A5016780523- Pancreatic and Hepatic Oncology Research
- Genomics and Rare Diseases
- French Urban and Social Studies
- Cancer Genomics and Diagnostics
- Social Sciences and Governance
- Neuroscience and Neuropharmacology Research
- CRISPR and Genetic Engineering
- Genetic factors in colorectal cancer
- PARP inhibition in cancer therapy
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- TGF-β signaling in diseases
- Advanced Breast Cancer Therapies
- Cancer Research and Treatments
- European Political History Analysis
- Hippo pathway signaling and YAP/TAZ
- Colonialism, slavery, and trade
- Historical Studies and Socio-cultural Analysis
- Diabetes Treatment and Management
- Cancer-related gene regulation
- Neurogenesis and neuroplasticity mechanisms
- Colorectal Cancer Treatments and Studies
- interferon and immune responses
- Barrier Structure and Function Studies
- Pancreatic function and diabetes
Sanofi (France)
1993-2023
University of Mauritius
2017-2023
Hôpital Saint-Michel
2018
Conservatoire National des Arts et Métiers
1997-2017
Centre Hospitalier Universitaire de Rennes
2015
Institut de Biologie du Développement Marseille
2002-2005
Harvard University
1995-1998
McLean Hospital
1994-1998
Université Laval
1998
University of Technology, Jamaica
1990
Crumbs is an apical transmembrane protein crucial for epithelial morphogenesis in Drosophila melanogaster embryos. A with all the characteristics a homologue has been identified from patients suffering retinitis pigmentosa group 12, but this (CRB1) only expressed retina and some parts of brain, both human mouse. Here, we describe CRB3, another that preferentially tissues skeletal muscles human. CRB3 shares conserved cytoplasmic domain other exhibits very short extracellular without EGF-...
Monoacylglycerol lipase (MAGL) represents a primary degradation enzyme of the endogenous cannabinoid (eCB), 2-arachidonoyglycerol (2-AG). This study reports potent covalent MAGL inhibitor, SAR127303. The compound behaves as selective and competitive inhibitor mouse human MAGL, which potently elevates hippocampal levels 2-AG in mice. In vivo, SAR127303 produces antinociceptive effects assays inflammatory visceral pain. addition, drug alters learning performance several related to episodic,...
dCrumbs is an apical organizer crucial for the maintenance of epithelial polarity in Drosophila(1Knust E. Curr. Opin. Genet. Dev. 2000; 10: 471-475Crossref PubMed Scopus (49) Google Scholar). It known that interacts with Discs lost (Dlt), a protein four PDZ (PSD95/Discs Large/ZO-1) domains (2Bhat M.A. Izaddoost S., Lu, Y. Cho K.O. Choi K.W. Bellen H.J. Cell. 1999; 96: 833-845Abstract Full Text PDF (239) Scholar), and Stardust (Sdt), MAGUK (membrane-associated guanylate kinase) family (3Hong...
The Crumbs complex that also contains the cortical proteins Stardust and DPATJ (a homologue of PATJ), is crucial for building epithelial monolayers in Drosophila. Although loss function or genes prevents stabilization a belt adherens junctions at apico-lateral border cells, no phenotype has been described Dpatj gene its role morphogenesis polarity remains unknown. We have produced downregulated PATJ stable lines Caco2 to clarify morphogenesis. In knockdown Pals1 homologue) longer associated...
We developed a new approach to study single- and double-stranded DNA breaks during chronic, moderate excitotoxicity resulting from the inhibition of glutamate transporter in cerebellar granule cell primary cultures. A 24 hr treatment 2-week-old cultures with L-alpha- amino adipate (LAA), an inhibitor uptake transporter, caused gradual extracellular accumulation endogenous that induced reversible morphological change neurons but no neuronal death despite sustained, moderate, elevations free...
Abstract Human adipose tissue (hAT) is constituted of structural units termed lobules, the organization which remains to be defined. Here we report that lobules are composed two extracellular matrix compartments, i.e., septa and stroma, delineating niches CD45−/CD34+/CD31− progenitor subsets characterized by MSCA1 (ALPL) CD271 (NGFR) expression. MSCA1+ adipogenic subset enriched in stroma while contains mainly MSCA1−/CD271− MSCA1−/CD271 high progenitors. marks myofibroblast precursors NGF...
Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is a chronic inflammatory disease often accompanied by impairment of sense smell. This symptom has been somewhat overlooked, and its relationship to cytokines, tissue compression, neuronal loss, neurogenesis still unclear.In order elucidate potential mechanisms leading CRS in humans, we have established type 2/T helper 2 cell (Th2)-mediated allergic mouse model, based on house dust mite (HDM) Staphylococcus aureus enterotoxin B (SEB)...
