A5004751571- Cancer and Skin Lesions
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Nonmelanoma Skin Cancer Studies
- Lung Cancer Research Studies
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Polyomavirus and related diseases
- Ear and Head Tumors
- Pituitary Gland Disorders and Treatments
- Hedgehog Signaling Pathway Studies
- Soft tissue tumor case studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Medical Imaging and Pathology Studies
- Lung Cancer Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Cancer Immunotherapy and Biomarkers
- Aortic Disease and Treatment Approaches
- Skin and Cellular Biology Research
- Tumors and Oncological Cases
- Eosinophilic Disorders and Syndromes
Oita University
2016-2025
Oita University Hospital
2017-2025
DNA Diagnostic (Denmark)
2025
Tokyo Metropolitan Hiroo Hospital
1984
Advanced colorectal cancer harbors extensive intratumor heterogeneity shaped by neutral evolution; however, in precancerous lesions has been poorly studied. We perform multiregion whole-exome sequencing on ten early tumors, which contained adenoma and carcinoma situ. By comparing with data from advanced we show that the tumors accumulate a higher proportion of subclonal driver mutations than is highlighted KRAS APC. also demonstrate variant allele frequencies tend to be suggesting are...
Extramammary Paget disease (EMPD) is a rare skin cancer that typically occurs in the anogenital area of older people. Since efficacy treatments for metastatic or unresectable EMPD remains poor, development novel therapeutic approach strongly desired. However, lack models has hampered investigation EMPD. Here we investigated whether trophoblast cell surface antigen 2 (TROP2) could be promising target We retrospectively collected 108 samples from 54 patients with primary and 10 Japanese...
Testicular metastasis of a renal cell carcinoma (RCC) is extremely rare, particularly in the initial clinical presentation. Herein, we describe unique case which small mass (pT1a RCC) initially manifested as contralateral testicular metastasis. A 64-year-old man presented with right intrascrotal mass. Radiology revealed multiple enlarged retroperitoneal lymph nodes and an 18-mm left kidney. Following orchidectomy, tumor was pathologically not origin but Subsequently, patient underwent...
Pancreatic ductal adenocarcinoma (PDA) of the head (hPDA) is more frequently diagnosed than PDA body/tail (btPDA) due to prevalent biliary obstruction symptoms, such as jaundice. hPDA and treated at an earlier stage btPDA, leading improved prognosis. Data from 60 patients with (30 30 btPDA) were analyzed, investigating tumor location (hPDA/btPDA) clinical information [tumor size, lymph node metastasis, overall survival (OS)] depending on histological patterns [large duct pattern (PDA-L)...
Lanthanum carbonate (LaC) is used to prevent hyperphosphatemia in dialysis patients. It commonly believed that there little LaC absorption from the intestines. However, La deposition gastric mucosa, which we coined “gastric lanthanosis”, was recently reported. We describe here clinicopathological features of and a possible mechanism for lanthanosis. This study included 23 patients with definite extracted characteristic lanthanosis by computed tomography (CT) imaging endoscopic, histologic,...
Abstract Primary large‐cell neuroendocrine carcinoma of the endometrium is extremely rare and has a poor prognosis. This report describes case combined endometrioid adenocarcinoma diagnosed as stage IIIA. The patient underwent surgery chemotherapy been well with no evidence disease for 20 months. optimal treatment this tumor not established. Considering its rarity variability, it difficult to establish an evidence‐based therapeutic regimen.
KIT (CD117, c-kit) is a receptor tyrosine kinase involved in the tumorigenesis of several neoplasms. expressed by secretory cells normal sweat glands. We studied expression and mutational status various benign malignant tumors eccrine apocrine included total 108 cases comprising 10 6 gland tumors, was immunohistochemically detected (positive rate): syringomas (0%), 8 poromas (25%), 20 mixed (40%), 21 spiradenomas (43%), 1 cylindroma 5 hidradenomas 7 syringocystadenoma papilliferum papillary...
Ovarian mature teratomas (OMTs) originate from post-meiotic germ cells. Malignant transformation occurs in approximately 1-2% of OMTs; however, sebaceous carcinoma arising OMTs is rare. This the first report a detailed genomic analysis an OMT. A 36-year-old woman underwent evaluation for abdominal tumors and subsequent hysterectomy salpingo-oophorectomy. Pathologically, diagnosis stage IA OMT was established. Eight months post-surgery, patient alive without recurrence. Immunohistochemically,...
