A5048808804- RNA modifications and cancer
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cryospheric studies and observations
- Alzheimer's disease research and treatments
- Protein Degradation and Inhibitors
- Neuroinflammation and Neurodegeneration Mechanisms
- Arctic and Antarctic ice dynamics
- Genomics and Phylogenetic Studies
- Climate change and permafrost
- MicroRNA in disease regulation
- Advanced Nanomaterials in Catalysis
- Dementia and Cognitive Impairment Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Microbial Community Ecology and Physiology
- Acute Myeloid Leukemia Research
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- Concrete and Cement Materials Research
- Parvovirus B19 Infection Studies
- Lymphoma Diagnosis and Treatment
- Nanocluster Synthesis and Applications
Anhui Provincial Children's Hospital
2020-2025
Jiangsu University
2025
Jintan People's Hospital
2025
Hangzhou Dianzi University
2023-2024
Harbin Institute of Technology
2019-2024
Ruijin Hospital
2022-2024
Shanghai Jiao Tong University
2022-2024
Beijing Chao-Yang Hospital
2018-2024
Capital Medical University
2013-2024
Xijing University
2021-2024
There have been no effective treatments for slowing or reversing Alzheimer's disease (AD) until now. Growing preclinical evidence, including this study, suggests that mesenchymal stem cells-secreted exosomes (MSCs-Exos) the potential to cure AD.
// Chao Yang 1,* , Ran Tang Xiang Ma Younan Wang 1 Dakui Luo Zekuan Xu Yi Zhu 1,2 and Li Department of General Surgery, The First Affiliated Hospital Nanjing Medical University, Nanjing, China 2 Jiangsu Province Academy Clinical Medicine, Institute Tumor Biology, * These authors have contributed equally to this work Correspondence to: Yang, email: Keywords : gastric cancer, H19, polymorphism, genotype Received November 17, 2014 Accepted March 19, 2015 Published April 15, Abstract Long...
// Ran Tang 1, * , Chao Yang 2, Xiang Ma Younan Wang 1 Dakui Luo Chi Huang Zekuan Xu Ping Liu 3 Li Department of General Surgery, the First Affiliated Hospital Nanjing Medical University, Nanjing, China 2 Liver Transplantation Center and Key Laboratory on Living Donor Transplantation, Ministry Health, Oncology, These authors have contributed equally to this work Correspondence to: Yang, e-mail: pwkyangli@163.com Keywords: gastric cancer, microRNA-let-7a, PKM2 Received: June 08, 2015...
As the Third Pole of Earth and Water Tower Asia, Tibetan Plateau (TP) nurtures large numbers glacial lakes, which are sensitive to global climate change. These lakes modulate freshwater ecosystem in region but concurrently pose severe threats valley population by means sudden lake outbursts consequent floods (GLOFs). The lack high-resolution multi-temporal inventory TP hampers a better understanding prediction future trend risk lakes. Here, we created using 30-year record 42,833 satellite...
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition of uncontrolled immune activation leading to extreme inflammation. Primary HLH was once believed be disease that occurred only in infancy or young children, and rarely diagnosed adults. It now understood patients can develop primary their adolescence adulthood. This study included 252 adolescent adult with clinical diagnosis from 35 general medical institutions across mainland China. All exons 50 bp flanking intronic...
Abstract Background The relationship between periodontitis and Alzheimer’s disease (AD) has attracted more attention recently, whereas profiles of subgingival microbiomes gingival crevicular fluid (GCF) metabolic signatures in AD patients have rarely been characterized; thus, little evidence exists to support the oral-brain axis hypothesis. Therefore, our study aimed characterize both microbial community plaque metabolomic GCF with amnestic mild cognitive impairment (aMCI) for first time....
The desert is an excellent model for studying evolution under extreme environments. We present here the complete genome and ultraviolet (UV) radiation-induced transcriptome of Deinococcus gobiensis I-0, which was isolated from cold Gobi shows higher tolerance to gamma radiation UV light than all other known microorganisms. Nearly half genes in encode proteins unknown function, suggesting that resistance phenotype may be attributed pathways. D. also contains a surprisingly large number...
The adaptation of fish to low temperatures is the result long-term evolution. Amur carp (Cyprinus carpio haematopterus) survives (0-4°C) for six months per year. Therefore, we chose this as a model organism study mechanisms cold-adaptive responses using high-throughput sequencing technology. This system provided an excellent exploring relationship between evolutionary genomic changes and environmental adaptations. transcriptome was sequenced Illumina platform assembled into 163,121 cDNA...
The rate-distortion optimized quantization (RDOQ) provides significant coding gain in the third generation of Audio Video Standard (AVS3). However, high computational complexity and strong data dependency RDOQ impede hardware implementation. To address these issues, we propose a zig-zag scanline-level parallelized algorithm its fully pipelined architecture for AVS3 video coding. For optimization, update run-level context rate estimation inner scanline an efficient RD cost calculation form...
Abstract Acquired chromosomal DNA copy gains are a feature of many tumors; however, the mechanisms that underpin oncogene amplification poorly understood. Recent studies have begun to uncover importance epigenetic states and histone lysine methyltransferases (KMT) demethylases (KDM) in regulating transient site-specific copy-number (TSSG). In this study, we reveal critical interplay between myriad modulating H3K4/9/27 methylation balance control extrachromosomal EGFR oncogene. This study...
Zn2+ -induced β-amyloid protein (Aβ) aggregation and microglia activation are the predominant contributors in Alzheimer's disease (AD). Regulating intracephalic excessive is a promising therapeutic strategy for AD treatment. However, only inhibition of hardly to repair continuous damages caused by activated microglia. Herein, an intelligent resveratrol-loaded supramolecular vesicles (RES-loaded vesicles) with zinc ion chelation function responsive release capability constructed alleviate Aβ...
The increasing prevalence of Alzheimer's disease and related dementias (ADRD) presents both a burden an opportunity for intervention. This study aims to estimate the impacts health insurance resources on attributed ADRD.
<title>Abstract</title> CRESS-DNA viruses are small, circular, single-stranded DNA that have been identified in diverse environments and hosts, including vertebrates, invertebrates, environmental samples. However, their diversity role the human respiratory tract remain poorly understood. In this study, we employed viral metagenomics to analyze 140 nasopharyngeal swab samples from asymptomatic individuals. High-throughput sequencing bioinformatics analyses were used identify characterize...