A5100710382- Traditional Chinese Medicine Studies
- Medical Research and Treatments
- Pain Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Lung Cancer Research Studies
- Acupuncture Treatment Research Studies
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Ion Channels and Receptors
- Ion channel regulation and function
- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Esophageal and GI Pathology
- Neuroscience and Neuropharmacology Research
- Pediatric Urology and Nephrology Studies
- Pharmaceutical studies and practices
- Health and Well-being Studies
- Kidney Stones and Urolithiasis Treatments
- Sirtuins and Resveratrol in Medicine
- Frailty in Older Adults
- Resilience and Mental Health
- Cancer Immunotherapy and Biomarkers
- Genital Health and Disease
- Nitric Oxide and Endothelin Effects
- Nursing education and management
Capital Medical University
2008-2025
Sichuan Cancer Hospital
2018-2024
University of Electronic Science and Technology of China
2018-2024
Nanjing University of Chinese Medicine
2024
Jiangsu University
2024
Jilin Agricultural University
2020-2023
National Engineering Research Center for Wheat
2020-2023
Ningbo University
2014-2023
Ningbo First Hospital
2014-2023
Shanghai Jiao Tong University
2023
Calcium/calmodulin-dependent protein kinase II (CaMK II) is found throughout the CNS. It regulates calcium signaling in synaptic transmission by phosphorylating various proteins, including neuronal membrane receptors and intracellular transcription factors. Inflammation or injuries to peripheral tissues cause long-lasting increases responses of central nociceptive neurons innocuous noxious stimuli. This change can occur independently alterations responsiveness primary afferent has been...
Epidemiologic studies on mild cognitive impairment (MCI) are limited in China.Using a multistage cluster sampling design, total of 10,276 community residents (6096 urban, 4180 rural) aged 65 years or older were evaluated and diagnosed with normal cognition, MCI, dementia. MCI was further categorized by imaging into caused prodromal Alzheimer's disease (MCI-A), resulting from cerebrovascular (MCI-CVD), vascular risk factors (MCI-VRF), other diseases (MCI-O).The prevalences overall MCI-A,...
Autophagy flux plays a significant protective role in type 2 diabetes mellitus (T2DM). However, the mechanisms by which autophagy mediates insulin resistance (IR) to ameliorate T2DM remain unclear. This study explored hypoglycemic effects and of walnut-derived peptides (fraction 3-10 kDa LP5) streptozotocin high-fat-diet-induced mice. Findings revealed that reduced levels blood glucose FINS ameliorated IR dyslipidemia. They also increased SOD GSH-PX activities inhibited secretion TNF-α,...
Oxidative stress is an important factor in the pathogenesis of insulin resistance (IR) type 2 diabetes mellitus (T2DM). Bioactive peptides from nuts have been shown to alleviate oxidative and IR. However, specific mechanisms underlying their activity remain unclear. This study investigated protective effects three novel derived Juglans mandshurica Maxim., LVRL, LRYL, VLLALVLLR, against high glucose-induced IR HepG2 cells. The possible these were also elucidated. walnut-derived improved...
Background: Acute cutaneous neurogenic inflammation initiated by activation of transient receptor potential vanilloid-1 (TRPV 1 ) receptors following intradermal injection capsaicin is mediated mainly dorsal root reflexes (DRRs). Inflammatory neuropeptides are suggested to be released from primary afferent nociceptors participating in inflammation. However, no direct evidence demonstrates that the release inflammatory substances due triggering DRRs and how TRPV initiates via DRRs. Results:...
Caregivers of care-recipients with mild cognitive impairment (MCI) or dementia experience high caregiver burden; however, the psychiatric burden caregivers subjective decline (SCD) has not been investigated. We aimed to explore prevalence and risk factors for anxiety depression symptoms among SCD impairment. The Hospital Anxiety Depression Scale (HADS) was used examine 343 (84 SCD, 120 MCI 139 dementia) treated at Memory Clinic Huashan in Shanghai, China from May 2012 October 2014. A...
To propose the suitable diameter of calculus debris produced during flexible ureteroscopy lithotripsy (fURL). A glass tube was used to simulate stone excretion process Furl. Different diameters (0.50-1.00 mm, 0.25-0.50 and 0.10-0.25 mm) with three sizes (fURS) (7.5Fr, 8.7Fr, 9.9Fr) ureteral access sheath (UAS) (12/14Fr) or without negative pressure suction were employed in experiment. The intraoperative calculi (ICE) recorded according stones discharged from gap between fURS UAS. ICE raised...
Abstract Background A mobile cognition scale for community screening in cognitive impairment with rigorous validation is paucity. We aimed to develop a digital that overcame low education mild (MCI) due Alzheimer’s disease (AD) and AD. Methods self-assessment (CogSAS) was designed through the Delphi process, which feasible older population education. In Phase 1, 518 clinically diagnosed participants were subjected optimise items. 2, validated 358 cognitively unimpaired 396 of MCI dementia...
Neuropathic and inflammatory pain can be modulated by the sympathetic nervous system. In some models, postganglionic efferents are involved in modulation of nociceptive transmission periphery. The purpose this study is to examine sensitization Adelta- C-primary afferent nociceptors induced intradermal injection capsaicin (CAP) see whether presence essential for sensitization. Single primary discharges were recorded from tibial nerve after fiber types identified conduction velocity...
