A5076142771- Heart Rate Variability and Autonomic Control
- Cancer, Hypoxia, and Metabolism
- Coding theory and cryptography
- Cardiovascular Function and Risk Factors
- graph theory and CDMA systems
- Cardiac Imaging and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Cardiac Valve Diseases and Treatments
- Lymphoma Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Gastric Cancer Management and Outcomes
- Protein Kinase Regulation and GTPase Signaling
- Cell Adhesion Molecules Research
- Myasthenia Gravis and Thymoma
- Finite Group Theory Research
- Gastrointestinal Tumor Research and Treatment
- Neuroblastoma Research and Treatments
- Mechanisms of cancer metastasis
- Cancer Research and Treatments
- Metastasis and carcinoma case studies
- Lung Cancer Treatments and Mutations
- Advanced MRI Techniques and Applications
- Coronary Interventions and Diagnostics
National Cerebral and Cardiovascular Center
2025
Hiraka General Hospital
2013-2024
Niigata University of Health and Welfare
2022-2024
Nippon Medical School
2019-2023
Nagoya University
1961-2023
Tohoku University
1976-2022
Niigata University
1979-2021
Niigata University Medical and Dental Hospital
2018-2020
Tokushima University
2000-2019
Hokkaido University of Education
2019
Abstract The fatty acid synthase (FAS) gene is significantly up-regulated in various types of cancers, and blocking the FAS expression results apoptosis tumor cells. Therefore, considered to be an attractive target for anticancer therapy. However, molecular mechanism by which cells poorly understood. We found that was hypoxia, also accompanied reactive oxygen species (ROS) generation human breast cancer cell lines. activated H2O2, whereas N-acetyl-l-cystein, a ROS inhibitor, suppressed...
The precise mechanism of tako-tsubo-like left ventricular (LV) dysfunction remains unclear, although recent studies have shown that activation sympathetic tone might be involved. However, local release catecholamines from cardiac efferent neurons in patients with LV poorly understood. purpose this study was to investigate evidence the hearts dysfunction.Five consecutive were studied. After confirming apical ballooning and a normal coronary angiogram, sampling blood for measurement plasma...
Abstract Fatty acid synthase (FAS) has been found to be overexpressed in a wide range of epithelial tumors, including breast cancer. Pharmacologic inhibitors FAS cause apoptosis cancer cells and result decreased tumor size vivo. However, how the inhibition induces remains largely unknown. To understand apoptotic pathway resulting from direct FAS, we treated with or without small interfering RNA (siRNA) followed by microarray analysis. Our results indicated that proapoptotic genes BNIP3,...
The percentile volumes υA, υB and υD of A, B D cells in the islets Langerhans were histometrically estimated pancreases from 59 autopsy cases including maturity- growth-onset diabetics nondiabetics. Volumetry was performed microscopically by point counting method using a square-lattice eyepiece, then total cell VA, VB VD calculated islet volume Vi pancreas separately. measurement disclosed prominent difference between three groups. Namely, it only 0.156 0.388 cm3 growth- maturity-onset...
Abstract Tumors require a blood supply for growth and hematogenous metastases. Until recently, most research in this area has focused on the role of angiogenesis, recruitment new vessels into tumor from preexisting vessels. Previously, study breast cancer (IBC), which we used established inflammatory (IBC) xenografts (WIBC‐9) originating patient with IBC (Shirakawa et al. , Cancer Res 2001:61:445–451), reported observing vasculogenic mimicry (VM), condition bloodstreams within tissue are not...
Abstract PTEN (phosphatase and tensin homologue deleted on chromosome 10) has been shown to be inactivated in a wide variety of cancers, the role this gene as tumor suppressor well established. On other hand, results recent animal studies clinical evidence indicate that is also involved metastasis suppression. Although known play key controlling cell growth apoptosis, how exerts function remains largely unknown. Recently, microarray analysis identified Drg-1 (differentiation related 1) one...
Abstract RhoC is a member of the Ras-homologous family genes which have been implicated in tumorigenesis and tumor progression. However, exact role controversial yet to be clarified. We examined effect on prostate cells found that had no cell proliferation vitro or growth mice. significantly enhanced metastatic ability these animals, suggesting affects only metastasis but not cells. The results our immunohistochemical analyses specimens from 63 patients with cancer indicate expression...
Seven pancreases from nondiabetic autopsy cases were submitted to morphometrical analysis of the islets Langerhans as a preliminary investigation diabetic pancreas. The pancreatic approximately simulated by spheres different sizes randomly dispersed in three-dimensional space; thereon parameters Weibull function assumed for distribution islet radii estimated stereologically chord length measurements on histologic sections taken portions By means topographical comparison number, volume, mean...
Background: The clinical impact of stent edge dissection, tissue protrusion, and incomplete apposition (ISA) after implantation, detectable only on optical coherence tomography (OCT), is still unknown because the natural course has not been investigated. Methods Results: All consecutive patients with angina pectoris in whom both intravascular ultrasound (IVUS) OCT were performed immediately stenting at follow-up included present study. history OCT-detected ISA during was A total 36 39...
Gastrointestinal stromal tumor (GIST) is currently considered to be derived from the interstitial cells of Cajal (ICC). To test hypothesis that omental mesenchymal also a type GIST, we evaluated expression specific molecules in and c‐kit gene mutation tumors, identified possible counterpart ICC omentum. Immunohistochemically, all tumors ( n = 5) were positive for both KIT CD34, three five an embryonic form smooth‐muscle myosin heavy chain (SMemb). Polymerase reaction–single‐strand...
Abstract Alexander's disease, a leukodystrophy characterized by Rosenthal fibers (RFs) in the brain, is categorized into three subtypes: infantile, juvenile, and adult. Although most are sporadic, occasional familial disease cases have been reported for each subtype. Hereditary adult‐onset shows progressive spastic paresis, bulbar or pseudobulbar palsy, palatal myoclonus symptomatologically, prominent atrophy of medulla oblongata upper spinal cord on magnetic resonance imaging. Recent...
The tumor metastasis suppressor gene Drg-1 has been shown to suppress without affecting tumorigenicity in immunodeficient mouse models of prostate and colon cancer. Expression also found have a significant inverse correlation with or invasiveness various types human However, how exerts its function remains unknown. In the present study, elucidate mechanism action gene, we did microarray analysis that induction significantly inhibited expression activating transcription factor (ATF) 3, member...
The transcription factor HIF-1α (hypoxia inducible 1α) has an essential role in the maintenance of oxygen homeostasis metazoans. expression and activity hypoxic response is regulated at translation post-translational levels. However, mechanism modulator during hypoxia not fully understood. We found that was upregulated by microRNA 130 (miR-130) family. Levels miR-130 family are elevated under hypoxia, their target DDX6 mRNA, which a component P-bodies. Furthermore, we decrease enhanced...