A5049854116- Intraperitoneal and Appendiceal Malignancies
- Appendicitis Diagnosis and Management
- Ovarian cancer diagnosis and treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Head and Neck Cancer Studies
- Occupational and environmental lung diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Endometriosis Research and Treatment
- Oral and Maxillofacial Pathology
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Tumors and Oncological Cases
- Pancreatic and Hepatic Oncology Research
- Respiratory Support and Mechanisms
- Cardiac tumors and thrombi
- Pleural and Pulmonary Diseases
- Multiple Myeloma Research and Treatments
- Molecular Biology Techniques and Applications
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Omental and Epiploic Conditions
- Voice and Speech Disorders
Hôpital Lyon Sud
2019-2025
Hospices Civils de Lyon
2019-2025
Université Claude Bernard Lyon 1
2015-2025
Centre de Recherche en Cancérologie de Lyon
2021-2025
Université de Strasbourg
2024
Université de Montpellier
2024
Centre Hospitalier Universitaire de Montpellier
2024
Hôpital de la Croix-Rousse
2023
Lyon College
2023
The University of Texas MD Anderson Cancer Center
2022
Recurrent gene fusions are common in salivary gland tumors including benign tumors, such as pleomorphic adenoma (PA) and myoepithelioma (ME). In cases where chromosomal rearrangement is identified the 1 (PLAG1) gene, different partners found. Oncocytic metaplasia, characterized by oncocytes with abundant eosinophilic granular cytoplasm hyperchromatic nuclei, a well-known phenomenon neoplasms. However, pure oncocytic variant of PA/ME showed PLAG1 rearrangements involving various at molecular...
Abstract Background The incidence of gastric poorly cohesive carcinoma (PCC) is increasing. prognosis for patients with peritoneal metastases remains poor and the role cytoreductive surgery (CRS) hyperthermic intraperitoneal chemotherapy (HIPEC) controversial. aim was to clarify impact PCC treated by CRS or without HIPEC. Methods All from cancer HIPEC, in 19 French centres, between 1989 2014, were identified institutional databases. Clinicopathological characteristics outcomes compared...
Oropharyngeal squamous cell carcinomas (OPSCC) related to human papillomavirus (HPV) infection have a better prognosis than those without HPV infection. Although p16INK4a overexpression is used as surrogate marker for infection, 5-20% of p16-positive OPSCC are described being unrelated with worse overall survival compared OPSCC-related HPV. There therefore risk undertreating proportion patients falsely considered be HPV-driven because p16 positivity. TP53 mutations highly prevalent in driven...
Aims Salivary gland neoplasms (SGN) exhibiting the HMGA2 :: WIF1 fusion are recognized by their resemblance to histology found in canalicular adenoma. Recently, ~20% of cases among 28 ‐rearranged‐SGN showed malignancy and adverse outcomes (recurrence, distant metastasis, disease‐specific mortality). Among them, MDM2/CDK4 amplifications were identified one case. This outcome suggests that could be useful predict an aggressive course carcinoma ex‐pleomorphic adenoma (CEPA). Methods Results We...
Mesothelioma is a rare and aggressive malignant neoplasm arising from mesothelial cells, which occasionally manifests recurrent fusions. EWSR1/FUS-CREB, YY1, MAP3K8, NR4A3, ALK-rearranged proliferations have been reported in limited series with no clear histological or clinical correlations, limiting clinicians' ability to assess prognosis integrate these new entities into therapeutic decisions. The aim of this study was better characterize rearranged histologically, molecularly, clinically....
Abstract Background Ovarian pseudomyxoma peritonei (OPMP) are rare, without well-defined therapeutic guidelines. We aimed to evaluate cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) treat OPMP. Methods Patients from the French National Network for Rare Peritoneal Tumors (RENAPE) database with proven OPMP treated by CRS/HIPEC histologically normal appendix digestive endoscopy were retrospectively included. Clinical follow-up data collected. Histopathological...
// Nazim Benzerdjeb 1, 2 , Henri Sevestre Ahmed Ahidouch 2, 3 Halima Ouadid-Ahidouch 1 Laboratory of Cellular and Molecular Physiology, LPCM: EA 4667, SFR CAP-SANTE (FED 4231), UFR Sciences, Amiens, France Department Pathology, Amiens University Hospital, Biology, Ibn Zohr University, Agadir, Morocco Correspondence to: Ouadid-Ahidouch, email: halima.ahidouch-ouadid@u-picardie.fr Benzerdjeb, nazim.benz@gmail.com Keywords: orai3, lung adenocarcinoma, prognostic marker, survival Received: June...
