A5101623857- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Hepatitis C virus research
- Liver Diseases and Immunity
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Pharmacological Effects of Natural Compounds
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- TGF-β signaling in diseases
- Wnt/β-catenin signaling in development and cancer
- Immune cells in cancer
- Gallbladder and Bile Duct Disorders
- Lipid metabolism and disorders
- Cancer Mechanisms and Therapy
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
- Cancer-related molecular mechanisms research
- HIV/AIDS drug development and treatment
- Pharmacogenetics and Drug Metabolism
- Plant Micronutrient Interactions and Effects
Shanghai First People's Hospital
2015-2025
Shanghai Jiao Tong University
2015-2025
Kaohsiung Medical University
2024
Kaohsiung Medical University Chung-Ho Memorial Hospital
2024
Zhejiang Chinese Medical University
2024
Nanjing University of Chinese Medicine
2024
Nanjing Medical University
2016-2021
Shanghai Medical College of Fudan University
2016
Renji Hospital
2002-2009
Chronic hepatitis C virus (HCV) infection is relatively frequent in China. This study investigated the clinical, demographic, and viral host genetic characteristics that may influence disease manifestations clinical management.In this cross-sectional observational study, treatment-naïve Han ethnic adults with recently confirmed chronic HCV were enrolled at 28 hospitals across genotype interleukin 28B (IL28B) genotypes determined compared patient demographic parameters medical status.Among...
Abstract H. pylori-induced chronic inflammation is considered the most important cause of gastric cancer. The actual process how triggers carcinogenesis still not clear. In this study, neutrophils and relative markers in cancer development were examined with immunohistochemistry fluorescence RNA situ hybridization methods. On average, 24 times more found tissues about 9 intestinal metaplasia comparing to normal tissue controls. CagA + pylori infection adjacent or EBV did increase neutrophil...
Cholestatic liver disease is a group of diseases in which bile acid accumulates the for various reasons, resulting abnormal biochemical indicators and histological damage. Cholestasis can be divided into intrahepatic cholestasis extrahepatic cholestasis, will contribute to damage progress fibrosis cirrhosis. Primary biliary cholangitis (PBC) primary sclerosing are two most typical cholestatic diseases. Ursodeoxycholic currently first-line treatment PBC, while obeticholic acid, budesonide...
Little is known on the cost-effectiveness of novel regimens for hepatitis C virus (HCV) compared with standard-of-care pegylated interferon (pegIFN) and ribavirin (RBV) therapy in developing countries. We evaluated sofosbuvir/ledipasvir 12 weeks a 48-week pegIFN-RBV regimen Chinese patients genotype 1b HCV infection by economic regions.A decision analytic Markov model was developed to estimate quality-adjusted-life-years, lifetime cost incremental ratios (ICERs). SVR rates direct medical...
Matrine (MT), the effective component of Sophora flavescens Ait, has been shown to have anti-inflammation, immune-suppressive, anti-tumor, and anti-hepatic fibrosis activities. However, pharmacological effects MT still need be strengthened due its relatively low efficacy short half-life. In present study, we report a more thio derivative MT, MD-1, inhibitory on activation hepatic stellate cells (HSCs) in both cell culture animal models. Cytological experiments showed that MD-1 can inhibit...
In 2015, the Chinese Society of Hepatology and Gastroenterology published a consensus on primary biliary cholangitis (PBC). past years, numerous clinical studies have been in field PBC. To guide diagnosis management PBC patients, invited panel experts to assess new evidence formulate current guidelines.
Abstract Ghrelin is a gastric peptide that modulates various biological functions, including potential anti‐inflammatory and antifibrotic properties. Increasingly evidence have demonstrated exosomes derived from injured hepatocytes (IHC‐Exo) can accelerate the activation of hepatic stellate cells (HSCs) liver fibrosis. Ferroptosis, type novel programmed cell death, regulates diverse pathological processes, However, it remains unclear whether ghrelin exerts its effect through mechanisms...
