special type...
Diffuse large B-cell lymphoma (DLBCL) is a common aggressive non-Hodgkin's (NHL), accounting for 30%-40% of adult NHL. Primary testicular (PT) an uncommon extranodal disease representing approximately 1%-2% lymphoma. Approximately patients are refractory to frontline therapy or relapse after complete remission. Refractory DLBCL responds poorly other lines chemotherapy, and experiences short-term survival.We present 41-year-old male patient who was diagnosed with PT-DLBCL. Further progression...