A5076856558- Infant Nutrition and Health
- Neonatal and Maternal Infections
- Neonatal Respiratory Health Research
- Gut microbiota and health
- Infant Development and Preterm Care
- Child Nutrition and Water Access
- Breastfeeding Practices and Influences
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Heart Disease Studies
- Infant Health and Development
- Congenital Diaphragmatic Hernia Studies
- Birth, Development, and Health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Maternal Mental Health During Pregnancy and Postpartum
- Preterm Birth and Chorioamnionitis
- Metabolomics and Mass Spectrometry Studies
- Maternal and fetal healthcare
- Cardiovascular Conditions and Treatments
- Clinical Nutrition and Gastroenterology
- Child Nutrition and Feeding Issues
- Intestinal Malrotation and Obstruction Disorders
- Probiotics and Fermented Foods
- COVID-19 Impact on Reproduction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
James Cook University Hospital
2022
Newcastle upon Tyne Hospitals NHS Foundation Trust
2013-2020
Royal Victoria Infirmary
2015-2018
Newcastle University
2015
Late onset sepsis (LOS) in preterm infants is associated with considerable morbidity and mortality. While studies have implicated gut bacteria the aetiology of disease, functional analysis mechanistic insights are generally lacking. We performed temporal bacterial (n = 613) metabolomic 63) profiling on extensively sampled stool from 7 LOS 28 matched healthy (no or NEC) controls. The isolated diagnostic blood culture usually corresponded to dominant genera microbiome. Longitudinal changes...
The preterm microbiome is crucial to gut health and may contribute necrotising enterocolitis (NEC), which represents the most significant pathology affecting infants. From a cohort of 318 infants, <32 weeks gestation, we selected 7 infants who developed NEC (defined rigorously) 28 matched controls. We performed detailed temporal bacterial (n = 641) metabolomic 75) profiling throughout disease.A core community Klebsiella, Escherichia, Staphyloccocus, Enterococcus was present in all samples....
<b><i>Background:</i></b> Probiotics are live microbial supplements that colonize the gut and potentially exert health benefit to host. <b><i>Objectives:</i></b> We aimed determine impact of a probiotic (Infloran®: <i>Lactobacillus acidophilus</i>-NCIMB701748 <i>Bifidobacterium bifidum</i>-ATCC15696) on bacterial metabolic function preterm while in neonatal intensive care unit (NICU) following discharge....
Necrotising enterocolitis (NEC) and late-onset sepsis (LOS) are the leading causes of death among preterm infants in developed world. This study aimed to explore serum proteome metabolome longitudinally with NEC or LOS, matched controls. Nineteen patients (10 cases, 9 controls) were included. A sample 14 d prior following, as well at disease diagnosis, was included for cases. Controls had diagnosis corresponding case. All samples (n = 39) underwent shotgun proteomic analysis, 37 also...
Abstract Background Transition to enteral feeding is difficult for very low‐birth‐weight (VLBW; ≤1500 g) infants, and optimal nutrition important clinical outcomes. Method Data on practices short‐term outcomes (growth, necrotizing enterocolitis [NEC], mortality) in VLBW infants were collected from 13 neonatal intensive care units (NICUs) 5 continents (n = 2947). Specifically, NICUs Guangdong province China (GD), mainly using formula slow advancement 1366), compared with the remaining...
Abstract The development of the preterm gut microbiome is important for immediate and longer-term health following birth. We aimed to determine if modifications on neonatal intensive care unit (NICU) impacted microbiota metabolome long-term. Stool samples were collected from 29 infants ages 1–3 years post discharge (PD) a single NICU. Additional NICU included 14/29 infants. Being diagnosed with disease or receiving increased antibiotics while did not significantly impact PD. Significant...
Preterm infants are highly susceptible to late-onset sepsis (LOS) and necrotizing enterocolitis (NEC), but disease pathogenesis specific diagnostic markers lacking. Circulating cell-free DNA (cfDNA) immune cell-derived proteins involved in multiple diseases adults have not been investigated preterm neonates. We explored the relation of circulating neutrophil-associated cfDNA LOS and/or NEC. Using a clinically relevant pig model spontaneous NEC development, we plasma, together with cytokines...
Abstract Aim Changes in gut microbiota may contribute to NEC, but most studies focus on bacteria. Case reports suggest a link between cytomegalovirus (CMV) or other enteric viruses and there are few case series systematically looking at common potential viral causes. We aimed assess the presence of candidate blood stool infants with NEC managed one surgical centre. Methods identified 22 diagnosed (from November 2011 March 2014): 17 had suitable stored, whom 14 also samples stored. Blood was...
The worldwide rate of premature birth is increasing. Survival has also improved, even for very preterm infants, meaning greater numbers infants surviving into later life. This led to attention being focused on long-term outcomes. Recent interest in the Developmental Origins Health and Disease highlighted importance early life growth nutritional exposures chronic diseases such as cardiovascular disease, osteoporosis type 2 diabetes. There evidence linking poor utero with worse cognitive...
The authors have no conflicts of interest to disclose.
Spares partial least squared correlations (sPLS) between dominant bacterial genera and identified metabolites from control infants only. Analysis excludes diagnosed with late onset sepsis. Only significant based on the samples at diagnosis (time point 0) top 10 most abundant taxa were included. (PDF 145Â kb)