Liver fibrosis is a key process in the progression of chronic liver diseases. However, there are currently no drugs specifically designed to treat fibrosis. Our Phase 2 trial hydronidone for treatment hepatitis B (CHB)-associated showed that adding entecavir resulted significant reversal To further evaluate efficacy 270 mg/day dose treating associated with CHB, we conducted this 3 trial. This 52-week, randomized (1:1), double-blind, placebo-controlled, multicenter, entecavir-based clinical...
Introduction Hereditary haemochromatosis (HH) caused by a homozygous p.C282Y mutation in ( HFE ) gene has been well documented. However, less is known about the causative non- mutation. We aimed to assess patterns of haemochromatosis-related genes Chinese patients with primary iron overload. Methods Patients were preanalysed for mutations classic HH-related genes: , HJV HAMP TFR2 and SLC40A1 . Whole exome sequencing was conducted cases variants signal peptide region. Representative analysed...
Abstract Background and Purpose Liver fibrosis is a wound‐healing reaction that eventually leads to cirrhosis. Hydronidone new pyridine derivative with the potential treat liver fibrosis. In this study, we explored antifibrotic effects of hydronidone its mode action. Methods The anti‐hepatic were studied in carbon tetrachloride (CCl 4 )‐ 3,5‐diethoxycarbonyl‐1,4‐dihydrocollidine (DDC)‐ induced animal mechanisms investigated hepatic stellate cells (HSCs). effect was further tested after Smad7...
There have been few reports on the simultaneous isolation of multiple liver cell populations thus far. As such, this study was aimed at establishing a protocol for separation hepatocytes (HCs), hepatic stellate cells (HSCs), sinusoidal endothelial (LSECs) and Kupffer (KCs) from rat assessing in vitro culture these cells. Single-cell suspensions were obtained by ethylene glycol tetraacetic acid/collagenase perfusion. After low-speed centrifugal HCs, pronase added to nonparenchymal fraction...
We previously reported that acute necrotizing pancreatitis (ANP) after normal or high-fat diet is associated with a decreased number of Paneth cells in ileal crypts. Here, we ablated rat model ANP and to investigate the effects on disease symptoms. Adult male Sprague-Dawley rats received standard chow for 2 weeks, which they were treated dithizone deplete cells. Six hours later, was established by retrograde injection sodium taurocholate into biliopancreatic duct. Rats sacrificed at 6, 12,...
INTRODUCTION: Endoscopic transmural drainage (TMD) has been accepted as the preferred therapy for symptomatic pancreatic fluid collections (PFCs). Recurrence of PFCs presents a unique challenge in patients with disrupted duct (PD). We aimed to evaluate whether transpapillary (TPD) provides additional benefits TMD PD disruption. METHODS: This was multicenter retrospective study. Consecutive who underwent TMD, TPD, or combined (CD) were included. The primary outcome compare PFC recurrence...
Although cytologic examination of biliary stricture brushings obtained by endoscopic retrograde cholangiopancreatography is commonly used for diagnosing malignant strictures (MBSs), it has low sensitivity. Several new brushes have capabilities that are still being debated. We developed a novel brush working from conventional back-and-forth movement to rotation in situ (RIS) may be more efficient MBS sampling. aimed compare the detection sensitivity our RIS with brush.
Cytokeratin19 positive (CK19+) hepatocellular carcinoma (HCC) is thought to derive from liver progenitor cells (LPC). However, whether peritumoralductular reaction (DR) differs between CK19+ and CK19 negative (CK19-) HCC patients remains unclear.One hundred twenty HBV-related were enrolled in this study. Clinicopathological variables collected, immunohistochemistry staining for CK19, proliferating cell nuclear antigen (PCNA), interleukin-6 (IL-6) β-catenin performed tumor peritumor...
Goals: To comprehensively compare the wet suction technique with conventional dry for endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in solid lesions. Background: Optimal techniques EUS-FNA remain uncertain when approaching Study: We performed a retrospective study of at 3 medical centers China. A total 203 patients were enrolled who received 2 passes 22-G needles. If first pass underwent suction, second was suction. Otherwise, order is opposite. Diagnostic accuracy, sample...