A5102892040- Thyroid Cancer Diagnosis and Treatment
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Neuroendocrine Tumor Research Advances
- IgG4-Related and Inflammatory Diseases
- Systemic Lupus Erythematosus Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Cancer-related Molecular Pathways
- Monoclonal and Polyclonal Antibodies Research
- Helicobacter pylori-related gastroenterology studies
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gut microbiota and health
- Intracranial Aneurysms: Treatment and Complications
- Cell death mechanisms and regulation
- Gestational Diabetes Research and Management
- Genetic and Kidney Cyst Diseases
- Esophageal and GI Pathology
- Biomarkers in Disease Mechanisms
Oita University
2015-2025
Aomori Prefectural Central Hospital
2024
Kinan Hospital
2014-2023
Mito Saiseikai General Hospital
2022
Kansai Medical University
2005-2020
Wakayama Medical University
2003-2017
National Center for Global Health and Medicine
2012-2014
Center for Global Health
2013
Hirosaki National Hospital
2012
Hirosaki University Hospital
1992-2010
1 We have investigated the effects of moderate global undernutrition during gestation in rat on blood pressure male and female offspring, development systemic vascular function. Pregnant Wistar rats were nutritionally restricted (R) by feeding with 70% normal gestation-matched dietary intake from 0 to 18 days gestation. 2 R offspring growth retarded at birth but similar weight controls (C) 20 days. Systolic and/or diastolic mean arterial pressures, measured directly femoral artery catheter,...
IgG4‐related sclerosing disease has been recently recognized as a systemic entity characterized by an elevated serum IgG4 level, fibrosis and diffuse lymphoplasmacytic infiltration many IgG4‐positive plasma cells. Similar histopathological features have often noted in the fibrous variant of Hashimoto's autoimmune thyroiditis, but thyroid gland involvement only briefly mentioned with regard to IgG4, no immunohistochemistry for reported thyroiditis. Herein, purpose present study was...
There is a continuous debate regarding the classification of thyroid follicular lesions and term “well‐differentiated tumor uncertain malignant potential (WDT‐UMP)” was recently introduced to cover this problematic spectrum tumors. The objective study reappraise WDT‐UMP using morphological, immunochemical, molecular analysis shed more light on encapsulated follicular‐patterned A total 30 cases with equivocal papillary carcinoma‐type nuclear changes (PTC‐N) or focal unequivocal PTC‐N were...
Recent reports on Hashimoto's thyroiditis (HT) with increased numbers of IgG4-positive plasma cells suggest that this type HT may have a close relationship to IgG4-related disease (IgG4-RD). This unique subgroup is termed as IgG4 and reveals distinct clinical, serological, sonographic features from the non-IgG4 group. On basis immunostaining for IgG4, was divided into an group Clinically, associated younger age group, lower female-male ratio, higher levels thyroid autoantibodies, diffuse low...
To study the regulation of ductus venosus (DV) inlet in vivo, we measured effect vasoactive substances and hypoxemia on its diameter nine fetal sheep utero at 0.9 gestation under ketamine-diazepam anesthesia. Catheters were inserted into an umbilical vein a common carotid artery, flowmeter was placed around veins. Ultrasound measurements DV during normoxic baseline conditions [fetal arterial Po 2 (Pao ) 24 mmHg] compared with infusion sodium nitroprusside (SNP; 1.3, 2.6, 6.5 μg · kg −1 min...
Endothelial cells of the cerebral arterial system in spontaneously hypertensive rats were investigated by scanning electronmicroscopy and found to show progressive changes such as increased microvilli, numerous plasmalemmal pits, enlargement well-developed marginal folds. Regressive changes, balloon-like protrusions crater-like cave-ins, also observed. Platelet adhesion injured endothelial surface arteries was frequent. The significance these development cerebrovascular lesions is discussed.
Two hundred and sixty‐three cases of primary human papillary thyroid carcinoma (PTC) were analyzed. All met the following parameters: tumor size ≥ 10 mm, no distant metastasis at presentation, coexistence other histological type. The features solid/trabecular component, encapsulation, tall/columnar cell component loss polarity/cohesiveness utilized to subclassify 263 PTC into five groups: solid type (15.6%), encapsulated group (9.5%), (7.2%), micropapillary/discohesive (19.8%)...
