A5013507808- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Advancements in Transdermal Drug Delivery
- Analytical Methods in Pharmaceuticals
- Essential Oils and Antimicrobial Activity
- Pharmacological Effects of Natural Compounds
- Inflammatory mediators and NSAID effects
- Analytical Chemistry and Chromatography
- Education and Critical Thinking Development
- Berberine and alkaloids research
- Plant Growth Enhancement Techniques
- Educational Assessment and Pedagogy
- Cancer, Lipids, and Metabolism
- Silicon Effects in Agriculture
- Advanced Sensor and Energy Harvesting Materials
- Crystallization and Solubility Studies
- Plant and soil sciences
- Wound Healing and Treatments
- Sulfur Compounds in Biology
- Pharmaceutical studies and practices
- E-Learning and COVID-19
- Biological Activity of Diterpenoids and Biflavonoids
Quaid-i-Azam University
2025
Islamia University of Bahawalpur
2013-2024
Harbin Institute of Technology
2018-2023
Albany Medical Center Hospital
2023
Government College University, Lahore
2023
Northern University of Malaysia
2023
University of Lahore
2020-2021
King's College London
2018-2020
Hamdard University
2020
Transnational Press London
2020
Chronic wounds have become a significant threat to people's physical and mental health increased the burden of social medical care. Intelligent wound dressing (IWD) with condition monitoring closed-loop on-demand drug therapy can shorten healing process alleviate patient suffering. However, single-function dressings cannot meet current needs chronic treatment. Here, wearable IWD consisting exudate management, sensor monitoring, therapy, flexible circuit modules is reported, which achieve...
Synergistic cancer starvation/ROS-mediated/chemo-therapy is developed through a cascade reaction with enzyme glucose oxidase (GOX) modified on the surface of an Fe-based metal organic framework (MOF(Fe)) and drug camptothecin (CPT) loaded into cavities MOF(Fe). Once internalized by tumor cells, GOX catalyzes endogenous hydrogen peroxide (H2O2) gluconic acid (H+) enabling starvation therapy choking off energy (glucose) supply. Meanwhile, acidic micro-environment enhanced generated H+ degrades...
Methicillin-resistant Staphylococcus aureus (MRSA) is a clinically prevalent bacterium and resistant to many drugs. Genetic factors such as mec genes are considered be responsible for this resistance. Recently, Staphylococcal Cassette Chromosome (SCCmec) element mutations produced mecC, new genetic variant that encodes transpeptidase enzyme (63% similarity with mecA-encoded PBP2a). This cross-sectional study was conducted establish the prevalence of mecA mecC among phenotypically identified...
Calcium carbonate (CaCO3), a natural common inorganic material with good biocompatibility, low toxicity, pH sensitivity, and cost, has widespread use in the pharmaceutical chemical industries. In recent years, an increasing number of CaCO3-based nano-drug delivery systems have been developed. CaCO3 as drug carrier utilization efficient Ca2+ CO2 donor played critical role tumor diagnosis treatment explored depth breadth. Starting from system, this paper systematically reviews preparation...
Exploiting zeolitic imidazolate framework (ZIF)-based nanoparticles to synergistically enhance starvation-combined chemotherapy strategies remains an urgent demand. Herein, glucose oxidase (GOX) and doxorubicin (DOX) were facilely incorporated into ZIFs for chemotherapy. The as-prepared DOX/GOX-loaded ZIF (DGZ) exhibited uniform size with good dispersity, effective protection of the GOX activity, stable delivery drugs tumor. Correspondingly, it could achieve glucose- pH-responsive...
An ultralow-intensity (0.30 W cm<sup>−2</sup>) near-infrared light-triggered PDT was developed and enhanced through combination of GSH-depletion chemotherapy based on both exo- endogenous synergistic effects.
A novel scheme to perform the fusion of multiple images using multivariate empirical mode decomposition (MEMD) algorithm is proposed. Standard multi-scale techniques make a priori assumptions regarding input data, whereas standard univariate (EMD)-based suffer from inherent mixing and misalignment issues, characterized respectively by either single intrinsic function (IMF) containing scales or same indexed IMFs corresponding carrying different frequency information. We show that MEMD...
