A5011668631- Asthma and respiratory diseases
- Inflammatory mediators and NSAID effects
- Nitric Oxide and Endothelin Effects
- Pulmonary Hypertension Research and Treatments
- Eicosanoids and Hypertension Pharmacology
- Respiratory and Cough-Related Research
- Estrogen and related hormone effects
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Cholinesterase and Neurodegenerative Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmacological Receptor Mechanisms and Effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mast cells and histamine
- Inhalation and Respiratory Drug Delivery
- Cardiovascular Health and Disease Prevention
- Phosphodiesterase function and regulation
- Immune Response and Inflammation
- Cardiovascular Function and Risk Factors
- Cardiac and Coronary Surgery Techniques
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Venous Thromboembolism Diagnosis and Management
- Sexual function and dysfunction studies
Université Paris Cité
2012-2023
Sorbonne Paris Cité
2013-2023
Inserm
2014-2023
Université Sorbonne Paris Nord
2011-2023
Sorbonne Université
2020-2023
Laboratoire de Recherche Vasculaire Translationnelle
2015-2023
Université Paris 1 Panthéon-Sorbonne
2021
Hôpital Bichat-Claude-Bernard
2020
Centre for Inflammation Research
2020
Queen's Medical Centre
2020
Leukotrienes (LT) are potent spasmogenic agents in human isolated bronchial and pulmonary venous muscle preparations. Treatment of veins with the L-serine borate complex (45 mM; 30 min) did not alter LTC4 pD2 values these The cysteinyl LT antagonists, ICI 198615, MK 571 SKF 104353, significantly shifted to right concentration-effect curves airways pKB against 8.4 for 8.6 8.0 104353. Similar results were found LTD4. In contrast, antagonists inhibit LTD4 contractions veins. LTE4 was a partial...
Rationale: Chronic obstructive pulmonary disease (COPD) is associated with lung fibroblast senescence, a process characterized by the irreversible loss of replicative capacity secretion inflammatory mediators. However, mechanisms this phenomenon remain poorly defined.Objectives: The aim study was to analyze role prostaglandin E2 (PGE2), known be increased in COPD fibroblasts, inducing senescence and related inflammation vitro fibroblasts vivo mice.Methods: Fibroblasts were isolated from...
Silver nanoparticles (AgNPs) are microbicidal agents which could be potentially used as an alternative to antivirals treat human infectious diseases, especially influenza virus infections where have generally proven unsuccessful. However, concerns about the use of AgNPs on humans arise from their potential toxicity, although mechanisms not well-understood. We show here, in context infection lung epithelial cells, that down-regulated induced CCL-5 and -IFN-β release (two cytokines important...
Abstract The association between matrix metalloproteinases (MMPs), tissue inhibitor of (TIMPs) and obesity as well obesity-related disease including metabolic syndrome is not fully explored. Our aims are that: (i) to evaluate the plasma levels MMP-1, MMP-2, MMP-3, MMP-9, TIMP-1, TIMP-2 their ratios in non-obese people, overweight obese people with or without syndrome, (ii) investigate correlations MMPs TIMPs several anthropometric parameters, blood pressure, endothelial function....
To characterize the prostanoid receptors on human pulmonary smooth muscle involved in vasodilatations, isolated arteries and veins were contracted with norepinephrine (10 μ M ) vessels subsequently challenged different prostanoid‐receptor agonists absence or presence of selective antagonists. Prostaglandin D 2 (PGD DP‐receptor agonist, BW245C, induced relaxations venous preparations. The pD values were: 6.88±0.11 ( n =17) 7.31±0.12 =5), respectively. relaxant responses by PGD reduced...
Both leukotrienes and neutrophils have been linked to plaque destabilization. Despite being evoked, the role of leukotriene B4 (LTB4) in neutrophil recruitment plaques concomitant effects these two actors on stability remain be proven. Since both are elicited during endotoxaemia, a condition associated with risk cardiovascular events, we investigated whether endotoxaemia promotes LTB4-mediated infiltration explored roles LTB4 Endotoxaemia induced by repeated peritoneal endotoxin injections...
Iloprost and cicaprost (IP‐receptor agonists) induced relaxations in the histamine‐ (50 μ M ) contracted human bronchial preparations (pD 2 values, 6.63±0.12 6.86±0.08; E max 90±04 65±08% of papaverine response for iloprost ( n =6) =3), respectively). Prostaglandin (PGE misoprostol (EP‐receptor agonist) relaxed histamine‐contracted 7.13±0.07 6.33±0.28; 67±04 57±08% PGE =14) =4), In addition, both were inhibited by AH6809 (DP/EP 1 /EP ‐receptor antagonist; 3 ; =5–6). The ‐induced not modified...
1. Acetylcholine (ACh) and the M1 agonists (McN-A-343 or PD142505) relaxed human isolated pulmonary arteries which were pre-contracted with noradrenaline (10 microM). In preparations where endothelium had been removed ACh induced a contractile response whereas no effect. 2. ACh- McN-A-343-induced relaxations abolished after treatment of endothelium-intact drug combination NG-nitro-L-arginine (L-NOARG: 0.1 mM) indomethacin (1.7 3. The affinity (pKB value) for pirenzepine was higher in when...
PGE2 has been shown to induce relaxations in precontracted human pulmonary venous preparations, while arteries this response was not observed. We investigated and characterized the prostanoid receptors which are activated by veins.Human veins were cut as rings set up organ baths presence of a TP antagonist. A pharmacological study performed using selective EP1-4 ligands. The cellular localization EP4 immunohistochemistry their corresponding transcripts also these vessels.PGE2 agonists...
The side effects of cyclooxygenase-2 (COX-2) inhibitors on the cardiovascular system could be associated with reduced prostaglandin (PG)I2 synthesis. Microsomal PGE synthase-1 (mPGES-1) catalyses formation PGE2 from COX-derived PGH2 . This enzyme is induced under inflammatory conditions and constitutes an attractive target for novel anti-inflammatory drugs. However, it not known whether mPGES-1 devoid effects. aim this study was to compare, in vitro, COX-2 vascular tone human blood...
To characterize the prostanoid receptors (TP, FP, EP 1 and/or 3 ) involved in vasoconstriction of human pulmonary veins, isolated venous preparations were challenged with different prostanoid‐receptor agonists absence or presence selective antagonists. The stable thromboxane A 2 mimetic, U46619, was a potent constrictor agonist on veins (pEC 50 =8.60±0.11 and E max =4.61±0.46 g; n =15). affinity values for two TP‐antagonists (BAY u3405 GR32191B) versus U46619 BAY u3405: pA =8.94±0.23 ( =3)...