A5013612077- Metabolism and Genetic Disorders
- Birth, Development, and Health
- Virus-based gene therapy research
- Genetics and Neurodevelopmental Disorders
- Thyroid Disorders and Treatments
- Heavy Metal Exposure and Toxicity
- Genomics and Rare Diseases
- Diet and metabolism studies
- Virology and Viral Diseases
- Animal Virus Infections Studies
- RNA modifications and cancer
- Respiratory viral infections research
- Congenital heart defects research
- Williams Syndrome Research
- Attention Deficit Hyperactivity Disorder
- Mitochondrial Function and Pathology
- Viral gastroenteritis research and epidemiology
- Child and Adolescent Health
- Infective Endocarditis Diagnosis and Management
- Immunotoxicology and immune responses
- Autism Spectrum Disorder Research
- Genomic variations and chromosomal abnormalities
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Anesthesia and Neurotoxicity Research
- Obesity, Physical Activity, Diet
Children's Hospital of Zhejiang University
2016-2025
Zhejiang University
2007-2024
Ningxia Academy of Agriculture and Forestry Sciences
2024
Children's Hospital
2019
Blood Center of Zhejiang Province
2017
SwissLitho (Switzerland)
2016
Hangzhou Academy of Agricultural Sciences
2016
Boston Children's Hospital
2005-2013
Fuyang Maternity and Child Health Care Hospital
2007
Dyslipidemia in pregnancy are associated with gestational diabetes mellitus (GDM), preeclampsia, preterm birth and other adverse outcomes, which has been extensively studied western countries. However, similar studies have rarely conducted Asian Our study was aimed at investigating the associations between maternal dyslipidemia outcomes among Chinese population.Data were derived from 934 pairs of non-diabetic mothers neonates 2010 2011. Serum blood samples assayed for fasting total...
Although it is widely believed that China facing a major shortage of pediatricians, the real situation current national status pediatric human resources and their working conditions has not been evaluated to date.We administered survey 54 214 hospitals from all 31 provinces in mainland 2015 2016. Hospital directors secondary tertiary with services random sample (10%) primary provided information on number pediatricians educational levels, specialties, workloads, dropout rates, other hospital...
Abstract Background Newborn screening (NBS) has been implemented for neonatal inborn disorders using various technology platforms, but false-positive and false-negative results are still common. In addition, target diseases of NBS limited by suitable biomarkers. Here we sought to assess the feasibility further improving next-generation sequencing technology. Methods We designed a newborn genetic (NBGS) panel based on multiplex PCR next generation analyze 134 genes 74 disorders, that were...
Abstract Background Newborn screening (NBS) is an important and successful public health program that helps improve the long-term clinical outcomes of newborns by providing early diagnosis treatment certain inborn diseases. The development next-generation sequencing (NGS) technology provides new opportunities to expand current newborn methodologies. Methods We designed a genetic (NBGS) panel targeting 135 genes associated with 75 disorders multiplex PCR combined NGS. With this panel,...
Abstract The region on chromosome 7q stands out as the of suggestive linkage to aetiology autism with greatest concordance in many independent genome‐wide scans. RELN and GRM8, two genes selected this study, are located within region. protein products both considered play a pivotal role development central nervous system. In addition, biochemical neuroanatomical data indicated that GRM8 likely involved pathogenesis autistic disorder. Therefore, be not only positional but also functional...
Sepsis is a serious disease with high mortality in newborns. It very important to have convenient and accurate method for pathogenic diagnosis of neonatal sepsis. We developed simultaneous detection Gram classification clinically relevant bacterial pathogens causing sepsis directly from blood samples stain-specific-probe-based real-time PCR (GSPBRT-PCR). With GSPBRT-PCR, 53 strains representing 25 gram-positive 28 gram-negative species were identified correctly the corresponding probe. The...
Background:It is reported that the infant mortality (IM) rate decreased rapidly in China and life expectancy (LE) also had a high increase. Our objective was to determine health status of Chinese population by investigating IM LE their inter-relationship. Material andMethods:Based on literature review history current other major countries, relationship between IM, LE, per capita gross national income (GNI) investigated 2013. Results:The decline from 30% 15% took only 7 years, which faster...
Oncolytic viruses have recently been proven to be an effective and promising cancer therapeutic strategy, but there is rare data about oncolytic therapy in esophageal squamous cell carcinoma (ESCC), especially measles virotherapy. Therefore, this study aimed explore whether the recombinant virus vaccine strain rMV-Hu191 has effect against ESCC cells vitro vivo elucidate underlying mechanisms. Our results showed that could efficiently replicate kill through caspase-3/GSDME-mediated...
The Sulige Gas Field is a typical low-permeability, low-pressure tight gas field, where pneumatic jetting crucial for production. However, existing jet pumps have low efficiency, limiting field production and overall development. This paper explores the effect of adding water, at specific volume fractions, to driving on pump performance. Using Volume Fluid (VOF) Computational Dynamics (CFD) simulations, three-dimensional fluid domain model was developed analyze flow turbulent kinetic energy,...
Introduction The Belt and Road Initiative has increased international student enrollment in China, bringing challenges like diverse preparedness cross-cultural adaptation issues. Effective is essential for students' academic success mental health, yet limited research exists on medical China’s prefectural cities. Objectives This study to examine the levels of cultural stress, psychological resilience, loneliness, coping strategies among students studying clinical centers explore...
Beta-defensin-2 (BD-2), a small cationic antimicrobial peptide, was first described to be an inducible defensin at the epithelial surfaces. In vitro studies have demonstrated that it may play pivotal role in anti-inflammatory immune response addition its activity. The purpose of this study evaluate effect overexpression BD-2 on lung injury crudely investigate whether function attributed both action and modulation response. Recombinant adenovirus carrying expression cassette rat or control...
To investigate effects of developmental lead exposure on nitric oxide synthase (NOS) activity in different brain regions and N-methyl-D-aspartate (NMDA) receptor mRNA expression the hippocampus rats. On basis these observations, we explored possible mechanisms by which leads to impaired learning memorizing abilities children.A series rat animal models exposed low levels during developing period was established (drinking water containing 0.025%, 0.05% 0.075% acetate). NOS activities...
Attention is a complex domain that has reawakened research interest in recent years. There are relatively few studies have examined age-related changes across different attention subcomponents, such as selection, maintenance, and control, using large samples covering wide age range. The present study assessed performance 466 participants order to identify the ages at which mature was reached differing subcomponents. Furthermore, we investigated whether nature of attentional demands or task...
Recent studies have reported that double-stranded RNA (dsRNA) can activate gene expression by targeting promoter sequence in a process termed activation. The present study was conducted to evaluate the potential of WT1 induction small activating (dsWT1) treatment hepatocellular carcinoma.The human carcinoma cell line HepG2 transfected with dsRNA liposomes. mRNA and protein cells were investigated using real-time reverse quantitative PCR Western blot, respectively. Cell viability...