Abstract Pemetrexed, which is used for the treatment of non‐small cell lung carcinoma and malignant mesothelioma, induces cutaneous adverse reactions in approximately 20% patients. There are also reports induction fibrosing disorders. We describe a case pemetrexed‐induced scleroderma‐like conditions lower legs patient whose pulmonary has been relatively well controlled, with prolongation dose interval, spite discomfort both his legs. Skin biopsy revealed dermal fibrosis dilated lymph vessels...
Abstract OBJECTIVES Aortic valve neocuspidization has shown satisfactory clinical outcomes; however, autologous pericardium durability is a concern for young patients. This study applied an collagenous membrane (Biosheet®), produced by in-body tissue architecture, to aortic and investigated its long-term outcome in goat model. METHODS Moulds were embedded subcutaneously 6 goats. After 2 months, Biosheets formed the moulds. We performed using portion of sheets with thickness 0.20–0.35 mm,...
Coronavirus disease 2019 (COVID-19) has spread worldwide. Vaccination is now recommended as one of the effective countermeasures to control pandemic or prevent worsening symptoms. However, its adverse effects have been attracting attention. Here, we report an autopsy case multiple thromboses after receiving first dose BNT162b2 mRNA vaccine (Comirnaty, Pfizer/BioNTech) in elderly woman.A 72-year-old woman with a history diffuse large B-cell lymphoma stomach and hyperthyroidism received died 2...
We report a case of ALK‐positive renal cell carcinoma coincident with Hodgkin lymphoma. The patient was 19 year‐old‐girl without sickle trait. right tumor discovered concomitantly lymphoma (HL). After chemotherapy for HL, nephrectomy performed. Microscopically, the showed solid and focally pseudo‐papillary growth pattern studded tubular structures. Most cells were small bland eosinophilic cells, but rhabdoid vacuolated pleomorphic multinucleated giant also admixed. variety patterns features...
A 73-year-old Japanese woman presented with cutaneous horn on the right cheek. The resected tumor was 9 mm in diameter, 14 protrusion, and showed exophytic growth marked papillomatosis. Histopathology proliferation of atypical melanocytes melanin pigments epidermis dermis under horn. These cells were confined to base horn, did not spread surrounding epidermis. final diagnosis malignant melanoma. This pathological entity is considered a specific form verrucous melanoma, might be added list...
NKX3.1, a transcription factor related to androgen expression, has recently been introduced as diagnostic marker of prostate adenocarcinoma. Salivary duct carcinoma (SDC) is typically positive for receptor (AR). Therefore, we hypothesized that NKX3.1 new immunohistochemical SDC and aimed investigate whether staining in combination with other immunomarkers could have or prognostic value SDC.Materials obtained from 42 resected SDCs were examined by immunohistochemistry using antibodies against...
Abstract A Japanese male in his 30s with no underlying medical condition presented painless nodules after being bitten by a dog during stay Bali, Indonesia, 7 years earlier. He was referred to our department multiple ulcers, nodules, and masses on the right leg. The final diagnosis mycetoma caused Nocardia vulneris , which may have been exacerbated colonization of Candida parapsilosis C. tropicalis as these yeasts were isolated culture from tissue. Treatment minocycline hydrochloride...
The identification and analysis of lipid droplets in pathological images are pivotal owing to the variations their size, shading shape. development an artificial intelligence-based automatic detection method can facilitate complex provide essential support pathologists. In this paper, we introduce a novel approach for automated droplets, employing limited set modest application reinforcement learning (RL). Several filters tailored droplet size contrast used combination. Through combination...
Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare, aggressive tumor that primarily affects young females. It monogenic disorder caused by germline and/or somatic SWI/SNF-related, matrix-associated, actin-dependent regulator chromatin, subfamily a, member 4 (SMARCA4) mutations. Here, we report case SCCOHT harboring multiple previously unreported mutations in SMARCA4 (c.2866_2867delC>T; c.3543del). A 28-year-old breastfeeding Japanese female presented to previous...
Breast cancer (BC) is classified into four major histological subtypes, namely luminal A, B, HER2, and basal-like, its treatment based on these subtypes. The use of immune checkpoint inhibitors against BC depends the expression PD-1/PD-L1. Another tumor system-the cGAS-STING pathway-is a potential target for immunotherapy. However, status pathway in has not been fully established. Therefore, we investigated immune-related proteins BC. We 111 BCs six groups-29 hormone receptor-positive...