This retrospective analysis evaluated the mechanism of bevacizumab plus chemotherapy (BV+CT) for preventing brain metastasis derived from lung cancer. From total 159 patients with advanced non-small cell cancer (NSCLC), 110 received BV+CT and 49 CT. After medication, both groups had 15 metastases (14 vs 31%, P < 0.05). With treatment, 40 (33.89%) survived, whereas only 11 (18.64%) survived CT treatment. The outcome group was significantly better than that vascular endothelial growth factor...
Objectives: Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and common form of dementia in older people. Some types mild cognitive impairment (MCI) are clinical precursors AD, while other MCI forms tend to remain stable over time do not progress AD. To discriminate patients at risk AD from MCI, we propose a novel deep-learning radiomics (DLR) model based on 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) images combine DLR features with parameters...
Recently, we showed that supplementation with nitric oxide (NO) via donor nitroglycerin (NG) alleviated the ovariectomy and corticosteroid-induced bone loss in rats. In humans, high doses or frequent applications of NG (i.e., for angina) lead to rapid its efficacy relieving angina. To examine whether there is a similar effect on bone, examined frequency-dependent effects mineral density (BMD), mass, trabecular volumes (BV/TV), blood pressure Thirty 7-month-old female Brown Norway rats...
Background: Surgical resection is one of curative treatment for gastric cancer (GC), however, a set patients show poor surgical compliance in the USA. We aimed to identify risk factors associated with and investigate difference survival. Methods: GC diagnosed between 1973 2014 were identified from Surveillance Epidemiology End Results (SEER) databases. Based on different regimen, classified into three subgroups: group, noncompliance non-surgical group. Multivariable Logistic regression...
A series of experiments by our group suggest that the initiation and development neurogenic inflammation in rats are mainly mediated dorsal root reflexes (DRRs), which conducted centrifugally from spinal horn primary afferent nocieptors. In this study, DRRs were recorded anesthetized single fibers proximal ends cut filaments at L4-L6 level tested for responses to intradermal injection capsaicin. Sympathectomy combined with pharmacological manipulations employed determine if capsaicin-evoked...
Traditional Chinese Medicine (TCM), as a complex medical science which reflects philosophical principles and embodies large dialectical thought, is used to place the human body into system for observation. Acupuncture vital part of TCM, has been practiced treat various diseases symptoms. However, acupuncture also facing severe challenges resulted from insufficient modern scientific research. Nowadays, holistic effects can be researched by some approaches, such systems biology fMRI technique....
The purpose of this study is to compare the efficacy and safety concurrent chemoradiotherapy (CCRT) versus chemotherapy alone for patients with stage IV esophageal squamous cell carcinoma (ESCC). Eligible were retrospectively enrolled at authors's institution from January 2010 October 2015. Of 141 enrolled, 55 (39.0%) received CCRT 86 (61.0%) alone. outcomes adverse events (AEs) compared between two groups. baseline clinical characteristics groups similar. However, group showed a...
Background: Strong noxious stimuli cause plastic changes in spinal nociceptive neurons. Intracellular signal transduction pathways from cellular membrane to nucleus, which may further regulate gene expression by critical transcription factors, convey peripheral stimulation. Cyclic AMP-responsive element binding protein (CREB) is a well-characterized stimulus-induced factor whose activation requires phosphorylation of the Serine-133 residue. Phospho-CREB can induce and strengthen synaptic...
Background and objective: Teaching is widely recognized as a highly stressful profession. Job stress leads to emotional exhaustion, which in turn triggers teacher attrition. The cost estimated USD 2.2 billion annually for dropouts. It therefore important understand the mental state of teachers factors that may influence it order provide appropriate early intervention. In past, more attention has been paid status economically developed cities, but less research conducted remote cities. this...
The dysregulation of TGF- β /Smads signaling pathway has been postulated to contribute the development ulcerative colitis (UC) and manifestation clinical symptoms. Kuijie Granule is a prescription medicine used clinically in China alleviate symptoms associated with UC. To evaluate whether benefit signaling, we measured expression levels proteins (TGF- 1, RII, Smad2, Smad4, Smad6, Smad7) intestinal mucosa 72 patients UC treated for 60 days. Colonic tissues were obtained by virtual colonoscopy...
The contribution of nitric oxide to host resistance experimental pyelonephritis is not well understood. We examined whether the inhibition synthesis alters sensitivity lipopolysaccharide (LPS) responder (C3H/HeN) and nonresponder (C3H/HeJ) mice Escherichia coli pyelonephritis. C3H/HeJ C3H/HeN were implanted subcutaneously with minipumps containing an inhibitor oxide, NG-nitro-L-arginine methyl ester (L-NAME), or a corresponding vehicle. Ascending urinary tract infection by bladder...
Background The oesophageal carcinoma patients show high incidence of malnutrition, which negatively affects their therapy outcome. Moreover, benefits enteral nutrition remain to be studied in details these patients. Therefore, we set assess the effects on nutritional status, treatment toxicities and survival treated with concurrent chemoradiotherapy (CCRT). Materials Methods Eligible were randomly assigned either experimental or control group. group a whole-course management, while provided...
To investigate the correlation between ultrasound performance and prognostic factors in malignant non-mass breast lesions (NMLs).