A5034075082- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Protein Structure and Dynamics
- Machine Learning in Bioinformatics
- Medical Imaging Techniques and Applications
- RNA Research and Splicing
- RNA modifications and cancer
- Cellular transport and secretion
- Genomics and Chromatin Dynamics
- Metastasis and carcinoma case studies
- Glycosylation and Glycoproteins Research
- Bacterial Genetics and Biotechnology
- MRI in cancer diagnosis
- Lymphoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Endoplasmic Reticulum Stress and Disease
- Marine and coastal ecosystems
- Plant Reproductive Biology
- Molecular Biology Techniques and Applications
- Gastrointestinal disorders and treatments
- Breast Implant and Reconstruction
- Protist diversity and phylogeny
- CNS Lymphoma Diagnosis and Treatment
Maebashi Institute of Technology
2008-2024
Niigata Cancer Center Hospital
2010-2021
Obayashi (Japan)
2018
University of Massachusetts Chan Medical School
2018
Bank of Japan
2002-2012
National Institute of Genetics
2002-2012
Kameda Medical Center
2011
Research Organization of Information and Systems
2004-2011
Teikyo University
2011
Dokkyo University
2011
The human genome sequence defines our inherent biological potential; the realization of biology encoded therein requires knowledge function each gene. Currently, in this area is still limited. Several lines investigation have been used to elucidate structure and genes genome. Even so, gene prediction remains a difficult task, as varieties transcripts may vary great extent. We thus performed an exhaustive integrative characterization 41,118 full-length cDNAs that capture complete functional...
Phosphatidylinositol 4,5-biphosphate (PtdIns(4,5)P2), an important element in eukaryotic signal transduction, is synthesized either by phosphatidylinositol-4-phosphate 5-kinase (PtdIns(4)P 5K) from phosphatidylinositol 4-phosphate (PtdIns(4)P) or phosphatidylinositol-5-phosphate 4-kinase (PtdIns(5)P 4K) 5-phosphate (PtdIns(5)P). Two Saccharomyces cerevisiae genes, MSS4 and FAB1, are homologous to mammalian PtdIns(4)P 5Ks PtdIns(5)P 4Ks. We show here that a functional homolog of 5K but not 4K...
Autophagy is a process of self-digestion generally observed in eukaryotes and has been shown to play crucial roles for survival under starvation removal deleterious substances. Despite great advances that have made, many problems mechanisms autophagy remain unsolved. As large number autophagy-related proteins are identified each species, database collects data, identifies their homologs other species makes them available will contribute research advancement. no such resources exist, we built...
IVL is characterized by a propensity for intravascular tumor cell proliferation. Premortem diagnosis of difficult because its nonspecific clinical, laboratory, and imaging manifestations. This study examined cerebral MR patterns their changes with without chemotherapy. Nine 11 patients studied presented abnormal findings. We define 5 findings: 1) infarctlike lesions, 2) white matter 3) meningeal enhancement, 4) masslike 5) hyperintense lesions in the pons on T2WI. Seven only 1 pattern, while...
Although structural domains in proteins (SDs) are important, half of the regions human proteome currently left with no SD assignments. These unassigned consist not only novel SDs, but also intrinsically disordered (ID) since proteins, especially those eukaryotes, generally contain a significant fraction ID regions. As can be inferred from amino acid sequences, method that combines and region assignments determine fractions SDs any proteome.In contrast to other available prediction programs...
ABSTRACT We sequenced the genome of Theileria orientalis , a tick-borne apicomplexan protozoan parasite cattle. The focus this study was comparative analysis T . relative to other highly pathogenic species, parva and annulata induce transformation infected cells lymphocyte or macrophage/monocyte lineages; in contrast, does not uncontrolled proliferation leukocytes multiplies predominantly within erythrocytes. While synteny across homologous chromosomes three species found be well conserved...
O-glycosylation of mammalian proteins is one the important posttranslational modifications. We applied a support vector machine (SVM) to predict whether Ser or Thr glycosylated, in order elucidate mechanism. O-glycosylated sites were often found clustered along sequence, whereas other located sporadically. Therefore, we developed two types SVMs for predicting and isolated separately. that amino acid composition was effective type, site-specific algorithm type. The highest prediction accuracy...
We present two cases of ciliated muconodular papillary tumour (CMPT) in this report. CMPT is a newly defined low-grade malignant with columnar epithelial cells, occurring the peripheral lung. Both patients underwent pulmonary resection due to an enlarged solitary nodule. Pathological findings both confirmed mixture and goblet cells. The tumours were rich mucous had spread along alveolar walls, as observed bronchioloalveolar carcinoma. Nuclear atypia was mild, no mitotic activity observed....
