A5100358958- Congenital Heart Disease Studies
- RNA modifications and cancer
- DNA Repair Mechanisms
- Cardiac Arrest and Resuscitation
- Epigenetics and DNA Methylation
- Cardiac Structural Anomalies and Repair
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- Cancer-related gene regulation
- Lung Cancer Research Studies
- Helicobacter pylori-related gastroenterology studies
- Cancer Genomics and Diagnostics
- Cytokine Signaling Pathways and Interactions
- Transplantation: Methods and Outcomes
- Gastric Cancer Management and Outcomes
- Cancer-related Molecular Pathways
- Cardiovascular Issues in Pregnancy
- Pulmonary Hypertension Research and Treatments
- Liver Disease Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Lung Cancer Treatments and Mutations
- Cardiac, Anesthesia and Surgical Outcomes
- Complement system in diseases
- Genetic factors in colorectal cancer
- Neonatal Respiratory Health Research
Children's Hospital of Philadelphia
2016-2025
North China University of Science and Technology
2015-2025
Hebei Agricultural University
2025
Quzhou City People's Hospital
2024-2025
Sichuan University
2012-2024
Wuhan University of Technology
2024
Tangshan Gongren Hospital
2015-2024
Osaka University of Health and Sport Sciences
2024
West China Second University Hospital of Sichuan University
2023-2024
Dalian Municipal Central Hospital
2024
Background & Aims: Overexpression of cyclooxygenase-2 (COX-2) is implicated in many steps cancer development. Single nucleotide polymorphisms (SNPs) the COX-2 promoter might contribute to differential expression and subsequent interindividual variability susceptibility cancer. This study sought identify functional SNPs evaluated their effects on risk developing esophageal squamous cell carcinoma (ESCC). Methods: Thirty individual DNA samples were sequenced search for SNPs, function was...
Abstract The tumor suppressor P53 pathway plays a crucial role in preventing carcinogenesis and genetic variations of this may be associated with cancer susceptibility. We tested hypothesis by examining the contribution functional polymorphisms MDM2 to risk esophageal squamous cell carcinoma (ESCC). DNA from 758 ESCC patients 1,420 controls were genotyped for codon 72Arg>Pro 309T>G polymorphisms. Odds ratios (OR) 95% confidence intervals (CI) estimated logistic regression....
Adenosine diphosphate ribosyl transferase (ADPRT) and X-ray repair cross-complementing 1 (XRCC1) are two major DNA base excision (BER) proteins act interactively in stimulating executing BER processes. Polymorphisms of ADPRT Val762Ala XRCC1 Arg399Gln have been associated with altered protein function activity. This case-control study examined the contribution these polymorphisms, alone combination, or interaction smoking, to risk developing lung cancer. We estimated cancer polymorphisms...
Abstract The Himalaya–Hengduan Mountains encompass two global biodiversity hotspots with high levels of and endemism. This area is one the diversification centres genus Rhododendron , which recognized as most taxonomically challenging plant taxa due to recent adaptive radiations rampant hybridization. In this study, four DNA barcodes were evaluated on 531 samples representing 173 species seven sections subgenera in a sampling density from employing three analytical methods. varied approaches...
Intubation in children is increasingly performed using video laryngoscopes. Many pediatric studies examine novice laryngoscopists or describe single patient experiences. This prospective randomized nonblinded equivalence trial compares intubation time for the GlideScope Cobalt® laryngoscope (GCV, Verathon Medical, Bothell, WA) with direct laryngoscopy a Miller blade (DL, Heine, Dover, NH) anatomically normal neonates and infants. The primary hypothesis was that times GCV would be noninferior...
EBV encodes 44 mature microRNAs, which have been proven to promote EBV-associated diseases by targeting host genes and self-viral genes. In carcinomas, the expression of viral protein is limited but BART microRNAs extremely high, suggesting that they could be major factors in contribution tumorigenesis. p53 a critical tumor suppressor. Unlike most human solid tumors, TP53 mutations are rare nasopharyngeal carcinoma gastric tissues, possibility some EBV-encoded products suppress functions...
BACKGROUND: The United Network of Organ Sharing made changes to the priority for allocation hearts transplantation (HT) in 2016 pediatric patients and 2018 adult patients. Although recent work has evaluated impact revised systems on mechanical circulatory support practices waitlist outcomes, there are limited data that focus more specifically with congenital heart disease (CHD) or cardiomyopathy how these relationships might differ METHODS: database was queried (<18 years age) (18–50 a...
