A5081013892- Neuroinflammation and Neurodegeneration Mechanisms
- Multiple Sclerosis Research Studies
- Extracellular vesicles in disease
- Carbon and Quantum Dots Applications
- Erythropoietin and Anemia Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- Liver Disease Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Adsorption and biosorption for pollutant removal
- Alzheimer's disease research and treatments
- Nanomaterials for catalytic reactions
- Cholinesterase and Neurodegenerative Diseases
- Stroke Rehabilitation and Recovery
- Thyroid and Parathyroid Surgery
- Botulinum Toxin and Related Neurological Disorders
- Neurogenesis and neuroplasticity mechanisms
- Peripheral Neuropathies and Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Uterine Myomas and Treatments
- Proteoglycans and glycosaminoglycans research
- PARP inhibition in cancer therapy
- Breast Lesions and Carcinomas
- Cardiomyopathy and Myosin Studies
Jingzhou Central Hospital
2025
Anyang Hospital of Traditional Chinese Medicine
2014-2024
Weifang Medical University
2023-2024
Huazhong University of Science and Technology
2018-2024
Union Hospital
2023-2024
Union Hospital
2024
Second Hospital of Shandong University
2024
Huazhong Agricultural University
2022-2023
Ministry of Agriculture and Rural Affairs
2023
Xiamen University of Technology
2023
Rho kinase (ROCK) may play an important role in regulating biological events of cells, including proliferation, differentiation and survival/death. Blockade ROCK promotes axonal regeneration neuron survival vivo vitro, thereby exhibiting potential clinical applications spinal cord damage stroke. Our previous studies have demonstrated that Fasudil, a selective inhibitor, induced neuroprotection vitro. Here we used model hypoxia/reoxygenation (H/R) injury to examine the neuroprotective effect...
Vinpocetine has long been used for cerebrovascular disorders and cognitive impairment. Based on the evidence that translocator protein (TSPO, 18 kDa) was expressed in activated microglia, while able to bind TSPO, we explored role of microglia treated with lipopolysaccharide (LPS) oxygen–glucose deprivation (OGD) vitro . Our results show both LPS OGD induced up-regulation TSPO expression BV-2 by RT-PCR, western blot immunocytochemistry. inhibited production nitrite oxide inflammatory factors...
Hierarchically porous melamine-formaldehyde resin microspheres (MFRM) with mesopores/macrospores (10–90 nm) and flow-through pores (∼1000 were first prepared by sacrificing template approach. MFRM had satisfactory theoretically maximum adsorption capacity based on Langmuir model for gold (179.2 mg g–1) silver (132.5 nanoparticles (AuNPs AgNPs), which one kind of high concern emerging environmental contaminants. Based molecular docking study, the interaction mechanism was ascribed as...
To evaluate the clinical efficacy of ultrasound-guided percutaneous microwave ablation (PMWA) therapy for symptomatic uterine fibroids in a multicentre study.Patients with who underwent PMWA at multiple treatment centres China between January 2013 and August 2015 were prospectively studied to compare reduction rate fibroids, haemoglobin level fibroid symptom health-related quality life questionnaire (UFS-QOL) scores before 3, 6 12 months after ablation.A total 311 patients (405 leiomyomas)...
Recognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy. We aimed to identify factors that predicted among AQP4-ab-positive NMOSD, develop outcome prediction models, and validate them a multicenter validation cohort.Between January 2015 December 2020, 820 NMOSD were registered at Huashan Hospital. retrospectively reviewed their medical...
<p indent="0mm">20(S)-Ginsenoside Rh2 has significant anti-tumor effects in various types of cancers, including human hepatocellular carcinoma (HCC). However, its molecular targets and mechanisms action remain largely unknown. Here, we aim to elucidate the potential by which suppresses HCC growth. We first demonstrate role inhibiting angiogenesis. observe that effectively cell proliferation induces apoptosis HUVECs. Furthermore, significantly inhibits HepG2-stimulated HUVEC proliferation,...
Although microwave ablation (MWA) is a promising technique for hepatocellular carcinoma (HCC) treatment, its 10-year efficacy unknown.The objective of the study was to assess whether advances in MWA HCC translated into real-world survival benefit.This retrospective included 2,354 patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 B from 5 hospitals, at least 2 years follow-up all patients. Recurrence and were analyzed using Kaplan-Meier method time-period stratification.A total 5,326...
Abstract Background and purpose Data regarding the efficacy safety of currently widely available preventive therapies in neuromyelitis optica spectrum disorder (NMOSD) are needed. We compared azathioprine (AZA), mycophenolate mofetil (MMF), reduced dose rituximab (RTX) NMOSD based on a large multicenter retrospective cohort. Methods Patients with aquaporin 4 (AQP4) antibody‐positive AZA ( n = 167), MMF 131), or RTX 55) as initial treatment were included. The main outcome was occurrence...
Neuroserpin (NSP) reportedly exerts neuroprotective effects in cerebral ischemic animal models and patients; however, the mechanism of protection is poorly understood. We thus attempted to confirm NSP on astrocytes state then explored relative mechanisms. Astrocytes from neonatal rats were treated with oxygen-glucose deprivation (OGD) followed by reoxygenation (OGD/R). To NSP, we measured cell survival rate, lactate dehydrogenase (LDH) release; also performed morphological methods, namely...