A5084067613- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Multiple and Secondary Primary Cancers
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Surgical Treatments
- Cancer Research and Treatments
- Urologic and reproductive health conditions
- Cancer Cells and Metastasis
- Urinary and Genital Oncology Studies
- Lung Cancer Treatments and Mutations
- Mathematical Biology Tumor Growth
- Hedgehog Signaling Pathway Studies
- Prostate Cancer Treatment and Research
- Cardiac tumors and thrombi
- Cancer-related gene regulation
- Neuroendocrine Tumor Research Advances
- RNA modifications and cancer
- Chromatin Remodeling and Cancer
- Single-cell and spatial transcriptomics
Université de Strasbourg
2015-2025
Hôpital d'Hautepierre
2006-2025
Hôpitaux Universitaires de Strasbourg
2006-2024
Inserm
1999-2024
Regenerative NanoMedicine
2022-2024
Hôpital Civil, Strasbourg
1998-2022
Centre Hospitalier de Mulhouse
2009-2015
Institut de Recherche en Hématologie et Transplantation
2014
Hôpital Émile-Roux
2012
Klinik und Poliklinik für Neurologie
2007
Fluorescence videography is a promising technique for assessing bowel perfusion. Fluorescence-based enhanced reality (FLER) novel concept, in which dynamic perfusion cartogram, generated by computer analysis, superimposed on to real-time laparoscopic images. The aim of this experimental study was assess the accuracy FLER detecting differences small resection-anastomosis model.A ischaemic segment created laparoscopically 13 pigs. Animals were allocated having anastomoses performed at either...
Abstract Immune checkpoint inhibitors (ICI) represent the cornerstone for treatment of patients with metastatic clear cell renal carcinoma (ccRCC). Despite a favorable response subset patients, others experience primary progressive disease, highlighting need to precisely understand plasticity cancer cells and their cross-talk microenvironment better predict therapeutic personalize treatment. Single-cell RNA sequencing ccRCC at different disease stages normal adjacent tissue (NAT) from...
Abstract Metastatic renal cell carcinoma is resistant to current therapies. The phosphoinositide 3-kinase (PI3K)/Akt signaling cascade induces growth, transformation, and neovascularization. We evaluated whether targeting this pathway could be of therapeutic value against human carcinoma. activation the PI3K/Akt its role in progression was vitro seven lines by Western blot, counting, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, terminal deoxyribonucleotide...
The Fuhrman system is the most widely used nuclear grading for renal cell carcinoma (RCC). Although grade accepted as a significant prognostic factor, its reproducibility, reported in limited number of series available literature, appears to be low.Between 1980 and 1990, 255 cases RCC (pT1-3bN0M0) were treated with radical nephrectomy at Department Urology, University Hospital, Strasbourg, France. In retrospective multicenter study, 3 pathologists independently classified 241 these according...
Human clear cell renal carcinoma (CRCC) remains resistant to therapies. Recent advances in Hypoxia Inducible Factors (HIF) molecular network led targeted therapies, but unfortunately with only limited clinical significance. Elucidating the processes involved kidney tumorigenesis and resistance is central development of improved not for cancer many, if all, types. The oncogenic PI3K/Akt, NF-kB MAPK pathways are critical tumorigenesis. sonic hedgehog (SHH) signaling pathway crucial normal...
Extracellular vesicles (EVs) are increasingly envisioned as the next generation of biological pro-regenerative nanotherapeutic agents, has already been demonstrated for heart, kidney, liver, and brain tissues; lung injury repair; skin regeneration. Herein, we explore another potential EV therapeutic application, fistula healing, together with a local minimally invasive delivery strategy. Allogenic extracellular from adipose tissue-derived stromal cells (ASCs) administered in porcine model...
Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UT) are aggressive neoplasms. Data linking BAF alterations with tumor microenvironment (TME) and efficacy of immune checkpoint inhibitors (ICI) contradictory. The TME SMARCA4-UT their response to ICI unknown.Patients diagnosed in our institution were included. Immunostainings for tertiary lymphoid structures (TLS), cell markers, checkpoints assessed. Validation was performed using an independent transcriptome dataset including...
Prostate cancer (PCa) is a leading cause of cancer-related deaths. The slow evolution precancerous lesions to malignant tumors provides broad time frame for preventing PCa. To characterize prostatic intraepithelial neoplasia (PIN) progression, we conducted longitudinal studies on Pten(i)pe-/- mice that recapitulate prostate carcinogenesis in humans. We found early PINs are hypoxic and hypoxia-inducible factor 1 alpha (HIF1A) signaling activated luminal cells, thus enhancing progression....
