A5100460269- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Breast Lesions and Carcinomas
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Advanced Radiotherapy Techniques
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Research Studies
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Glycosylation and Glycoproteins Research
- Neuroendocrine Tumor Research Advances
- Peptidase Inhibition and Analysis
- Lysosomal Storage Disorders Research
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Hepatocellular Carcinoma Treatment and Prognosis
- Sarcoma Diagnosis and Treatment
Harbin Institute of Technology
2025
Chinese Academy of Sciences
1998-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Taiyuan University of Technology
2021-2024
Cincinnati Children's Hospital Medical Center
2024
Institute of Semiconductors
2024
Nanchang Institute of Technology
2024
Ganzhou People's Hospital
2023-2024
Tianjin Medical University Cancer Institute and Hospital
2011-2023
Chinese PLA General Hospital
2022-2023
Breast cancer is one of the most common malignancies and major cause cancer-related death in women. Although importance PIWI-interacting RNAs (piRNAs) has been increasingly recognized, few studies have explored functional mechanism piRNAs breast development progression.We examined top 20 highly expressed based on analysis TCGA data two patient cohorts to test roles cancer. The effects piRNA-36,712 malignant phenotypes chemosensitivity cells were detected vitro vivo. MS2-RIP reporter gene...
Tuberous Sclerosis Complex (TSC) is an autosomal dominant, multi-system disorder, typically involving severe neurological symptoms, such as epilepsy, cognitive deficits and autism. Two genes, TSC1 TSC2, encoding the proteins hamartin tuberin, respectively, have been identified causing TSC. Although there a substantial overlap in clinical phenotype produced by TSC2 mutations, accumulating evidence indicates that mutations cause more manifestations than mutations. In this study, of novel mouse...
The role of miR-26a in carcinogenesis appears to be a complicated one, the sense that both oncogenic and tumor suppressive effects were reported cancers such as glioblastoma hepatocellular carcinoma, respectively. Here, we report for first time is downregulated breast cancer specimens cell lines its transient transfection initiates apoptosis line MCF7 cells. Furthermore, retrovirus-delivered impairs vitro colony forming vivo tumor-loading ability Subsequently, MTDH EZH2 are identified two...
Abstract Radiation enteritis (RE) is the most common complication of radiotherapy for pelvic irradiation receivers. Herein we investigated alterations in gut microbial profiles and their association with patients undergoing radiotherapy. Faecal samples were collected from 18 cervical cancer during Microbiota characterized based on 16S rRNA sequencing using Illumina HiSeq platform. Epithelial inflammatory response was evaluated bacterial‐epithelial co‐cultures. Dysbiosis observed among RE,...
Tumor cells display fundamental changes in metabolism and nutrient uptake order to utilize additional sources meet their enhanced bioenergetic requirements. Glutamine (Gln) is one such that rapidly taken up by tumor fulfill this increased metabolic demand. A vital step the catabolism of glutamine its conversion glutamate mitochondrial enzyme glutaminase (GLS). This study has identified GLS a potential therapeutic target breast cancer, specifically basal subtype exhibits deregulated...
Monoacylglycerol lipase (MAGL) represents a primary degradation enzyme of the endogenous cannabinoid (eCB), 2-arachidonoyglycerol (2-AG). This study reports potent covalent MAGL inhibitor, SAR127303. The compound behaves as selective and competitive inhibitor mouse human MAGL, which potently elevates hippocampal levels 2-AG in mice. In vivo, SAR127303 produces antinociceptive effects assays inflammatory visceral pain. addition, drug alters learning performance several related to episodic,...
Rationale: Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptor alpha (ER-α), human epidermal growth factor 2 (HER2) and progesterone (PR) expression, but effect lacking three factors on TNBC unclear. Whether loss contributes to deregulate genes that participate in progress remains unknown. Methods: We performed microRNA arrays comprehensive analysis screen for miRNAs are transcriptionally regulated ER-α, HER2 PR. Functional assays molecular mechanism...
To assess the validity and cost of a screening test for primary liver cancer using combined serum alpha fetoprotein testing ultrasonography.An urban community in Shanghai, China.9373 subjects aged 35 to 59 with positive hepatitis B surface antigen (HBsAg) or chronic were studied. Outcome measures detection rate, false predictive value, each detected, average detecting additional by method. The number small cancers detected was used economic evaluation.20,294 examinations carried out. Primary...
No standard chemotherapy is used as neoadjuvant therapy in triple negative breast cancer (TNBC). This study has compared carboplatin plus paclitaxel with commonly epirubicin (NAC) TNBC.91 patients a median age of 47 years (PC patients, EP 44 patients) were enrolled. 65% the premenopausal. While objective response rate was similar PC and arm (89.4% vs. 79.5%, P = 0.195), pCR significantly higher (38.6% 14.0%, 0.014). The follow-up time 55.0 months. 5-year RFS 77.6% 56.2%, arm, 0.043....
Background: Neuronopathic Gaucher disease (nGD) is a rare neurodegenerative disorder caused by biallelic mutations in GBA and buildup of glycosphingolipids lysosomes. Neuronal injury cell death are prominent pathological features; however, the role individual types involvement microglia, blood-derived macrophages, immune infiltrates nGD pathophysiology remains enigmatic. Methods: Here, using single-cell resolution mouse brains, lipidomics, newly generated biomarkers, we found induction...
Abstract Background: Breast cancer is ranked among the most prevalent malignancies in Chinese female population. However, comprehensive reports detailing latest epidemiological data and attributable disease burden have not been extensively documented. Methods: In 2018, high-quality surveillance were recorded 700 population-based registries China. We extracted on breast cancers (International Classification of Diseases, Tenth Revision [ICD-10]: C50) estimated incidence mortality 2022...
The FAS-FASL system plays crucial role in counterattack of cancer cell against immune system. This study examined the effects FAS (-1377G/A and -670A/G) FASL (-844T/C 7896G/C) polymorphisms on breast risk apoptosis T lymphocytes. effect was determined by case-control analysis 840 patients controls. T-lymphocyte were activation-induced death (AICD) cells ex vivo analyzing apoptotic tumor-infiltrating lymphocytes (TILs) tissue. We found moderately increased associated with -1377AG [odds ratio...
Aberrant arachidonic acid metabolism by cyclooxygenase (COX)-2 and 12-lipoxygenase (LOX) has implicated in carcinogenesis. Genetic polymorphisms COX-2 12-LOX might therefore affect susceptibility to colorectal cancer (CRC). To examine this hypothesis, genotypes of -1290A>G, -1195G>A, -765G>C 261Arg>Gln were determined 1000 CRC patients 1300 controls. Increased risk developing was associated with the -1195GA [adjusted odds ratio (OR) = 1.24, 95% confidence interval (CI) 1.00-1.54] -1195AA...
Abstract As the malignancy with highest global incidence, breast cancer represents a significant threat to women’s health. Recent advances have shed light on importance of mitochondrial function in cancer, particularly metabolic reprogramming within tumors. Recognizing this, we developed novel risk signature based mitochondrial-related genes improve prognosis prediction and stratification patients. In this study, transcriptome data clinical features samples were extracted from two sources:...