A5006498055- Adipose Tissue and Metabolism
- Mesenchymal stem cell research
- Genomics and Phylogenetic Studies
- Housing, Finance, and Neoliberalism
- Antibiotic Resistance in Bacteria
- RNA and protein synthesis mechanisms
- Bone Metabolism and Diseases
- Olfactory and Sensory Function Studies
- Exercise and Physiological Responses
- Urbanization and City Planning
- Phytochemicals and Antioxidant Activities
- Periodontal Regeneration and Treatments
- Asymmetric Synthesis and Catalysis
- Muscle Physiology and Disorders
- Temporomandibular Joint Disorders
- Oxidative Organic Chemistry Reactions
- Monoclonal and Polyclonal Antibodies Research
- Orthodontics and Dentofacial Orthopedics
- Biochemical effects in animals
- Mast cells and histamine
- Biochemical Analysis and Sensing Techniques
- Housing Market and Economics
- Advanced Chemical Sensor Technologies
- Tissue Engineering and Regenerative Medicine
- Bone Tumor Diagnosis and Treatments
Tokyo Medical University
2018-2025
Shibaura Institute of Technology
2018-2025
UConn Health
2020-2025
Taisho Pharmaceutical (Japan)
2001-2024
Shizuoka University of Art and Culture
2020-2021
Tokyo Medical University Hospital
2015-2020
October 6 University
2018
Marymount University
2016
The University of Tokyo
2003-2015
University of Tokyo Hospital
2015
The Rice Annotation Project Database (RAP-DB) was created to provide the genome sequence assembly of International Genome Sequencing (IRGSP), manually curated annotation sequence, and other genomics information that could be useful for comprehensive understanding rice biology. Since last publication RAP-DB, IRGSP has been revised reassembled. In addition, a large number rice-expressed tags have released, functional resources produced worldwide. Thus, we thoroughly updated our by manual...
Recent studies have demonstrated that the interaction of dietary constituents with taste and olfactory receptors nociceptors expressed in oral cavity, nasal cavity gastrointestinal tract regulate homeostasis through activation neuroendocrine system. Polyphenols, which 8000 been identified to date, represent greatest diversity secondary metabolites plants, most are bitter some them astringent. Epidemiological shown polyphenol intake contributes maintaining improving cardiovascular, cognitive...
The human genome sequence defines our inherent biological potential; the realization of biology encoded therein requires knowledge function each gene. Currently, in this area is still limited. Several lines investigation have been used to elucidate structure and genes genome. Even so, gene prediction remains a difficult task, as varieties transcripts may vary great extent. We thus performed an exhaustive integrative characterization 41,118 full-length cDNAs that capture complete functional...
We present here the annotation of complete genome rice Oryza sativa L. ssp. japonica cultivar Nipponbare. All functional annotations for proteins and non-protein-coding RNA (npRNA) candidates were manually curated. Functions identified or inferred in 19,969 (70%) proteins, 131 possible npRNAs (including 58 antisense transcripts) found. Almost 5000 annotated protein-coding genes found to be disrupted insertional mutant lines, which will accelerate future experimental validation annotations....
Human dental pulp stem cells (DPSCs), which have the ability to differentiate into multiple lineages, were recently identified. DPSCs can be collected readily from extracted teeth and are now considered a type of mesenchymal cell with higher clonogenic proliferative potential than bone marrow (BMSCs). Meanwhile, treatment severe defects, such as fractures, cancers, congenital abnormalities, remains great challenge, novel regenerative techniques highly anticipated. Several studies previously...
Although the introduction of tumor necrosis factor (TNF) inhibitors represented a significant advance in treatment rheumatoid arthritis (RA), traditional anti-TNFα antibodies are somewhat immunogenic, and their use results formation anti-drug (ADAs) loss efficacy (secondary failure). Ozoralizumab is trivalent, bispecific NANOBODY ® compound that differs structurally from IgGs. In this study we investigated suppressant effect ozoralizumab adalimumab, an IgG, on induction ADAs human TNF...
ABSTRACT We sequenced the genome of Theileria orientalis , a tick-borne apicomplexan protozoan parasite cattle. The focus this study was comparative analysis T . relative to other highly pathogenic species, parva and annulata induce transformation infected cells lymphocyte or macrophage/monocyte lineages; in contrast, does not uncontrolled proliferation leukocytes multiplies predominantly within erythrocytes. While synteny across homologous chromosomes three species found be well conserved...
Here we report the new features and improvements in our latest release of H-Invitational Database (H-InvDB; http://www.h-invitational.jp/ ), a comprehensive annotation resource for human genes transcripts. H-InvDB, originally developed as an integrated database transcriptome based on extensive large sets full-length cDNA (FLcDNA) clones, now provides 120 558 mRNAs extracted from International Nucleotide Sequence Databases (INSD), addition to 54 978 FLcDNAs, H-InvDB_4.6. We mapped those...