Background. Outcomes studies often need a level of detail that is not present in administrative data, therefore requiring abstraction medical charts. Case-control methods may be used to improve statistical power and reduce costs, but limitations exact matching preclude the use many covariates. Unlike matching, multivariate allow cases matched simultaneously on hundreds Objectives. To develop case-control pairs study death after surgery Medicare population. Research Design. Using 830 randomly...
The tumor suppressor TP53 pathway plays a crucial role in preventing carcinogenesis through its ability to impose cell cycle arrest and apoptosis following DNA damage oncogene activation. MDM2 is key negative regulator of the overexpressed many cancers as oncoprotein. We investigated association between genetic variation promoter region (c.-5+309G>T, rs2279744:g.G>T) coding (c.215G>C, rs1042522:g.G>C, designated Arg72Pro) risk developing lung cancer. genotypes 1,106 patients 1,420 controls...
The FAS receptor–ligand system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate tumor-immune escape carcinogenesis. We have recently demonstrated (Sun, T., X. Miao, Zhang, W. Tan, P. Xiong, D. Lin. 2004. J. Natl. Cancer Inst. 96:1030–1036; X., T. Sun, S. Qu, Y. Zhou, 2005. Med. Genet. 42:479–484) that functional polymorphisms ligand (FASL) are associated with susceptibility lung cancer esophageal cancer; however, the...
In estrogen responsive MCF-7 cells, estradiol (E2) binding to ERα leads transcriptional regulation of genes involved in the control cell proliferation and survival. MicroRNAs (miRNAs) have emerged as key post-transcriptional regulators gene expression. The aim this study was explore whether miRNAs were hormonally regulated expression genes. Western blot QPCR used determine respectively. Target by validated luciferase reporter assays transfection miRNA mimics or inhibitors. Cell evaluated MTS...
The association between chest compression (CC) pause duration and pediatric in-hospital cardiac arrest survival outcomes is unknown. American Heart Association has recommended minimizing pauses in CC children to <10 seconds, without supportive evidence. We hypothesized that longer maximum durations are associated with worse neurological outcomes.
Postoperative complications are common in the Medicare population, yet no study has formally quantified change prognosis that occurs after a broad range of first complications.We sought to estimate relative severity 24 postoperative undertook multivariate matched, population-based, case-control death surgery sample 1362 Pennsylvania patients.Cases (681 deaths) were selected randomly using claims from 1995-1996. Models developed scan all claims, looking for similar controls did not die.Charts...
Abstract Purpose: Fas-Fas ligand (FasL)–mediated death pathway is important in the life and of immune cells and, therefore, influences surveillance carcinogenesis. This study examined association between functional variants Fas (−1377G→A −670A→G), FasL (−844T→C), caspase-8 (CASP8) six-nucleotide deletion polymorphism (−652 6N ins→del) risk pancreatic cancer. Experimental Design: Genotypes were determined 397 cases with cancer 907 controls. Odds ratios (OR) 95% confidence intervals (95% CI)...
Sulfotransferase isoform 1A1 (SULT1A1) is the most highly expressed hepatic sulfotransferase and involved in biotransformation of a wide variety endo- xenobiotics. A common single nucleotide polymorphism (SNP) coding region SULT1A1, several proximal promoter SNPs, copy number variation (CNV) are associated with altered enzymatic activity, but these variants do not fully account for observed SULT1A1 activity human populations. In order to identify additional SNPs modulating we examined...
Background— Patients with repaired tetralogy of Fallot experience variable outcomes for reasons that are incompletely understood. We hypothesize genetic variants contribute to this variability. sought investigate the association 22q11.2 deletion status clinical outcome in patients Fallot. Methods and Results— performed a cross-sectional study subjects who were tested deletion, underwent cardiac magnetic resonance, exercise stress test, review medical history. studied 165 (12.3±3.1 years),...
Background Prenatal diagnosis of single ventricle-type congenital heart disease is associated with improved clinical courses. counseling allows for optimal delivery preparations and opportunity prenatal intervention. Expectant parents frequently ask what the likelihood survival through staged palliation factors that influence outcome. Our goal was specifically to quantify peri- postnatal outcomes in this population. Methods Results We identified all patients a presenting between July 2004...