Abstract H 2 S‐mediated tumor therapy has received great attention due to its unique physiological activity and synergistical enhancement, but suffers from limited S donors with promised biosafety regulate the delivery subsequently elusive pathway augment combined therapy. Herein, a PEGylated porous molybdenum disulfide nanoflower (MSP) abundant defects is facilely synthesized for tumor‐targeted theranostics. MSP possesses good water‐dispersity high photothermal ability, which used...
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United Nations Sustainable Development Goal 7 is about ensuring access to clean and affordable energy, which a key factor in the development of society. The power generation sector majorly consists thermal plants. Cooling towers are significant part any plant cool steam be reused again. Hence, efficiency plants can increased by optimizing performance cooling towers. This research paper aims increase investigating effect ambient parameters (changing with climate) on for best site selection....
Background: Maize (Zea mays L.), a globally important cereal crop, faces significant yield constraints due to increasing environmental stressors such as drought, heat, salinity, and soil nutrient deficiencies. Climate change declining fertility continue jeopardize food security in many maize-growing regions. Understanding the physiological morphological responses of maize these abiotic stress factors is crucial for developing climate-resilient cultivars optimizing agronomic practices...
Reasoning has become an essential tool for all students to cope with challenges of the modern world. Therefore, foster reasoning among students, teachers should use effective strategies in teaching process. The present experimental study aims assess effect metacognitive mathematical female students. Pre-test post-test control group design was adopted study. participants were 44 students: 21 and 23 group. A valid reliable research instrument; test pretest a posttest conducted before after...
Background: Sleep disturbances, including insomnia and obstructive sleep apnea (OSA), have been increasingly linked to cardiovascular diseases. However, their relationship with stroke risk remains controversial. While some studies suggest a strong association, others show limited or no correlation. This meta-analysis synthesizes observational data assess the association between disorders risk, aiming provide clearer insights into this critical public health concern. Methods: A systematic...
Systemic mirtazapine (MRT) delivery for the treatment of pruritis exhibits severe side effects which needs to be addressed. For this purpose, topical nanostructured lipid carriers (NLCs) containing MRT were developed minimize and enhance therapeutic efficacy. The microemulsion method was utilized preparation loaded NLCs final optimized formulation in gel effective application. terms particle size (PS), zeta potential (ZP), polydispersity index (PDI), percentage entrapment efficiency (% EE)...
Green synthesis of mPEG–PLGA and nanoformulation for delivery irinotecan to colon cancer.
The study aimed to fabricate and evaluate Meloxicam (MLX) loaded Hydroxypropyl Methylcellulose (HPMC) microparticles for colon targeting because MLX is a potent analgesic used in the treatment of pain inflammation associated with colorectal cancer (CRC). Nevertheless, its efficiency limited by poor solubility gastrointestinal tracts (GIT) side effects. Seventeen formulations HPMC were fabricated oil-in-oil (O/O)/ emulsion solvent evaporation (ESE) technique. A 3-factor, 3-level Box Behnken...
PURPOSE: The purpose of this study was to investigate the ability a self-nano-emulsifying drug delivery system (SNEDDS) enhance oral bioavailability BCS class IV drug, etoposide (VP-16). METHOD: A series SNEDDS formulations with VP-16 were prepared consisting medium chain triglycerides, polysorbate 80, diethylene glycol monoethyl ether and propylene monolaurate type-1. Based on an obtained ternary phase diagram, optimum formulation selected characterized in terms size, zeta potential,...
Epalrestat (EPL) is a carboxylic acid derivative with poor aqueous solubility and its pharmacokinetic features are not fully defined.Current research aimed to fabricate inclusion complexation of EPL SBE7 β-CD (IC) EPL/SBE7 CS NPs (NP).EPL was complexed using the co-precipitation method, prepared complex fabricated into nanoparticles ionic gelation method. The formulations were characterized for particle size analysis, surface morphology, in vitro dissolution study. % inhibition against...