Abstract Molecular characteristics of carcinoma arising from mature cystic teratoma the ovary (MCT) remain unclear due to its rarity. We analyzed RNA-sequencing data 2322 pan-cancer [1378 squamous cell carcinomas (SCC), 6 adenosquamous (ASC), and 938 adenocarcinomas (AC)] including six MCT (four SCCs, one ASC, AC). Hierarchical clustering principal component analysis showed that gene expression profiles were different between each histological type SCCs (MCT-SCCs) was apparently similar...
Abstract BACKGROUND: The objective of this study was to confirm, by means a multicenter conducted in Japan, the reliability and usefulness one‐step nucleic acid amplification (OSNA) assay routine clinical use for sentinel lymph node biopsy (SLNB) breast cancer patients. METHODS: Patients with Tis‐T2N0M0 who underwent SLNB before systemic chemotherapy comprised cohort. A whole (SLN) examined intraoperatively OSNA except 1‐mm‐thick, central slice node, which pathologic examination after...
Carcinoma of possible thymic epithelial origin may occur within the thyroid gland, which was first reported by Miyauchi et al. as intrathyroid thymoma (ITET). ITET is a rare tumor comprising about 0.08% all primary malignancies. It low-grade carcinoma with squamous cell differentiation whose overall survival rate found to be 71%. Lymph node metastasis at surgery in 40% and hematogenous metastases developed bones, liver lungs. This grows gland invades into parenchyma well extrathyroid...
Aims SMAD 4 acts as a tumour suppressor, and the loss of is associated with poor prognosis in colorectal cancer ( CRC ) patients. Although next‐generation sequencing NGS enabled us to detect numerous genetic alterations single assay, clinical significance alteration detected has not been fully investigated. The aim this study was evaluate clinicopathological characteristics . Methods results We retrospectively investigated 201 patients stage I– IV , by using 415‐gene panel. To analyse...
This study seeks to determine whether high-resolution in vitro helical CT can show the internal structure of small axillary nodes and establish characteristics benign versus metastatic patients with breast cancer.We obtained images 212 excised from 19 cancer. The longest mean size was 5.9 mm, range 0.5 26.5 mm. hilar cortical characteristics, size, ratio axis shortest were evaluated. findings correlated histologic findings.Pathologic assessment a central low-density hilum visualized on...
Ribosome biogenesis starts with transcription of the large ribosomal RNA precursor (47S pre-rRNA), which soon combines numerous factors to form 90S pre-ribosome in nucleolus. Although subsequent separation pre-90S particle into pre-40S and pre-60S particles is critical for production process mature small subunits, its molecular mechanisms remain undetermined. Here, we present evidence that p32, fibrillarin (FBL), Nop52 play key roles this step. Mass-based analyses combined immunoblotting...
Pancreatic ductal adenocarcinoma (PDAC) is currently one of the most intractable malignancies with a typical scirrhous pattern in histology.Due to its abundant tumor stroma and scant vascularization, chemotherapeutic agents are considered inefficiently permeable cancer nests, making it highly difficult cure patients PDAC.However, PDAC also owe intractability other critical factors such as cellular interaction between cells microenvironment well architectural barriers, which increases...
Assignment of all transcription factors (TFs) from genome sequence data is not a straightforward task due to the wide variation in TFs among different species. A DNA binding domain (DBD) and contiguous non-DBD with characteristic SCOP or Pfam combination are observed most members TF families. We found that experimentally verified prokaryotes detectable by domains assigned DBDs non-DBDs. Based on this finding, we set up rules detect classify them into 52 Application 154 entirely sequenced...
ABSTRACT A new method of determining the dependence cell growth on initial volume in absence division is presented. The assumptions are that a certain period time either increasing or decreasing, but not both, and independent history cells. Applying this to Gonyaulax polyedra 12 h light-12 dark cycle, between 3rd 12th hours light found be more exponential-like than linear. magnitude determined solely by environmental conditions, age. All cells decrease slightly from 23rd hour, then increase...
In addition to structural domains, most eukaryotic proteins possess intrinsically disordered (ID) regions. Although ID regions often play important functional roles, their accurate identification is difficult. As human transcription factors (TFs) constitute a typical group of with long regions, we regarded them as model all and attempted accurately classify TFs into domains an extremely high fraction besides DNA binding and/or other was detected in our previous investigation, 20% the...
The Genomes TO Protein Structures and Functions (GTOP) database (http://spock.genes.nig.ac.jp/~genome/gtop.html) freely provides an extensive collection of information on protein structures functions obtained by application various computational tools to the amino acid sequences entirely sequenced genomes. GTOP contains annotations 3D structures, families, functions, other useful data a interest in user-friendly ways give deep insight into structure. From initial 1999 version, has been...