Aims The peritoneal regression grading score (PRGS) and cytology (PC) assess response to chemotherapy in metastasis (PM) a setting of palliative treatment by pressurized intraperitoneal aerosol (PIPAC). Progression has been defined as an increase PRGS between first third PIPAC procedures (iPRGS). iPRGSand positive were not associated with prognostic impact. These results may be explained lack statistical power. Also, it is known whether the mean or highest among taken biopsies bears clinical...
Programmed death-ligand 1 (PD-L1) is the most validated predictive biomarker used for treatment of head and neck squamous cell carcinoma (HNSCC) with immune checkpoint inhibitors (ICI). Several gene expression-based signatures surrogate activation IFN-gamma pathway presence tertiary lymphoid structures (TLS) have also been proposed as potential biomarkers. While they may a therapeutic implication, longitudinal changes either PD-L1 or expression profiles between initial recurrent HNSCC...
Non‐small cell lung cancer (NSCLC) affects 10–50% of patients with epidermal growth factor receptor ( EGFR ) mutations. Osimertinib is a third‐generation tyrosine kinase inhibitor (TKI) that radically changes the outcome tumors bearing sensitizing or T790M resistance However, usually occurs, and new therapeutic combinations need to be explored. The chorioallantoic membrane (CAM) xenograft model ideal for studying aggressive tumor responses complex due its vascularization microenvironment....
High-grade appendiceal mucinous neoplasm (HAMN) is used to describe a rare epithelial of the appendix characterized by pushing-type invasion and high-grade cytologic atypia. Its implications regarding lymph node spread necessity right colectomy are currently debate. The objective present study was assess clinicopathologic characteristics, risk peritoneal metastasis, long-term outcomes patients diagnosed as HAMN in comparison low-grade (LAMN) adenocarcinoma, treated hemicolectomy. A total 443...
<title>Abstract</title> Peritoneal mesothelioma (PM) is a rare aggressive cancer with limited treatment options upon progression. Genomic profiling European (Arcagen cohort) and French (AURAGEN initiatives aim to guide treatments for cancers. This study presents the initial findings from these efforts. Molecular analysis (n = 56, 55.4% females, mean 55.9 years) showed high success rate identify clinically relevant mutations; majority of patients harbored <italic>BAP1</italic>,...
Objective Structured Clinical Examinations (OSCE) are an essential component of the reform second cycle medical studies in France, aiming to reliably and objectively assess students' clinical skills. We propose tools develop scenarios adapted pathology, allowing evaluation ability interpret histopathological reports, integrate these results into management, communicate pathology findings clearly understandably patients. The article also presents a practical application OSCE hospital setting:...
Background To investigate the effect of intraductal carcinoma prostate (IDC‐P) in radical prostatectomy (RP) specimens context site recurrence, time to and cancer‐specific survival two academic cohorts locally, regionally, or distantly recurrent cancer. Methods Our cohort included men enrolled into tissue repositories from 1993 2011, who were treated with first‐line RP later experienced local regional distant metastasis (together termed clinical CR). material was reviewed identify IDC‐P...
Prostate cancer (PC) is the most frequently diagnosed in North American men. Pathologists are critical need of accurate biomarkers to characterize PC, particularly confirm presence intraductal carcinoma prostate (IDC-P), an aggressive histopathological variant for which therapeutic options now available. Our aim was identify IDC-P with Raman micro-spectroscopy (RμS) and machine learning technology following a protocol suitable routine clinical histopathology laboratories.
Abstract Aim The peritoneal cancer index (PCI) is one of the strongest prognostic factors in patients undergoing cytoreductive surgery (CRS) for colorectal metastases. Using pathological evaluation, however, disease extent differs a large proportion patients. Our aim was to study correlation between radiological (rPCI), surgical (sPCI) and (pPCI) PCI order determine affecting discordance these indices their potential therapeutic implications. Method From July 2018 December 2019, 128 were...
The liquid-based cytology Papanicolaou (Pap) test has gradually replaced the conventional Pap test, as it seems to be more efficient, in part because uses computer assistance. However, diagnoses are still subjective and cost-consuming or time-consuming. authors describe a new digital holographic microscopy instrument accompanying software. This technology provides an instantaneous, 3-dimensional image reconstruction of cells directly from uterine cervical sample vial.Analyses were performed...