A5054063155- Circular RNAs in diseases
- Mesenchymal stem cell research
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Animal Virus Infections Studies
Jiangsu University
2020-2025
Jintan People's Hospital
2020-2025
Affiliated Hospital of Jiangsu University
2025
As an alternative mesenchymal stem cell- (MSC-) based therapy, MSC-derived extracellular vesicles (EVs) have shown promise in the field of regenerative medicine. We previously found that human umbilical cord cell-derived EVs (hUCMSC-EVs) improved functional recovery and nerve regeneration a rat model sciatic transection. However, underlying mechanisms are poorly understood. Here, we demonstrated for first time hUCMSC-EVs promoted proliferation Schwann cells by activating PI3K/AKT signaling...
<title>Abstract</title> CRESS-DNA viruses are small, circular, single-stranded DNA that have been identified in diverse environments and hosts, including vertebrates, invertebrates, environmental samples. However, their diversity role the human respiratory tract remain poorly understood. In this study, we employed viral metagenomics to analyze 140 nasopharyngeal swab samples from asymptomatic individuals. High-throughput sequencing bioinformatics analyses were used identify characterize...
Peripheral nerve injury and regeneration are complex processes involve multiple molecular signalling components. However, the involvement of long non-coding RNA (lncRNA) in this process is not fully clarified. In study, we evaluated expression lncRNA maternally expressed gene 3 (MEG3) rats after sciatic transection explored its potential mechanisms. The MEG3 was up-regulated following observed Schwann cells (SCs). down-regulation SCs enhanced proliferation migration via PTEN/PI3K/AKT...