Abstract Renal medullary carcinoma (RMC) is an aggressive tumour driven by bi-allelic loss of SMARCB1 and tightly associated with sickle cell trait. However, the cell-of-origin oncogenic mechanism remain poorly understood. Using single-cell sequencing human RMC, we defined transformation thick ascending limb (TAL) cells into epithelial-mesenchymal gradient RMC renal epithelial transcription factors TFCP2L1 , HOXB9 MITF gain MYC NFE2L2 -associated ferroptosis resistance programs. We describe...
<b>Background and study aims:</b> MAGNAMOSIS forms a compression anastomosis using self-assembling magnetic rings that can be delivered via flexible endoscopy. The system has proven to effective in full-thickness porcine small-bowel anastomoses. aim of this was show the feasibility hybrid endoscopic colorectal surgery compare conventional stapled <b>Methods:</b> A total 16 swine weighing 35 – 50 kg were used following animal ethical committee approval. first an acute model establish...
Significance of the Pseudocapsule on MRI Renal Neoplasms and Its Potential Application for Local Staging: A Retrospective StudyCatherine Roy, Sr.1, Sofiane El Ghali1, Xavier Buy1, Veronique Lindner1, Herve Lang1, Christian Saussine2 Didier Jacqmin2Audio Available | Share
Abstract Clear cell renal carcinoma (CCRC) is responsible for 2% of cancer-related deaths worldwide and resistant to virtually all therapies, indicating the importance a search new therapeutic targets. Parathyroid hormone-related protein (PTHrP) polyprotein derived from normal malignant cells that regulates growth. In current study, we show blocking PTHrP with antibodies or antagonizing common parathyroid hormone (PTH)/PTHrP receptor, PTH1 dramatically blunts expansion human CCRC in vitro by...
Abstract Metastatic renal cell carcinoma (RCC) remains refractory to therapies. The nuclear factor-κB (NF-κB) transcription factor is involved in growth, motility, and vascularization. We evaluated whether targeting NF-κB could be of therapeutic prognostic values human RCC. activation the pathway RCC cells tumors was investigated by Western blot. In vitro, effects BAY 11-7085 sulfasalazine, two inhibitors, on tumor growth were counting, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium...
Human conventional renal cell carcinoma (CRCC) remains resistant to therapy. The RNA-binding protein HuR regulates the stability and/or translation of multiple messenger RNAs involved in malignant transformation. In this study, we aimed evaluate potential role pathology. Using seven human CRCC lines expressing or not von Hippel-Lindau (VHL) tumor suppressor gene as well 15 normal/renal pairs, showed that is overexpressed all tumors independently VHL status. Futhermore, cytoplasmic presence...
Abstract Collecting duct carcinoma (CDC) is a kidney cancer subtype that thought to arise from principal cells in distal parts of the collecting ducts. Some studies suggested an overlap CDC with upper tract urothelial (UTUC), making pathological diagnosis challenging. Herein, we performed for first time transcriptome sequencing and compared them UTUC renal cell subtypes. We discovered displays unique transcriptomic signature among subtypes, putative origin convoluted tubules. Hierarchical...
Human clear cell renal carcinoma (CCC) remains resistant to treatments despite the progress in targeted therapies. Several signaling pathways acting during development are reactivated kidney tumorigenesis; this is case of sonic hedgehog (SHH)-Gli. Interestingly, precursor active vitamin D3 (VD3), cholecalciferol, has been demonstrated be a strong inhibitor SHH-Gli signaling. Here, we show preclinical efficacy cholecalciferol CCC both vitro and vivo . A panel lines, tumors normal...
Human conventional renal cell carcinoma (CCC) remains resistant to current therapies. Focal Adhesion Kinase (FAK) is upregulated in many epithelial tumors and clearly implicated nearly all facets of cancer. However, only few reports have assessed whether FAK may be associated with tumorigenesis. In this study, we investigated the potential role growth human CCC using a panel lines expressing or not von Hippel-Lindau (VHL) tumor suppressor gene as well normal/tumoral tissue pairs. was found...
The efficacy of immune checkpoint inhibitors varies in clear-cell renal cell carcinoma (ccRCC), with notable primary resistance among patients. Here, we integrate epigenetic (DNA methylation) and transcriptome data to identify a ccRCC subtype characterized by cancer-specific promoter hypermethylation silencing Polycomb targets. We develop validate an index methylation-based (iMES) that predicts inhibition (ICI) the BIONIKK trial. High iMES is associated VEGF pathway silencing, endothelial...