A5112629342- Cardiac Ischemia and Reperfusion
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Peripheral Artery Disease Management
- Inflammatory Myopathies and Dermatomyositis
- Muscle Physiology and Disorders
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Nutrition and Health in Aging
- Cardiovascular and exercise physiology
- Diabetic Foot Ulcer Assessment and Management
- Cardiac Arrest and Resuscitation
- Nitric Oxide and Endothelin Effects
- Diet, Metabolism, and Disease
- Cannabis and Cannabinoid Research
- Anesthesia and Neurotoxicity Research
- Exercise and Physiological Responses
- Pain Management and Treatment
- Asthma and respiratory diseases
- Organ Transplantation Techniques and Outcomes
- Muscle and Compartmental Disorders
- Allergic Rhinitis and Sensitization
- Optical Imaging and Spectroscopy Techniques
- Sports Performance and Training
Mitochondrie, stress oxydant et protection musculaire
2016-2025
Université de Strasbourg
2016-2025
Hôpitaux Universitaires de Strasbourg
2012-2024
Hôpital Civil, Strasbourg
2011-2021
Institut de Virologie
2014-2015
Institut de génétique et de biologie moléculaire et cellulaire
2012-2013
Inserm
2012-2013
Centre National de la Recherche Scientifique
2012
Statins protect against cardiovascular-related mortality but induce skeletal muscle toxicity. To investigate mechanisms of statins, we tested the hypothesis that statins optimized cardiac mitochondrial function impaired vulnerable by inducing different level reactive oxygen species (ROS). In atrium patients treated with ROS production was decreased and oxidative capacities were enhanced together an extensive augmentation mRNAs expression peroxisome proliferator-activated receptor gamma...
Our aim was to evaluate a fluorescence-based enhanced-reality system assess intestinal viability in laparoscopic mesenteric ischemia model.A small bowel loop exposed, and 3 4 vessels were clipped 6 pigs. Indocyanine green (ICG) administered intravenously 15 minutes later. The illuminated with an incoherent light source laparoscope (D-light-P, KarlStorz). ICG fluorescence signal analyzed Ad Hoc imaging software (VR-RENDER), which provides digital perfusion cartography that superimposed the...
Cannabis has potential therapeutic use but tetrahydrocannabinol (THC), its main psychoactive component, appears as a risk factor for ischemic stroke in young adults. We therefore evaluate the effects of THC on brain mitochondrial function and oxidative stress, key factors involved stroke. Maximal capacities V max (complexes I, III, IV activities), succ II, tmpd (complex activity), together with coupling (V max/V 0), were determined control conditions after exposure to isolated mitochondria...
Introduction: Many COVID-19 patients present with severe long-lasting symptoms. They might benefit from a coordination team to manage such complex situations, but late efficacy still needs be determined. Population and Methods: Out of 105 contacts, 45 had two phone consultations separated by personalized support 15 22 months, respectively, after COVID infection. Self-reported symptoms, feelings improvement ability return work allowed us determine the therapeutic strategy proposed. Results:...
Aims: Although statins are the most widely used cholesterol-lowering agents, they associated with a variety of muscle complaints. The goal this study was to characterize effects on mitochondrial apoptosis pathway induced by oxidative stress in skeletal using human biopsies as well vivo and vitro models. Results: Statins increased H2O2 production, Bax/Bcl-2 ratio, TUNEL staining deltoid patients statin-associated myopathy. Furthermore, atorvastatin treatment for 2 weeks at 10 mg/kg/day rats...
Physical exercise exacerbates the cytotoxic effects of statins in skeletal muscle. Mitochondrial impairments may play an important role development muscular symptoms following statin treatment. Our objective was to characterize mitochondrial function and reactive oxygen species (ROS) production muscle after exhaustive atorvastatin-treated rats. The animals were divided into four groups: resting control (CONT; n = 8) rats (CONT+EXE; as well (ATO; 10) (ATO+EXE; that treated with atorvastatin...
Abstract Background Breast cancer patients are commonly treated with sequential administrations of epirubicin–cyclophosphamide (EC) and paclitaxel (TAX). The chronic effect this treatment induces skeletal muscle alterations, but the specific each chemotherapy agent is unknown. This study aimed to investigate EC or TAX administration on homeostasis in breast patients. Methods Twenty early undergoing followed by chemotherapies were included. Two groups 10 women established performed vastus...
Osmoregulating decapods such as the Mediterranean green crab Carcinus aestuarii, possess two groups of spatially segregated gills: anterior gills serve mainly respiratory purposes, while posterior contain osmoregulatory structures. The coexistence similar tissues serving partially different functions allows studying differential adaptation, in terms free radical metabolism, upon salinity change. Crabs were immersed for weeks seawater (SW) (37ppt), diluted SW (dSW, 10ppt) and concentrated...
Muscle injury resulting from ischemia-reperfusion largely aggravates patient prognosis but whether and how muscle phenotype modulates ischemia-reperfusion-induced mitochondrial dysfunction remains to be investigated. We challenged the hypothesis that glycolytic muscles are more prone than oxidative skeletal muscles. therefore determined simultaneously effect of 3 hours ischemia induced by aortic clamping followed 2 reperfusion (IR, n=11) on both gastrocnemius soleus muscles, as compared...
Both leukotrienes and neutrophils have been linked to plaque destabilization. Despite being evoked, the role of leukotriene B4 (LTB4) in neutrophil recruitment plaques concomitant effects these two actors on stability remain be proven. Since both are elicited during endotoxaemia, a condition associated with risk cardiovascular events, we investigated whether endotoxaemia promotes LTB4-mediated infiltration explored roles LTB4 Endotoxaemia induced by repeated peritoneal endotoxin injections...
Delta 9 tetrahydrocannabinol (THC), the main component of cannabis, has adverse effects on cardiovascular system, but whether concomitant ethanol (EtOH) and aging modulate its toxicity is unknown. We investigated dose responses THC vehicle, EtOH, mitochondrial respiration reactive oxygen production in both young old rat cardiac mitochondria (12 90 weeks). dose-dependently impaired groups, such impairment was enhanced aged rats (−97.5 ± 1.4% vs. −75.6 4.0% at 2 × 10−5 M, IC50: 0.7 0.05 1.3...
Objective Obesity and metabolic complications, such as type 2 diabetes nonalcoholic fatty liver disease (NAFLD), are one of the greatest public health challenges 21st century. The major role high sugar carbohydrate consumption rather than caloric intake in obesity NAFLD pathophysiology remains a subject debate. A low-carbohydrate but high-fat diet (LCHFD) has shown promising results management, its effects preventing need to be detailed. This study aims compare LCHFD with high-sugar...
Ageing is associated with skeletal muscle impairment. Changes in mitochondrial homeostasis are thought to play a key role this process. This study examined whether chronic intake of polyphenols (PPs), which known be modulators oxidative stress, might prevent the age-related decline functions muscle. Three groups 10 Wistar rats were investigated. Rats aged 16 weeks compared 40 that given 75 mg kg(-1) day(-1) PPs or solvent drinking water starting at week 16. Mitochondrial respiratory chain...
AimsHaemostasis interrupts bleeding from disrupted blood vessels by activating platelet aggregation and coagulation. A similar mechanism termed thrombosis generates obstructive thrombi inside diseased arteries. As a consequence of this similarity, current anti-thrombotic agents increase the risk bleeding. Atherosclerotic plaques produce significant amounts prostaglandin E2 (PGE2), which activates its receptor EP3 on platelets aggravates atherothrombosis. We investigated whether blocking...