A5054594266- Amyloidosis: Diagnosis, Treatment, Outcomes
- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Cancer-related molecular mechanisms research
- Chronic Lymphocytic Leukemia Research
- Medical Imaging and Analysis
- Peptidase Inhibition and Analysis
- Breast Cancer Treatment Studies
- Multiple Myeloma Research and Treatments
- Renal Diseases and Glomerulopathies
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Alzheimer's disease research and treatments
- Monoclonal and Polyclonal Antibodies Research
- Renal and related cancers
- Cancer Research and Treatments
- Infant Development and Preterm Care
- Hepatocellular Carcinoma Treatment and Prognosis
- Reproductive System and Pregnancy
- Liver Disease and Transplantation
- Nanoparticle-Based Drug Delivery
Anhui Medical University
2016-2025
First Affiliated Hospital of Anhui Medical University
2021-2025
Affiliated Hospital of Southwest Medical University
2017-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Shandong University
2015-2025
Qingdao University
2025
Affiliated Hospital of Qingdao University
2025
Hainan Medical University
2019-2025
Southwest Medical University
2011-2025
Nanchang Institute of Technology
2025
Purpose We evaluated predictors of prostate cancer–specific mortality (PCSM) after prostate-specific antigen (PSA) failure radical prostatectomy (RP) or radiation therapy (RT). Patients and Methods A total 1,159 men with clinically localized cancer treated RP (n = 498) RT 661) developed PSA failure, they formed the study cohort. Competing risk regression analyses were used to evaluate whether previously identified time metastasis, including post-treatment doubling (PSA-DT), Gleason score,...
Intrapartum antibiotic prophylaxis reduces the risk of infection to a mother and neonate, but antibiotic-mediated maternal neonatal microbiota dysbiosis increases other health risks newborn infants. We studied impact perinatal on in mothers newborns with full-term or preterm delivery. Ninety-eight pregnant women their neonates were divided into following four groups: full term without exposure (FT), (FTA), (PT), (PTA). Bacterial composition was analyzed by sequencing 16S rRNA gene from...
Targeting androgen receptor (AR) has been shown to be promising in treating glioblastoma (GBM) cell culture and flank implant models but the mechanisms remain unclear. AR antagonists including enzalutamide are available for prostate cancer patients clinic can pass blood–brain barrier, thus potentially good candidates GBM treatment have not tested orthotopically. Our current studies confirmed that patients, a majority of tumors overexpress both genders. Enzalutamide inhibited proliferation...
Micro/nanoparticles-based drug delivery system has emerged significantly and influenced the pharma industry up to considerable extent. At same time, development of production methods that are cost effective, scalable reproducible becomes crucial ensure clinical translation any development. The application electrospray (ES) technology in micro-nano not only above advantages, but also can quickly obtain uniform stable micro/nanoparticles as carriers through its own characteristics. Natural or...
Renal fibrosis is the common histopathological feature of chronic kidney diseases (CKD), and there increasing evidence that epigenetic regulation involved in occurrence progression renal fibrosis. N-myc downstream-regulated gene 2 (NDRG2) significantly down-regulated fibrosis, mechanism which remains unclear. Previous studies have confirmed inhibition NDRG2 expression tumor cells related to hyper-methylation, mainly regulated by DNA methyltransferases (DNMTS). Herein, we explored its...
Abstract Aging exhibits several hallmarks in common with cancer, such as cellular senescence, dysbiosis, inflammation, genomic instability, and epigenetic changes. In recent decades, research into the role of senescence on tumor progression has received widespread attention. While how limits course cancer is well established, also been found to promote certain malignant phenotypes. The tumor‐promoting effect mainly elicited by a senescence‐associated secretory phenotype, which facilitates...
This review explores the mechanisms of chronic radiation-induced skin injury fibrosis, focusing on transition from acute radiation damage to a fibrotic state. It reviewed cellular and molecular responses radiation, highlighting role myofibroblasts significant impact Transforming Growth Factor-beta (TGF-β) in promoting fibroblast-to-myofibroblast transformation. The delves into epigenetic regulation gene expression, contribution extracellular matrix proteins microenvironment, immune system...
Objective The objective of this study is to develop a model predicts the postoperative Hunt-Hess grade in patients with intracranial aneurysms by integrating radiomics and deep learning technologies, using preoperative CTA imaging data. Thereby assisting clinical decision-making improving assessment prognosis neurological function. Methods This retrospective encompassed 101 who underwent aneurysm embolization surgery. 851 radiomic features were extracted from images. 512 are last layer...
Abstract Background Heart failure (HF) remains a significant public health challenge globally. This study aims to systematically analyze the global HF disease burden from 1990 2021 across temporal, spatial, and demographic dimensions provide evidence for targeted prevention control strategies. Methods Using data Global Burden of Disease (GBD) study, we analyzed through prevalent cases, years lived with disability (YLDs), age-standardized rates per 100,000 population. Temporal trends were...
Summary High‐dose melphalan (MEL) with autologous stem cell transplant (SCT) is an effective therapy for systemic AL amyloidosis (AL), but treatment‐related mortality (TRM) has historically been high. We performed a phase II trial of risk‐adapted SCT followed by adjuvant dexamethasone (dex) and thalidomide (thal) in attempt to reduce TRM improve response rates. Patients ( n = 45) newly diagnosed involving ≤2 organ systems were assigned MEL 100, 140, or 200 mg/m 2 SCT, based on age, renal...
Background and Aims. The nucleotide-binding domain leucine-rich repeat containing PYD-3 (NLRP3) inflammasome has been implicated in the pathogenesis of chronic kidney disease (CKD); however, its exact role glomerular injury tubulointerstitial fibrosis is still undefined. present study was performed to identify function NLRP3 modulating renal potential involvement mitochondrial dysfunction murine unilateral ureteral obstruction (UUO) model CKD. Methods. Employing wild-type (WT) −/− mice with...
Abstract Background Transition to enteral feeding is difficult for very low‐birth‐weight (VLBW; ≤1500 g) infants, and optimal nutrition important clinical outcomes. Method Data on practices short‐term outcomes (growth, necrotizing enterocolitis [NEC], mortality) in VLBW infants were collected from 13 neonatal intensive care units (NICUs) 5 continents (n = 2947). Specifically, NICUs Guangdong province China (GD), mainly using formula slow advancement 1366), compared with the remaining...
Skin repair remains a common problem in plastic surgery. Wound dressing plays an important role promoting local skin healing and has been widely studied. This study aimed to manufacture composite film (CPCF) containing curcumin nanoparticles, collagen, polyvinyl alcohol (PVA) effectively promote the of wounds. Sustained drug release from provides long-term protection treatment for Both antibacterial property good histocompatibility CPCF were examined by analyzing activity cytotoxicity...