A5082924224- Ultrasound and Hyperthermia Applications
- Nanoplatforms for cancer theranostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Photoacoustic and Ultrasonic Imaging
- Thyroid Cancer Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Ultrasound Imaging and Elastography
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Ultrasound and Cavitation Phenomena
- Nanoparticle-Based Drug Delivery
- Radiomics and Machine Learning in Medical Imaging
- Thyroid and Parathyroid Surgery
- S100 Proteins and Annexins
- Stress Responses and Cortisol
- MicroRNA in disease regulation
- Photodynamic Therapy Research Studies
- Cancer-related molecular mechanisms research
- MRI in cancer diagnosis
- Head and Neck Anomalies
- Veterinary Medicine and Surgery
- Ovarian cancer diagnosis and treatment
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
Harbin Medical University
2016-2025
Third Affiliated Hospital of Harbin Medical University
2016-2025
Zhongshan Hospital
2024
Tongren Hospital
2024
Tianjin Third Central Hospital
2024
Chinese PLA General Hospital
2024
Tianjin Medical University
2024
Huashan Hospital
2024
Shanghai Jiao Tong University
2024
Fudan University
2024
The aim of this study was to investigate the therapeutic efficacy percutaneous radiofrequency (RF) ablation versus microwave (MW) for hepatocellular carcinoma (HCC) measuring ≤ 5 cm in greatest diameter. From January 2006 December 2006, 78 patients had undergone RF whereas 77 MW ablation. Complete (CA), local tumour progression (LTP) and distant recurrence (DR) were compared. overall survival curves calculated with Kaplan-Meier technique compared log-rank test. CA rate 83.4% (78/93)...
The diagnosis performance of B-mode ultrasound (US) for focal liver lesions (FLLs) is relatively limited. We aimed to develop a deep convolutional neural network US (DCNN-US) aiding radiologists in classification malignant from benign FLLs.This study was conducted 13 hospitals and finally 2143 patients with 24,343 images were enrolled. Patients who had non-cystic FLLs pathological results 11 randomly divided into training internal validations (IV) cohorts 4:1 ratio developing evaluating...
Background: Breast ultrasound is the first choice for breast tumor diagnosis in China, but Imaging Reporting and Data System (BI-RADS) categorization routinely used clinic often leads to unnecessary biopsy. Radiologists have no ability predict molecular subtypes with important pathological information that can guide clinical treatment. Materials Methods: This retrospective study collected images from two hospitals formed training, test external sets after strict selection, which included...
Background: The combination of sonodynamic therapy and oxygenation strategy is widely used in cancer treatment. However, due to the complexity, heterogeneity irreversible hypoxic environment produced by hepatocellular carcinoma (HCC) tissues, oxygen-enhancing (SDT) has failed achieve desired results. With emergence ferroptosis with reactive oxygen species (ROS) cytotoxicity, this novel cell death method attracted widespread attention. Methods: In study, nanobubbles (NBs) were connected...
Objectives Neoadjuvant chemotherapy plays an important role in comprehensive therapy for breast cancer, but response prediction is imperfect. Shear wave elastography (SWE) a novel technique that can quantitatively evaluate tissue stiffness. In this study, we sought to investigate the application value of SWE early neoadjuvant patients with cancer. Methods We prospectively evaluated tumor stiffness 62 cancer using SWE, which was performed at baseline and after second cycle chemotherapy. After...
Abstract The immunosuppressive tumor microenvironment (TME) has become a major challenge in cancer immunotherapy, with abundant tumor-associated macrophages (TAMs) playing key role promoting immune escape by displaying an (M2) phenotype. Recently, it was reported that M1 macrophage-derived nanovesicles (M1NVs) can reprogram TAMs to anti-tumor phenotype, thereby significantly alleviating the TME and enhancing efficacy of immunotherapy. Herein, we developed M1NVs loaded mesoporous dopamine...
To retrospectively evaluate the diagnostic performance of shear wave elastography (SWE) and thyroid imaging reporting data system (TI-RADS) in differentiating malignant benign nodules. A total 313 nodules 227 patients were included. All underwent SWE TI-RADS before fine needle aspiration biopsy and/or surgery. elasticity indices maximum (Emax), mean (Emean), minimum (Emin) elastic ratio (ER) measured. Nodules with solid component, marked hypoechogenicity, poorly defined margins,...
