A5083974898- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Intraperitoneal and Appendiceal Malignancies
- Cancer Treatment and Pharmacology
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Occupational and environmental lung diseases
- Advanced Breast Cancer Therapies
- Ferroptosis and cancer prognosis
- Appendicitis Diagnosis and Management
- Monoclonal and Polyclonal Antibodies Research
- Breast Lesions and Carcinomas
- Advanced Proteomics Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Mass Spectrometry Techniques and Applications
- Colorectal and Anal Carcinomas
- Diagnosis and treatment of tuberculosis
- RNA Research and Splicing
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Colorectal Cancer Surgical Treatments
- RNA and protein synthesis mechanisms
Institut de Cancérologie de l'Ouest
2015-2024
UniCancer Group
2021
Inserm
2015-2020
Université d'Angers
2019-2020
Institut Claudius Regaud
2005-2019
Centre Jean Perrin
2009-2019
Institut Bergonié
2013-2019
Centre Léon Bérard
2013-2019
Institut Curie
2013-2019
Centre Antoine Lacassagne
2019
Triple-negative breast cancers need to be refined in order identify therapeutic subgroups of patients.We conducted an unsupervised analysis microarray gene-expression profiles 107 triple-negative cancer patients and undertook robust functional annotation the molecular entities found by means numerous approaches including immunohistochemistry signatures. A external cohort (n=87) was used for validation.Fuzzy clustering separated tumours into three clusters: C1 (22.4%), C2 (44.9%) C3 (32.7%)....
Purpose The indications of adjuvant chemotherapy for patients with estrogen receptor (ER) –positive breast cancer are controversial. We analyzed the predictive value Ki67, HER2, and progesterone (PR) expression efficacy docetaxel in ER-positive, node-positive cancer. Patients Methods Expression PR was measured by immunohistochemistry tumor samples from 798 ER-positive who participated PACS01, a randomized trial that evaluated docetaxel. Risk reduction using Cox model adjusted age, size,...
Heterogeneity and lack of targeted therapies represent the two main impediments to precision treatment triple-negative breast cancer (TNBC), therefore, molecular subtyping identification therapeutic pathways are required optimize medical care. The aim present study was define robust TNBC subtypes with clinical relevance. Gene expression profiling by means DNA chips conducted in an internal cohort composed 238 patients. In addition, external data (n = 257), obtained using same chip, were used...
Expression of hormone receptor (HR) for estrogens (ER) and progesterone (PR) HER2 remains the cornerstone to define therapeutic strategy breast cancer patients. We aimed compare phenotypic profiles between matched primary metastatic (MBC) in ESME database, a National real-life multicenter cohort MBC Patients with results available on both tumour disease within 6 months diagnosis before any progression were eligible main analysis. Among 16,703 patients included 1677 (10.0%) had biopsy at...
Abstract Senescence is a tumor-suppressive mechanism induced by telomere shortening, oncogenes, or chemotherapy treatment. Although it clear that this suppressive pathway leads to permanent arrest in primary cells, might not be the case cancer cells have inactivated their pathways. We recently shown subpopulations of can escape chemotherapy-mediated senescence and emerge as more transformed induce tumor formation, resist anoikis, are invasive. In study, we characterized emergence showed...
To date, there is no available targeted therapy for patients who are diagnosed with triple-negative breast cancers (TNBC). The aim of this study was to identify a new specific target treatments. Frozen primary tumors were collected from 83 adjuvant therapy-naive TNBC patients. These samples used global proteome profiling by iTRAQ-OFFGEL-LC-MS/MS approach in two series: training cohort (n = 42) and test set 41). Patients remains free local or distant metastasis minimum 5 years after surgery...
Mesothelioma is a rare and aggressive malignant neoplasm arising from mesothelial cells, which occasionally manifests recurrent fusions. EWSR1/FUS-CREB, YY1, MAP3K8, NR4A3, ALK-rearranged proliferations have been reported in limited series with no clear histological or clinical correlations, limiting clinicians' ability to assess prognosis integrate these new entities into therapeutic decisions. The aim of this study was better characterize rearranged histologically, molecularly, clinically....
High-grade appendiceal mucinous neoplasm (HAMN) is used to describe a rare epithelial of the appendix characterized by pushing-type invasion and high-grade cytologic atypia. Its implications regarding lymph node spread necessity right colectomy are currently debate. The objective present study was assess clinicopathologic characteristics, risk peritoneal metastasis, long-term outcomes patients diagnosed as HAMN in comparison low-grade (LAMN) adenocarcinoma, treated hemicolectomy. A total 443...
Abstract Human olfactomedin‐4 (OLFM4) is a secreted protein involved in variety of cellular functions including proliferation, differentiation, apoptosis, and cell adhesion. OLFM4 expression has been studied several tumor types gastric, colorectal, lung, endometrioid cancers where it suggested to be an independent favorable or unfavorable prognostic marker. For breast cancer, the clinical significance still unclear. In present study, SWATH‐MS used as tool for robust identification...
Peritoneal carcinomatosis (PC) is associated with a very poor prognosis. Complete cytoreductive surgery combined hyperthermic intraperitoneal chemotherapy has been shown to improve survival rates of PC. However, this treatment beneficial for patients if the complete macroscopically completed before implementing chemotherapy. Even so, strict selection fundamental importance because invasive nature intervention. The aim study was assess performance FDG-PET/CT examinations diagnosis and...
We performed biopsies during reoperation for minor complications in two active young patients 9 and 19 months after massive bone allograft implantation tumour. The grafts were dead resorption-apposition activity, when present, was predominantly subperiosteal areas. Inflammatory infiltration very seldom found. Features considered as ‘microfractures’ or ‘microcracks’ noted the cortical ring together with formation of woven bone, areas remodelling. Such cracks are likely to be mechanical origin...
The aim of the study was to assess sensitivity and specificity fluorescence immunocytochemistry (uCyt+ assay) as combined with urinary cytology for detection primary recurrent urothelial carcinomas. We analyzed 694 samples from 236 new symptomatic patients 458 followed after transurethral resection (TUR) bladder tumor. Lesions suspicious cancer at cystoscopy were sampled by biopsies or TUR. Sensitivity tests calculated using histopathology, whether not gold standards. In patients, uCyt+ 40%,...
Recent findings suggest that S100A4, a protein involved in communication between stromal cells and cancer cells, could be more than previously expected invasiveness. To investigate its cumulative value the multistep process of pathogenesis malignant mesothelioma (MM), SWATH-MS (sequential window acquisition all theoretical fragmentation spectra), an advanced robust technique quantitative proteomics, was used to analyze collection 26 preneoplastic neoplastic rat mesothelial cell lines models...
Linitis plastica of the stomach was diagnosed in four patients. Endoscopic ultrasonography (EUS) performed cases; they were monitored by EUS and had their treatment adapted accordingly. According to present study, typical criteria gastric linitis at are: (a) rigidity wall; (b) a wall thickness exceeding 6 mm; (c) second enlarged layer marginally more echogenic than fourth hypoechogenic (muscularis propria); (d) third hyperechogenic layer; (e) poor demarcation between layers. Gastric appears...
The Centre de Ressources Biologiques-Tumorothèque ICO is a biobank integrated in clinical cancer center (ICO, Institut Cancérologie l'Ouest, Saint-Herblain, FR) that collects tissues (snap frozen, FFPE, TMA) and biological (serum, plasma, DNA, RNA, stools, etc) samples from oncology patients dedicated to translational research. started its activities 2002 certified NF S 96 900. Activities are framed by quality management system with established validated SOPs for all work procedures. Samples...