Sphingosine 1-phosphate (S1P) regulates lymphocyte trafficking through the type 1 sphingosine receptor (S1P(1)) and participates in many pathological conditions, including autoimmune diseases. We developed a novel S1P(1)-selective antagonist, TASP0277308, which is structurally unrelated to S1P. This antagonist competitively inhibited S1P-induced cellular responses, such as chemotaxis internalization. Furthermore, differing from previously reported S1P(1) antagonists, TASP0277308 demonstrated...
Muscle disuse induces atrophy through increased reactive oxygen species (ROS) released from damaged mitochondria. Mitophagy, the autophagic degradation of mitochondria, is associated with ROS production. However, mitophagy activity status during disuse-induced muscle has been a subject debate. Here, we developed new reporter mouse line to examine how affected in skeletal muscles. Mice expressing tandem mCherry-EGFP proteins on mitochondria were then used monitor dynamics activity. The mice...
Abstract In clinical studies, the next-generation anti-tumor necrosis factor-alpha (TNF-α) single domain antibody ozoralizumab showed high efficacy shortly after subcutaneous injection. To elucidate mechanism underlying rapid onset of effects ozoralizumab, we compared biodistribution kinetics and adalimumab injection in an animal model arthritis. Alexa Fluor 680-labeled were administered by once (2 mg/kg) at five weeks induction collagen-induced arthritis (CIA) model. The time-course changes...
Biologics have become an important component of treatment strategies for a variety diseases, but the immunogenicity large immune complexes (ICs) and aggregates biologics may increase risk adverse events is concern it remains unclear whether ICs consisting intrinsic antigen therapeutic antibodies are actually involved in acute local inflammation such as injection site reaction (ISR). Ozoralizumab trivalent, bispecific NANOBODY® compound that differs structurally from IgGs. Treatment with...
Background Several epidemiological studies and intervention trials have demonstrated that grapes blueberries, which are rich in flavanols, can lower the risk of cardiovascular disease. However, mechanisms action these compounds remain unclear due to their low bioavailability.
Abstract Craniometaphyseal dysplasia (CMD), a rare craniotubular disorder, occurs in an autosomal dominant (AD) or recessive (AR) form. CMD is characterized by hyperostosis of craniofacial bones and metaphyseal flaring long bones. Many patients with suffer from neurological symptoms. The pathogenesis not fully understood. Treatment limited to surgery. Here, we report knock (KI) mouse model for AR carrying Cx43 R239Q mutation. KI/KI mice replicate typical features CMD, including thickening...
Flavan-3-ols (FLs), astringent polyphenols, are known to have low bioavailability and induce excessive sympathetic nervous system activation. This study aimed compare the effects of FLs on brown, subcutaneous, visceral adipose tissue in mice. C57BL/6J male mice fed a standard or high-fat diet were given water 50 mg/kg FL orally by gavage for 2 weeks. Excised inguinal, epididymal fat tissues prepared frozen sectioning. After hematoxylin eosin (HE) staining, administration each observed,...
Dystrophic calcification, a type of ectopic refers to the pathological deposition calcium ions in soft tissues. While cases have been reported various regions body, its occurrence head and neck is rare. Here, we present case dystrophic calcification buccal mucosa. The patient, 54-year-old man, initially visited his local dentist with complaints swelling pain right mucosa, but cause remained unidentified. He was subsequently referred our department for further evaluation. At initial visit, he...
Although alveolar bone grafting (ABG) is the standard treatment for cleft lip and palate with clefts, no studies have visually demonstrated qualitative changes in grafted bones over time. In this study, authors attempted to depict ossification of time using color mapping based on differences Hounsfield units (HUs). Alveolar was performed 7 cases. Computed tomography data procured ∼1 month before ABG, 1 day after surgery, 6 months surgery were extracted Mimics (version 26.0)—a medical image...
Abstract Histological analysis is vital for understanding skeletal muscle diseases. However, quantifying data requires much effort, so automation expected to reduce workload. The present study proposes a semi‐automated method quantify expressed paired box protein (Pax‐7) /bromodeoxyuridine (BrdU)‐positive cells. Soleus was harvested from mice 2 weeks after oral administration of the epicatechin tetramer cinnamantanin A2 (A2), known induce hypertrophy. Before necropsy, were treated with BrdU...
Polyphenols are a group of compounds identified as secondary metabolites plants, with 8,000 types to date. Previous research findings have indicated the potential anti-inflammatory properties polyphenols, studies suggesting reduction in disease risk and therapeutic benefits observed various diseases, including diabesity, neurodegeneration, cancer, cardiovascular disease. The objective this study was comprehensively analyze polyphenol composition extracts Greek mountain tea (GMT) wheat germ...