The drug resistance of triple negative breast cancer (TNBC) is considered as a major obstacle for the curative effect chemotherapy. Long intergenic noncoding RNA 00511 (LINC00511) has been target gene resistance. A novel theranostic agent loaded with LINC00511-siRNA to deliver siRNA was structured, and responses sensitivity in TNBC were detected. Next-generation high-throughput sequencing (RNA-Seq) performed accurately analyze differential expression mRNAs lncRNA targets after transfection...
Abstract In this study we examined whether l -arginine treatment could prevent corticotropin (ACTH)–induced increases in blood pressure the Sprague-Dawley rat. Sixty rats were randomly divided into six groups (n=10): sham injection, ACTH injection (0.5 mg/kg per day doses), (0.6%) food plus treatment, d and ACTH. Systolic pressure, water intake, urine volume, body weight, plasma urinary electrolytes, serum corticosterone concentrations measured. increased systolic (from 127±2 to 165±6 mm Hg,...
The use of SonoVue combined with ultrasound exposure increases the transfection efficiency short interfering RNA (siRNA). objective this study was to prepare targeted nanobubbles (TNB) conjugated NET-1 siRNA and an antibody GPC3 direct hepatocellular carcinoma cells. SMMC-7721 human cells were treated six different groups. cellular apoptosis measured by flow cytometry. protein messenger (mRNA) expression Western blot quantitative real-time PCR, respectively. migration invasion potential...
Although microwave ablation (MWA) is a promising technique for hepatocellular carcinoma (HCC) treatment, its 10-year efficacy unknown.The objective of the study was to assess whether advances in MWA HCC translated into real-world survival benefit.This retrospective included 2,354 patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 B from 5 hospitals, at least 2 years follow-up all patients. Recurrence and were analyzed using Kaplan-Meier method time-period stratification.A total 5,326...
Abstract Background Automated breast ultrasound (ABUS) is a useful choice in disease diagnosis. The axillary lymph node (ALN) status crucial for predicting the clinical classification and deciding on treatment of early-stage cancer (EBC) could be primary indicator locoregional recurrence. We aimed to establish prediction model using ABUS features predict ALN status. Methods A total 469 lesions were divided into metastasis (ALNM) group no ALNM (NALNM) group. Univariate analysis multivariate...
Apoptosis resistance of hepatocellular carcinoma (HCC) often leads to treatment failure. Nonetheless, overcoming the HCC apoptosis by inducing necroptosis tumor cells bypass apoptotic pathway may be a promising strategy. Sonodynamic therapy (SDT) has broad prospects in disease because its noninvasive characteristic and spatiotemporal control. The combination SDT shikonin is expected new method that can overcome resistance.In this study, antitumor effect was evaluated using normal liver cell...
Background Noninvasive evaluation of metabolic dysfunction-associated fatty liver disease (MAFLD) with multiparametric US is essential, but multicenter studies are lacking. Purpose To evaluate the ability attenuation imaging (ATI) and two-dimensional (2D) shear-wave elastography (SWE) for predicting steatohepatitis (MASH) in participants MAFLD, regardless hepatitis B virus infection status. Materials Methods This prospective cross-sectional study consecutive adults MAFLD who underwent ATI 2D...
Hepatocellular carcinoma (HCC) is the most common primary malignant disease of liver. Although immunotherapy offers new opportunities for treating advanced HCC, its therapeutic effect still limited by immunosuppressive tumor microenvironment (TME). Herein, a nanosensitizer RGD@Ce6@MSA-2@Liposome (RCM-Lip) synthesized to specifically initiate HCC immune through sonodynamic therapy (SDT)-triggered immunogenic cell death (ICD) and MSA-2-activated cyclic GMP-AMP synthase (cGAS)-stimulator...
The present study investigated enhancement of apoptosis induction and the mechanisms underlying calcium overload on C6 glioma cells in vitro, stimulated by low-level ultrasound combination with hematoporphyrin monomethyl ether (HMME). optimum frequency was determined 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. apoptotic rate, reactive oxygen species concentration decreased mitochondrial membrane potential (MMP) were analyzed flow cytometry. Morphological changes...