In anesthetized dogs, subarachnoid hemorrhage (SAH) was induced by the mechanical rupture of unilateral intracranial internal carotid artery. Vasospasm angiographically determined 24 hours and 7 days after SAH. Contractile responses to serotonin, norepinephrine, histamine, K+ were compared in control bleeding sides middle cerebral arteries removed from dogs with SAH, sham-operated dogs. Under sham operation 2 both did not appreciably differ but response significantly less side as hemorrhage....
Carcinoma of possible thymic epithelial origin may occur within the thyroid gland, which was first reported by Miyauchi et al. as intrathyroid thymoma (ITET). ITET is a rare tumor comprising about 0.08% all primary malignancies. It low-grade carcinoma with squamous cell differentiation whose overall survival rate found to be 71%. Lymph node metastasis at surgery in 40% and hematogenous metastases developed bones, liver lungs. This grows gland invades into parenchyma well extrathyroid...
Background Loss of cellular polarity/cohesiveness (LOP/C) in the invasive front papillary thyroid carcinoma (PTC) results a high recurrence risk PTC. Aims To investigate immunohistochemical features LOP/C PTC and to show that this feature is linked association lymph node metastasis (LNM) at surgery tumour recurrence. Methods The degree PTCs was evaluated histologically using cut-off value 20% were analysed staining for E-cadherin, β-catenin vimentin. relationship between other...
Human epidemiological and animal experimental studies suggest that maternal undernutrition during pregnancy may alter cardiovascular development of the offspring. The extent to which these effects involve changes in fetal function whether they are necessarily linked reduced growth is unknown. In sheep, we investigated effect a 15% reduction global nutrition for first 70 days gestation (term = 147 days) on blood pressure development, baroreflex control heart rate (FHR), responses acute...
The fetal hypothalamic-pituitary-adrenal (HPA) axis has numerous key roles in development. Epidemiological data have linked adverse prenatal nutrition with altered organ development and increased incidence of disease adult life. We studied HPA resting stimulated states late gestation sheep, following 15% reduction maternal nutritional intake over the first 70 days (dGA). Fetuses from control (C) nutrient-restricted (R) ewes were chronically catheterised response profiles for ACTH cortisol...
Insulin-like growth factor (IGF) 1 has protective effects in liver failure. However, the effect of IGF-1 on inflammatory mediators such as proinflammatory cytokines and NO remains to be clarified. We hypothesized that inhibited induction these iNOS, resulting beneficial liver. Rats were treated with D-galactosamine (400 mg kg(-1)) LPS (16 microg (GalN/LPS) induce acute (3.2 was administered subcutaneously before GalN/LPS injection. increased survival rate GalN/LPS-treated rats prevented...
Although having the capacity to grow in response a stimulus that perturbs pituitary-thyroid axis, thyroid gland is considered not regenerative organ. In this study, partial thyroidectomy (PTx) was used produce condition for regeneration. intact gland, central areas of both lobes served as proliferative centers where microfollicles, and bromodeoxyuridine (BrdU)-positive and/or C cells, were localized. Two weeks after PTx, number BrdU-positive cells with clear or faintly eosinophilic cytoplasm...
Journal Article Successful tocilizumab therapy in seven patients with refractory adult-onset Still's disease Get access Ei Bannai, Bannai Division of Rheumatic Diseases, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan Search other works by this author on: Oxford Academic Google Scholar Hiroyuki Yamashita, Yamashita Correspondence to: 1-21-1 Toyama, Shinjuku, Tokyo 162-8655, Japan. Tel: + 81-3-3202-7181. Fax: 81-3-3207-1038. E-mail: hiroyuki_yjp2005@yahoo.co.jp...
Idiopathic multicentric Castleman disease (iMCD) accompanied by thrombocytopenia, anasarca, fever, reticulin myelofibrosis/renal insufficiency, and organomegaly (TAFRO) frequently develops into prolonged severe thrombocytopenia multiorgan dysfunction, which is associated with a high mortality rate. We herein describe three cases of iMCD-TAFRO in serum soluble interleukin-2 receptor (sIL-2R) levels varied relation to activity following the initiation treatment. Thrombocytopenia persisted for...