KRASG12C is one of the most common mutations detected in non-small cell lung cancer (NSCLC) patients, and it a marker poor prognosis. The first FDA-approved inhibitors, sotorasib adagrasib, have been an enormous breakthrough for patients with mutant NSCLC; however, resistance to therapy emerging. transcriptional coactivators YAP1/TAZ family transcription factors TEAD1-4 are downstream effectors Hippo pathway regulate essential cellular processes such as proliferation survival. YAP1/TAZ-TEAD...
A patient with rheumatoid arthritis taking prednisone developed Blastocystis hominis acute diarrhoea, which was associated increased inflammation and effusion of the left knee. B organisms were found in synovial fluid from The responded dramatically to metronidazole treatment. may become disseminated immunosuppressed patients diarrhoea cause infective arthritis.
Abstract A simple and sensitive method adapted from the staining of living cells with fluorescein diacetate was developed to rapidly estimate number remaining in a culture dish 24 hr after few min NMDA treatment cerebellar neurons. This consists measurement, cell lysis, total amount produced by granule present each dish. We show that this can also be used quantify survival effect chronic exposure either K + or In both cases, fluorescence measured found proportional fluorescein‐labelled...
Nicotinic acetylcholine receptors (nAChRs), like other calcium permeable channel receptors, may play a crucial role during neuronal development. We have characterized nAChRs in developing mouse cerebellar granule cells primary culture. l[3H]Nicotine, [3H]cytisine and [125H]α-bungarotoxin binding experiments revealed the presence of single class saturable specific high affinity sites for each ligand. The expression these nicotinic followed developmental pattern reaching maximum establishment...
The neuromodulatory gene DISC1 is disrupted by a t(1;11) translocation that highly penetrant for schizophrenia and affective disorders, but how this affects function incompletely understood. N-methyl-D-aspartate receptors (NMDAR) play central role in synaptic plasticity cognition, are implicated the pathophysiology of through genetic functional studies. We show NMDAR subunit GluN2B complexes with DISC1-associated trafficking factor TRAK1, while interacts GluN1 regulates dendritic motility...
Background and Aims: To better understand nonalcoholic steatohepatitis (NASH) disease progression to evaluate drug targets compound activity, we undertook the development of an in vitro 3D model mimic liver architecture NASH environment.
Abstract This article critiques the “legal at time” argument used by states and companies which historically practised slavery to defend themselves against claims for restitution, examining Mauritian case. Although was largely legal there before its abolition British, torts were common under and, during years of historic rupture, 1794–1839, when local élite defied first French then English law, generated systemic unlawful activity. Most types action restitution face formidable difficulties;...
THE differential distribution of NMDA receptor subunit mRNAs in the developing mammalian cerebellum has been previously described. In this study, we investigated temporal expression proteins postnatal murine using antibodies specific for NMDAξ1 and NMDAε subunits. Our results showed a gradual increase during first three weeks life relative amount NMDAε;1 proteins. contrast, NMDAξ2 increased transiently period, reaching maximum around day 9 decreasing thereafter to nearly undetectable levels...
Abstract: Saturation experiments with the muscarinic antagonist [ 3 H] N ‐methylscopolamine ([ H]NMS) indicated that cerebellar granule cells in primary culture possess a high density of acetylcholine receptors (mAChRs): B max = 1.85 ± 0.01 pmol/mg protein at 10 days culture; K D 0.128 n M The selective 1 pirenzepine displaced H]NMS binding low affinity ( i 273 13 ), whereas 2 /M 4‐diphenylacetoxy‐ ‐methylpiperidine methiodide competed values nanomolar range, result suggesting some mAChRs on...
Où en est actuellement la concentration de l'Industrie française? Peut-on porter un jugement sur son évolution depuis le début du siècle et les tendances récentes ? On certes frappé par fort mouvement fusions des années récentes. Mais, à considérer chiffres disponibles jusqu'en 1964, on retient l'idée que « cristallisation système productif » demeure encore une caractéristique l'industrie française. La tendance plus notable persistante 1906 nos jours mortalité élevée petites unités...
Abstract The emergence of clustered regularly interspaced short palindromic repeats–Cas9 (CRISPR‐Cas9) gene editing systems has enabled the creation specific mutants at low cost, in a time and with high efficiency, eukaryotic cells. Since CRISPR‐Cas9 system typically creates an array mutations targeted sites, successful project requires careful selection edited clones. This process can be very challenging, especially when working multiallelic genes and/or polyploid cells (such as cancer...
The non-human primate (NHP)-brain endothelium constitutes an essential alternative to human in the prediction of molecule trafficking across blood-brain barrier (BBB). This study presents a comparison between NHP transcriptome freshly isolated brain microcapillaries and vitro-selected endothelial cells (BECs), focusing on important BBB features, namely tight junctions, receptors mediating transcytosis (RMT), ABC SLC transporters, given its relevance as model for identification new...