A5076472816- Inflammation biomarkers and pathways
- Autoimmune and Inflammatory Disorders Research
- Radiomics and Machine Learning in Medical Imaging
- Otitis Media and Relapsing Polychondritis
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- AI in cancer detection
- Cancer Immunotherapy and Biomarkers
- Kawasaki Disease and Coronary Complications
- Renal cell carcinoma treatment
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Sinusitis and nasal conditions
- CAR-T cell therapy research
- Oral and Maxillofacial Pathology
- Cancer Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Renal and related cancers
- Colorectal Cancer Screening and Detection
- Tumors and Oncological Cases
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Image Retrieval and Classification Techniques
- Effects of Radiation Exposure
Sanofi (France)
2018-2025
Institut Gustave Roussy
2019-2024
Inserm
2020-2023
Université Paris-Saclay
2020-2023
Laboratoire d'études sur les monothéismes
2022
Pitié-Salpêtrière Hospital
2016-2018
Sorbonne Université
2016-2018
Assistance Publique – Hôpitaux de Paris
2015-2018
Hôpital Lariboisière
2015-2017
Université Paris Cité
2015-2017
Aims Translocation renal cell carcinoma ( tRCC ) is a rare subtype of kidney tumour characterized by translocations involving the transcription factor TFE 3 or TFEB . was introduced into World Health Organization classification in 2004, but much still unknown about natural history, clinicopathological features and outcomes disease. The aim this study to describe landscape fusion transcript large single‐institution series fluorescence in‐situ hybridization FISH )‐confirmed s then compare it...
Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is a chronic inflammatory disease often accompanied by impairment of sense smell. This symptom has been somewhat overlooked, and its relationship to cytokines, tissue compression, neuronal loss, neurogenesis still unclear.In order elucidate potential mechanisms leading CRS in humans, we have established type 2/T helper 2 cell (Th2)-mediated allergic mouse model, based on house dust mite (HDM) Staphylococcus aureus enterotoxin B (SEB)...
Esthesioneuroblastoma (ENB) is a rare cancer of the olfactory mucosa, with no established molecular stratification to date. We report similarities ENB tumors arising in neural crest and perform integrative analysis these tumors. propose molecular-based subtype classification as basal or neural, both which have distinct pathological, transcriptomic, proteomic, immune features. Among subtype, we uncovered an IDH2 R172 mutant-enriched subgroup (∼35%) harboring CpG island methylator phenotype...
Background Transforming growth factor-beta (TGFβ) can limit the efficacy of cancer treatments, including radiotherapy (RT), by inducing an immunosuppressive tumor environment. The association TGFβ with impaired T cell infiltration and antitumor immunity is known, but mechanisms which participates in immune exclusion limits therapies warrant further investigations. Methods We used clinically relevant receptor 2 (TGFβR2)-neutralizing antibody MT1 small molecule TGFβR1 inhibitor LY3200882...
Chronic rhinosinusitis with nasal polyps (CRSwNP), asthma, and non-steroidal anti-inflammatory drug-exacerbated respiratory disease (NSAID-ERD) are frequent coexisting conditions share type 2 inflammatory pathophysiology, interleukin (IL)-4 IL-13 as key cytokines. Dupilumab is a monoclonal antibody that blocks the shared receptor for IL-4 IL-13. The objective of this analysis was to evaluate dupilumab's effect on inflammation biomarkers in patients CRSwNP with/without asthma or NSAID-ERD...
Abstract Patients with head and neck squamous cell carcinomas (HNSCC) often have poor outcomes due to suboptimal risk management treatment strategies; yet integrating novel prognostic biomarkers into clinical practice is challenging. Here, we report the presence of multinucleated giant cells (MGC)—a type macrophages—in tumors from patients HNSCC, which are associated a favorable prognosis in treatment-naive preoperative chemotherapy–treated patients. Importantly, MGC density increased...
Abstract Collecting duct carcinoma (CDC) is a kidney cancer subtype that thought to arise from principal cells in distal parts of the collecting ducts. Some studies suggested an overlap CDC with upper tract urothelial (UTUC), making pathological diagnosis challenging. Herein, we performed for first time transcriptome sequencing and compared them UTUC renal cell subtypes. We discovered displays unique transcriptomic signature among subtypes, putative origin convoluted tubules. Hierarchical...
Severe pneumonia and acute respiratory distress syndrome (ARDS) have been described in patients with severe coronavirus disease 2019 (COVID-19). Recently, early clinical data reported the feasibility of low doses radiation therapy (RT) treatment ARDS COVID-19. However, involved mechanisms remained unknown.Here, we used airways-instilled lipopolysaccharide (LPS) influenza virus (H1N1) as murine models pneumonia, toll-like receptor (TLR)-3 stimulation human lung macrophages.Low RT (0.5-1 Gray)...
