A5021498685- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Lung Cancer Research Studies
- Phytochemistry and Bioactive Compounds
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- Endometrial and Cervical Cancer Treatments
- Cancer Cells and Metastasis
- Lung Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Natural product bioactivities and synthesis
- Protein Degradation and Inhibitors
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ovarian cancer diagnosis and treatment
- Immune cells in cancer
The University of Texas MD Anderson Cancer Center
2017-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Soochow University
2023-2025
University of Science and Technology of China
2024-2025
First Affiliated Hospital of Soochow University
2023-2025
Nanjing University of Chinese Medicine
2025
Dalian Medical University
2018-2025
First Affiliated Hospital of Dalian Medical University
2018-2025
Huazhong University of Science and Technology
2019-2024
Central Hospital of Wuhan
2022-2024
Isocitrate dehydrogenase (IDH)-mutant grade 2 gliomas are malignant brain tumors that cause considerable disability and premature death. Vorasidenib, an oral brain-penetrant inhibitor of mutant IDH1 IDH2 enzymes, showed preliminary activity in IDH-mutant gliomas.
Abstract The relevance of KRAS mutation alleles to clinical outcome remains inconclusive in pancreatic adenocarcinoma (PDAC). We conducted a retrospective study 803 patients with PDAC (42% metastatic disease) at MD Anderson Cancer Center. Overall survival (OS) analysis demonstrated that status and subtypes were prognostic ( p < 0.001). Relative wildtype tumors (median OS 38 months), G12R had similar 34 while Q61 G12D mutated shorter 20 months [HR: 1.9, 95% CI 1.2–3.0, = 0.006] 22 1.7,...
A recent epidemic of melamine contamination baby formula in China has been associated with the development urinary tract stones, though clinical manifestations and predisposing factors are incompletely delineated.We administered a questionnaire to parents children 36 months age or younger who were being screened for history exposure symptoms of, possible for, stones. In addition, we performed urinalysis, renal-function liver-function tests, tests biochemical markers calcium:creatinine ratio,...
Abstract Purpose: Isocitrate dehydrogenase (IDH) gene mutations occur in low-grade and high-grade gliomas. We sought to identify the genetic basis of malignant phenotype heterogeneity IDH-mutant Methods: prospectively implanted tumor specimens from 20 consecutive IDH1-mutant glioma resections into mouse brains genotyped all resection using a CLIA-certified molecular panel. Gliomas with cancer driver were tested for sensitivity targeted inhibitors vitro. Associations between genomic...
miR-31 (microRNA-31) is frequently altered in numerous cancers. The aim of the present study was to investigate role ESCC (oesophageal squamous cell carcinoma). We measured 45 paired tissues and 523 serum samples using real-time RT (reverse transcription)–PCR. were divided into a discovery group (120 ESCCs 121 normal controls), validation (81 81 final comprising six other common tumours (colorectal, liver, cervical, breast, gastric lung cancers; total n=120). A Mann–Whitney U test Wilcoxon...
Lung carcinoma is the most common human cancer with poor prognosis and has an increasing incidence in recent years. However, related mechanism of lung onset not been completely explored. Piwi-interacting RNA (piRNA) a type noncoding small established function germ cells, interestingly, piRNA also shown to be implicated biology. In this study, piR-55490 was found silenced specimens cell lines, compared normal tissues cells. Intriguingly, expression level negatively associated patients'...
In this study, gelatin-based absorbents were realized <italic>via</italic> an environmentally friendly freeze-drying process followed by chemical vapor deposition.
The EXTEND trial tested the hypothesis that adding comprehensive metastasis-directed therapy (MDT) to chemotherapy would improve progression-free survival (PFS) over alone among patients with oligometastatic pancreatic ductal adenocarcinoma (PDAC).
603 Background: Standard treatment of oligometastatic pancreatic ductal adenocarcinoma (PDAC) consists multi-agent chemotherapy, although outcomes remain poor. We tested the hypothesis that addition comprehensive metastasis-directed therapy (MDT) to standard-of-care systemic would improve progression-free survival (PFS) compared with alone. Methods: The External Beam Radiation Eliminate Nominal Metastatic Disease (EXTEND) trial is a multicenter phase II basket randomizing patients ≤ 5 solid...
The FAS receptor–ligand system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate tumor-immune escape carcinogenesis. We have recently demonstrated (Sun, T., X. Miao, Zhang, W. Tan, P. Xiong, D. Lin. 2004. J. Natl. Cancer Inst. 96:1030–1036; X., T. Sun, S. Qu, Y. Zhou, 2005. Med. Genet. 42:479–484) that functional polymorphisms ligand (FASL) are associated with susceptibility lung cancer esophageal cancer; however, the...
Abstract Preoperational hemogram parameters have been reported to be associated with the prognosis of several types cancers. This study aimed investigate prognostic value hematological in gastric cancer a Chinese population. A total 870 patients who underwent radical tumorectomy were recruited from January 2008 December 2012. Preoperative recorded and dichotomized by time-dependent receiver operating characteristic curves. The survival curves stratified each parameter plotted Kaplan–Meier...
Collagen is widely used in biomedical applications due to its outstanding properties. In this study, highly porous sponge scaffolds were developed by using porcine skin-derived collagen (PSC) and fish scale-derived (FSC), respectively. The morphology composition of these PSC FSC compared. water uptake ratio reached 47.8, which 1.7 times scaffolds. vapour transmission rates (WVTR) 952.6 ± 55.5 1090.9 77.1 g/m
The FAS-FASL system plays crucial role in counterattack of cancer cell against immune system. This study examined the effects FAS (-1377G/A and -670A/G) FASL (-844T/C 7896G/C) polymorphisms on breast risk apoptosis T lymphocytes. effect was determined by case-control analysis 840 patients controls. T-lymphocyte were activation-induced death (AICD) cells ex vivo analyzing apoptotic tumor-infiltrating lymphocytes (TILs) tissue. We found moderately increased associated with -1377AG [odds ratio...
Aberrant arachidonic acid metabolism by cyclooxygenase (COX)-2 and 12-lipoxygenase (LOX) has implicated in carcinogenesis. Genetic polymorphisms COX-2 12-LOX might therefore affect susceptibility to colorectal cancer (CRC). To examine this hypothesis, genotypes of -1290A>G, -1195G>A, -765G>C 261Arg>Gln were determined 1000 CRC patients 1300 controls. Increased risk developing was associated with the -1195GA [adjusted odds ratio (OR) = 1.24, 95% confidence interval (CI) 1.00-1.54] -1195AA...
Abstract Purpose: Fas-Fas ligand (FasL)–mediated death pathway is important in the life and of immune cells and, therefore, influences surveillance carcinogenesis. This study examined association between functional variants Fas (−1377G→A −670A→G), FasL (−844T→C), caspase-8 (CASP8) six-nucleotide deletion polymorphism (−652 6N ins→del) risk pancreatic cancer. Experimental Design: Genotypes were determined 397 cases with cancer 907 controls. Odds ratios (OR) 95% confidence intervals (95% CI)...