A5103084277- Metabolism and Genetic Disorders
- Microbial Natural Products and Biosynthesis
- Biochemical Acid Research Studies
- Amino Acid Enzymes and Metabolism
- Alcoholism and Thiamine Deficiency
- Prostate Cancer Treatment and Research
- Ovarian cancer diagnosis and treatment
- Bladder and Urothelial Cancer Treatments
- Ion channel regulation and function
- GaN-based semiconductor devices and materials
- Biochemical and Molecular Research
- Lipid Membrane Structure and Behavior
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Coenzyme Q10 studies and effects
- Ga2O3 and related materials
- Plant biochemistry and biosynthesis
- Biochemical effects in animals
- Testicular diseases and treatments
- Microbial Metabolism and Applications
- Mitochondrial Function and Pathology
- Gastric Cancer Management and Outcomes
- Free Radicals and Antioxidants
- Immunotherapy and Immune Responses
- Neurological disorders and treatments
Yokohama City University Medical Center
2014-2025
Yokohama City University
2014-2025
Denka (Japan)
1996-2025
Nagoya University
2024-2025
Niigata Cancer Center Hospital
2015-2024
Tokyo Metropolitan Neurological Hospital
2008-2024
Kumamoto University Hospital
2023
National Institute of Advanced Industrial Science and Technology
2008-2022
Kyoto University
1982-2022
Biomedical Research Institute
2019-2022
The cerebellar inositol 1,4,5-trisphosphate (InsP3) receptor is a high molecular weight glycoprotein abundantly expressed in Purkinje cells.The subunit structure of the InsP3 protein was examined by cross-linking experiments.Agarose-polyacrylamide gel electrophoresis cross-linked materials demonstrated that InsPs composed four noncovalently bound identical subunits each with M, 320,000 both purified and microsome-bound states.Chromatography on calmodulin-Sepharose column Ca2+-dependent...
Abstract Pentraxin 3 (PTX3) and C‐reactive protein (CRP) are members of the pentraxin superfamily. PTX3 expression is induced in response to inflammatory signals, produced at sites inflammation by several types cell, primarily monocytes/macrophages, dendritic cells (DCs), endothelial cells, smooth muscle (SMCs), fibroblasts, but not hepatocytes, which a major source CRP. The aim our study was investigate pattern human atherosclerotic lesions using novel monoclonal antibody against PTX3. We...
We have succeeded in the growth of europium (Eu)-doped GaN layer grown by organometallic vapor-phase epitaxy (OMVPE) and demonstrated first low-voltage operation current-injected red emission from a p-type/Eu-doped/n-type light-emitting diode (LED) at room temperature. The bright was obtained with an applied voltage as low 3 V under normal lighting conditions. At dc current 20 mA, output power, integrated over 5D0–7F2 transition Eu3+ ions (around 621 nm), 1.3 µW. This result suggests novel...
Familiarity Does Not Breed Contempt Female mating preference is influenced by social familiarity in various species from fish to primates. Okuyama et al. (p. 91 ) showed Japanese rice that females prefer mate with visually familiarized males over unfamiliar and this mediated specific neuromodulatory neurons the female brain.
Daytime radiative cooling outdoors is a passive method that emits thermal radiation toward the sky while reflecting sunlight. Many different daytime coolers have been developed, and some commercialized. Coatings offer advantages in ease of application versatility across surfaces. Typical coatings are mixtures powders or particles polymer hosts. As these paintings reflect sunlight diffusively, coating thicknesses submillimeters thicker. Thick result high resistance, which undesirable for...
Thioviridamide is a unique peptide antibiotic containing five thioamide bonds from Streptomyces olivoviridis. Draft genome sequencing revealed gene (the tvaA gene) encoding the thioviridamide precursor peptide. The biosynthesis cluster was identified by heterologous production of in lividans.
Intratumoral synthesis of dihydrotestosterone (DHT) from precursors cannot completely explain the castration resistance prostate cancer. We showed that DHT was intratumorally synthesized inactive androgen metabolites 5α-androstane-3α/β,17β-diol (3α/β-diol) in cancer cells via different pathways a concentration-dependent manner. Additionally, long-term culture androgen-deprived media increased transcriptomic expression 17β-hydroxysteroid dehydrogenase type 6 (HSD17B6), key enzyme oxidative...
Non-neuronal acetylcholine (ACh) is predicted to function as a local cell signaling molecule. However, the physiological significance of synthesis non-neuronal ACh in intestine remains unclear. Here, experiments using crypt-villus organoids that lack nerve and immune cells culture led us suggest endogenous synthesized intestinal epithelium evoke growth differentiation through activation muscarinic receptors (mAChRs). The extracts cultured showed noticeable capacity for was sensitive potent...
Aims: The association between the expression of androgen receptor (AR) or androgen-converting enzymes and malignant potential in prostate cancer (PCa) was examined. Methods: PCa specimens from 44 cases stage II, 10 III, four IV two recurrent were semi-quantitatively studied with immunohistochemistry for AR enzymes. Results: scores AR, 5α-reductase type 1 (SRD5A1), 2 (SRD5A2), aldo-keto reductase family member C3 (AKR1C3) metastatic lesion (n = 6) 284.2 (30.1), 300 (0.0), 279.2 (51) 254.2...
We investigated the luminescence properties of Eu-doped GaN (GaN:Eu) grown by atmospheric-pressure organometallic vapor phase epitaxy. The GaN:Eu exhibited radiant red emission due to intra-4f shell transition Eu3+ ions at room temperature. intensity dominant peak was about 4 times higher than that in sample 10 kPa, even though Eu concentration only half kPa sample. This mainly caused enhancement energy transfer from host ions. enhanced resulted improved a light-emitting diode.
Heat shock promoters are powerful tools for the precise control of exogenous gene induction in living organisms. In addition to temporal expression, analysis function can also require spatial restriction. Recently, we reported a new method vivo , single‐cell using an infrared laser‐evoked operator (IR‐LEGO) system nematodes ( Caenorhabditis elegans ). It was demonstrated that (IR) irradiation could induce expression single cells without incurring cellular damage. Here, report application...
Furaquinocin (FQ) A, produced by Streptomyces sp. strain KO-3988, is a natural polyketide-isoprenoid hybrid compound that exhibits potent antitumor activity. As first step toward understanding the biosynthetic machinery of this unique and pharmaceutically useful compound, we have cloned an FQ A gene cluster taking advantage fact isoprenoid generally exists in flanking regions mevalonate (MV) pathway actinomycetes. Interestingly, KO-3988 was example microorganism equipped with two distinct...
galactosamine-protein acetylgalactosaminyltransferase (EC 2.4.1.41).Partial purification from salivary gland extracts and acceptor specificity of this purified transferase have been reported (9).Although the preparation was far homogeneous, it found that enzyme acted preferentially on high molecular weight acceptors such as apomucins (deglycosylated submaxillary mucins) or a protein bovine myelin (A1 protein).We undertook to purify characterize an ascites hepatoma, AH 66, in order obtain...