Spatial transcriptomics (ST) enables the study of gene expression within its spatial context in histopathology samples. To date, a limiting factor has been resolution sequencing based ST products. The introduction Visium High Definition (HD) technology opens door to cell studies. However, challenges remain ability accurately map transcripts cells and assigning types on transcript data. We developed ENACT, self-contained pipeline that integrates advanced segmentation with HD data infer across...
Abstract Introduction: In digital pathology, extracting comprehensive data from a single tissue sample is critical for enhancing diagnostic precision and therapeutic strategies. Techniques like multiplex imaging spatial transcriptomics offer unprecedented depth of information. This study introduces novel innovative approach combining the first time Phenocycler® (with 34-marker panel) Visium® on same section squamous cell carcinoma upper aerodigestive tract. A was analyzed using (PP)...
Olfactory neuroblastomas (ONBs) are rare malignant tumours that arise in the nasal vault. To date, Hyams grade remains only widely used histological grading system. However, it is based on morphological criteria, and has not been updated since 1988. The objective of this study was to explore prognostic potential Ki67 proliferation index (PI) tumour-infiltrating lymphocytes (TILs) ONB.A retrospective conducted a bicentric series 45 cases. PI determined by counting at least 1000 nuclei whole...
In this study, a possible link between the innate immune recognition receptor TLR3 and metabolic reprogramming in Head Neck carcinoma (HNC) cells was investigated. The effects of stimulation/knock-down were assessed under several culture conditions 4 HNC cell-lines by cell growth assays, targeted metabolomics, glycolysis assays based on time-resolved analysis proton release (Seahorse analyzer). stimulation its synthetic agonist Poly(A:U) resulted faster low foetal calf serum conditions....
Sinonasal squamous cell carcinoma (SNSCC) is a rare and aggressive malignancy with poor prognosis. Human papilloma virus (HPV) can induce SNSCC although its incidence impact on patients’ outcomes remains unclear. We performed retrospective cohort study of patients treated consecutively in comprehensive cancer center. HPV status was determined p16 immunohistochemistry followed by RNA situ hybridization (RNAscope). The incidence, clinical characteristics, oncologic HPV+SNSCC were assessed. P16...
We reported a rare case of cutaneous metastases renal cell carcinoma (RCC) with an Xp11.2 translocation in 15-year-old female. Clinicians should be aware the possibility this uncommon site metastasis, which can indicate multivisceral dissemination disease. discuss feasibility and opportunity treating such patient multiple line tyrosine kinase inhibitor (TKI) targeting vascular endothelial platelet-derived growth factor receptors. Pediatr Blood Cancer 2014;61:1698–1700. © 2014 Wiley Periodicals, Inc.
There have been no studies to date of patterns events after oropharyngeal squamous cell carcinoma (OPC) treatment comprising disease progression immediately or a disease-free interval (DFI), and causes death, according HPV status.Patients with T1-4, N0-3, M0 OPC who completed in curative intent at our center between 2011 2020 were analyzed. A DFI was defined as the absence confirmed by both physical radiological evaluation.We analyzed 888 patients, 451 p16-positive 437 p16-negative. The...
Background Inverted papillomas (IP) inserted in the frontal sinus and/or recess may be treated by using an endoscopic endonasal or external approach. There are still few data available on this uncommon localization of IPs. Objective To report our experience management IP drainage pathway, to describe a previously unreported specific complication surgery, and discuss optimal surgical strategy. Methods A retrospective study patients at tertiary care center between 2004 2014 who were operated...
Sinonasal epithelial hamartomas occurring in adults are classified as seromucinous hamartoma (SMH) or respiratory adenomatoid (REAH). We describe herein a novel subtype of adult sinonasal that contains olfactory epithelium, histologic feature not previously reported the literature. Our pathology department database was retrospectively searched for containing areas epithelium. Six relevant cases (3 male and 3 female patients; age, 30 to 77 y) were retrieved, available slides clinical imaging...
Abstract Background The objective of our study was to investigate changes over the past decade in patient age and prevalence HPV population patients with oropharyngeal carcinoma (OPC) treated at center. Methods We performed a retrospective cohort cancer center for OPC between 2011 2021. Tissue biopsies were assessed status based on p16 staining all patients. Results There 1,365 proportion p16-positive increased from 43% 57.3% 2021 ( p = 0.01). sex ratio 3.6 M/1F 3.7 p16-negative 0.94). mean...
Abstract Severe pneumonia and acute respiratory distress syndrome (ARDS) have been described in patients with severe COVID-19. Recently, early clinical data reported the efficacy of low doses radiation therapy (RT) treatment ARDS However, involved mechanisms remained unknown. Here, we used airways-instilled lipopolysaccharide (LPS) influenza virus (H1N1) as murine models pneumonia, Tolllike receptor (TLR)-3 stimulation human lung macrophages. Low RT (0.5-1 Gy) decreased LPS induced increased...