A5101694772- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Lipid metabolism and disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Diabetes and associated disorders
- Gastrointestinal disorders and treatments
- Gastrointestinal motility and disorders
- Multiple Myeloma Research and Treatments
- Diet, Metabolism, and Disease
- Diverse Scientific Research Studies
- bioluminescence and chemiluminescence research
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Olfactory and Sensory Function Studies
- Clostridium difficile and Clostridium perfringens research
- Protein Degradation and Inhibitors
- Congenital gastrointestinal and neural anomalies
- Dialysis and Renal Disease Management
- Pancreatic function and diabetes
- Angiogenesis and VEGF in Cancer
- Piperaceae Chemical and Biological Studies
- Tryptophan and brain disorders
- Digestive system and related health
Shanghai First People's Hospital
2012-2025
Shanghai Jiao Tong University
2014-2023
Affiliated Hospital of Southwest Medical University
2021
Nanjing Medical University
2019
Chunlan (China)
2016
Abstract Recent reports have suggested that the gut microbiota is involved in progression of colorectal cancer (CRC). The composition CRC precursors has not been adequately described. To characterize structure adherent this disease, we conducted pyrosequencing-based analysis 16S rRNA genes to determine bacterial profile normal colons (healthy controls) and adenomas (CRC precursors). Adenoma mucosal biopsy samples adjacent colonic mucosa from 31 patients with 20 healthy volunteers were...
Hypertriglyceridemia (HTG) aggravates the course of acute pancreatitis (AP). Intestinal barrier dysfunction is implicated in pathogenesis AP during which dysbiosis intestinal microbiota contributes to barrier. However, few studies focus on changes intestine HTG-related necrotizing (ANP). Here, we investigated and Paneth cell antimicrobial peptides (AMPs) ANP (HANP) rats. Rats fed a high-fat diet induce HTG was induced by retrograde injection 3.5% sodium taurocholate into biliopancreatic...
Intestinal barrier dysfunction plays an important role in acute necrotizing pancreatitis (ANP) and intestinal microbiota dysbiosis was involved failure. Paneth cells protect are associated with microbiota. Here, we investigated changes antimicrobial peptides of ileum during ANP.Rats ANP were established by retrograde injection 3.5% sodium taurocholate into biliopancreatic duct sacrificed at 24h 48h, respectively. Injuries pancreas distal evaluated histopathological score. function assessed...
Toll-like receptor 4 (TLR4) has been identified as a potentially promising therapeutic target in acute pancreatitis (AP). However, the role of intestinal TLR4 AP and AP-associated gut injury remains unclear. This study aimed to explore relationship between microbiota during AP. A mouse model was establish by intraperitoneal injection L-arginine. Pancreatic barrier function were evaluated wild-type epithelial knockout (TLR4ΔIEC) mice. Gut analyzed 16S rRNA sequencing. Quadruple antibiotics...
Aim : To analyze the features and treatment of hypertriglyceridemia‐induced acute pancreatitis (HTGP) during pregnancy. Methods A retrospective study 21 pregnant women diagnosed with (AP) was performed. Patients were divided into biliary (ABP), HTGP, idiopathic groups according to etiology. Results 95% patients in third trimester gestation. The percentage HTGP higher than that ABP (48% vs.14%). severe (SAP) group (40.0% vs.0%). Ranson scores for moderately (MSAP) SAP significantly different...
An increase of Escherichia-Shigella was previously reported in acute necrotizing pancreatitis (ANP). We investigated whether Escherichia coli MG1655, an commensal organism, increased intestinal injury and aggravated ANP rats. induced by retrograde injection 3.5% sodium taurocholate into the biliopancreatic duct. Using gut microbiota-depleted rats, we demonstrated that microbiota involved pancreatic barrier dysfunction ANP. 16S rRNA gene sequencing quantitative PCR, found dysbiosis a...
Mucin-2 (MUC2) secreted by goblet cells participates in the intestinal barrier, but its mechanism acute necrotizing pancreatitis (ANP) remains unclear. In (AP) patients, functions of (MUC2, FCGBP, CLCA1, and TFF3) decreased, MUC2 was negatively correlated with AP severity. ANP rats treated pilocarpine (PILO) (PILO+ANP rats) to deplete showed more serious pancreatic colonic injuries, cell dysfunction, gut dysbiosis, bacterial translocation than those rats. GC-MS analysis feces that PILO+ANP...
Aim . To investigate the epidemiology, etiology, and severity of acute pancreatitis (AP) in urban suburban areas Shanghai 2011 2016. Methods A retrospective study patients admitted to General Hospital (urban campuses) with AP 2016 was undertaken. Patients were divided into biliary (ABP), hypertriglyceridemic (HTGP), alcoholic pancreatitis, other causes according etiology. Severity mild (MAP), moderately severe (MSAP), (SAP). Results area increased more rapidly than those area. The mean onset...
We demonstrate that AP patients and experimental mice exhibited a dysfunction of Paneth cells. Our in vivo research showed the severity was exacerbated by long-term cells, which associated with gut microbiota disorder.
We previously reported that acute necrotizing pancreatitis (ANP) after normal or high-fat diet is associated with a decreased number of Paneth cells in ileal crypts. Here, we ablated rat model ANP and to investigate the effects on disease symptoms. Adult male Sprague-Dawley rats received standard chow for 2 weeks, which they were treated dithizone deplete cells. Six hours later, was established by retrograde injection sodium taurocholate into biliopancreatic duct. Rats sacrificed at 6, 12,...
The present work aimed to investigate the role of Paneth cells in small intestinal injury during acute necrotizing pancreatitis (ANP) using rat models established by injection dithizone, a metal chelator zinc with ability selectively ablate cells. Sprague‑Dawley rats were randomly divided into four groups: Sham‑operated group, ANP group (3.5% sodium taurocholate solution, 1 ml/kg body weight), dithizone (100 mg/kg weight) and + (sodium solution was administered 6 h after injection). Each...
Monocytes play an important role in acute pancreatitis (AP). Hypertriglyceridemic (HTGP) is always more severe than normal lipid-AP, whether the mechanism of aggravation involves monocyte subsets remains unknown though. The present study was aimed to analyze changes peripheral blood M1 and M2 monocytes HTGP patients. A total 90 subjects were enrolled, among which 16 diagnosed with HTGP, 34 biliary (ABP), 20 hypertriglyceridemia (HTG), healthy controls (HC). Peripheral CD14+CD86+ CD14+CD206+...
Piperlongumine, an alkaloid compound extracted from Peper longum L, has been reported to produce neuroprotective effects in the brain and exert various pharmacological activities such as antitumor, antiangiogenic, anti-inflammatory analgesic properties. The aim of this study was investigate antidepressant-like possible mechanism action piperlongumine a chronic unpredictable stress (CUS) model. We found that, with venlafaxine positive control, orally administered (12.5 25 mg/kg) for 7 days,...
This study aimed to investigate the value of peripheral blood neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte (LMR) in prognosis patients with multiple myeloma (MM).