A5068795261- Lung Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular and exercise physiology
- Pulmonary Hypertension Research and Treatments
- Transplantation: Methods and Outcomes
- Heart Failure Treatment and Management
- Heart Rate Variability and Autonomic Control
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Respiratory Support and Mechanisms
- Cardiovascular Function and Risk Factors
- Asthma and respiratory diseases
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Liver Disease and Transplantation
- Mitochondrial Function and Pathology
- Non-Invasive Vital Sign Monitoring
- Neuroscience of respiration and sleep
- Mechanical Circulatory Support Devices
- Cardiovascular Effects of Exercise
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Adipose Tissue and Metabolism
- Effects of Radiation Exposure
- Neuroendocrine Tumor Research Advances
- Blood Pressure and Hypertension Studies
Université de Strasbourg
2015-2025
Mitochondrie, stress oxydant et protection musculaire
2012-2025
Hôpitaux Universitaires de Strasbourg
2013-2024
Hôpital Civil, Strasbourg
1997-2023
New College of Florida
2016
Institut de Génomique Fonctionnelle
2002-2013
Intergroupe Francophone de Cancérologie Thoracique
2012
Institut de Virologie
2003-2008
Czech Academy of Sciences, Institute of Physiology
2005
Centre National de la Recherche Scientifique
2000
A collaboration of multidisciplinary experts on the functional evaluation lung cancer patients has been facilitated by European Respiratory Society (ERS) and Thoracic Surgery (ESTS), in order to draw up recommendations provide clinicians with clear, up-to-date guidelines fitness for surgery chemo-radiotherapy. The subject was divided into different topics, which were then assigned at least two experts. authors searched literature according their own strategies, no central review being...
We have recently demonstrated that the overnight profiles of cardiac interbeat autocorrelation coefficient R-R intervals (rRR) calculated at 1-min are related to changes in sleep electroencephalographic (EEG) mean frequency, which reflect depth sleep. Other quantitative measures Poincaré plots, i.e., standard deviation normal (SDNN) and root square difference among successive (RMSSD), commonly used evaluate heart rate variability. The present study was designed compare nocturnal rRR, SDNN,...
The post-COVID-19 condition, defined as COVID-19-related signs and symptoms lasting at least 2 months persisting more than 3 after infection, appears now a public health issue in terms of frequency quality life alterations. Nevertheless, few data are available concerning long term evolution malnutrition sarcopenia, which deserve further attention.
Delta 9 tetrahydrocannabinol (THC), the main component of cannabis, has adverse effects on cardiovascular system, but whether concomitant ethanol (EtOH) and aging modulate its toxicity is unknown. We investigated dose responses THC vehicle, EtOH, mitochondrial respiration reactive oxygen production in both young old rat cardiac mitochondria (12 90 weeks). dose-dependently impaired groups, such impairment was enhanced aged rats (−97.5 ± 1.4% vs. −75.6 4.0% at 2 × 10−5 M, IC50: 0.7 0.05 1.3...
The reason why young people taking concomitantly cannabis (THC) and ethanol (EtOH) are more prone to stroke is underresearched. To investigate whether an underlying mechanism of increased brain damage could be impaired mitochondrial function, this experiment determined the acute effects EtOH, both alone associated with THC, on respiration oxidative stress (hydrogen peroxide H2O2) (11 weeks) middle-aged (45 in rats, using a high-resolution oxygraph (Oxygraph-2K, Oroboros instruments). In...
The aim of this study was to assess the relative influence on 24-h aldosterone profile adrenocorticotropic system, primarily modulated by a circadian rhythmicity, and renin-angiotensin which is influenced sleep. Cortisol, plasma renin activity (PRA), were measured for 24 h in healthy subjects under basal conditions, once with nocturnal sleep night deprivation followed 8 daytime period displayed high mean levels, pulse amplitude, frequency that reduced during waking periods. During sleep,...
The coronavirus disease 2019 (COVID-19) pandemic has spread rapidly worldwide, with more than two million deaths. Evidence indicates the critical role of vascular endothelium in its pathophysiology but, like potential changes functional vasodilation, effect SARS-CoV-2 at a given distance from acute infection is largely unknown. We assessed brachial artery flow-mediated dilatation (FMD) 27 COVID-19 patients needing conventional or intensive care unit hospitalization, three months after...
Aging is commonly associated with decreased sleep quality and increased periodic breathing (PB) that can influence heart rate variability (HRV). Cardiac autonomic control, as inferred from HRV analysis, was determined, taking into account the patterns. Two groups of 12 young (21.1 +/- 0.8 years) older (64.9 1.9 volunteers underwent electroencephalographic, cardiac, respiratory recordings during one experimental night. Time frequency domain indices were calculated in 5-min segments, together...
Purpose: In the middle-aged, it has been shown that moderate physical activity is associated with increased global HR variability (HRV) and vagal-related HRV indexes. However, relative effect of quantity intensity on still unknown. The purpose this study was to compare indexes in three groups subjects presenting different long-term profiles: sedentary (SED) low-energy expenditure (PAEE) two equivalent PAEE, but differing terms (active (ACT) sportive (SP) individuals). Methods: Forty-three...
The aim of this study was to determine the effect sleep deprivation on 24‐h profile aldosterone and its consequences renal function. Aldosterone main hormonal regulatory factors, ACTH (evaluated by cortisol measurement) renin‐angiotensin system [RAS, evaluated plasma renin activity (PRA) measurement] were determined every 10 min for 24 h in eight healthy subjects supine position, once with nocturnal during total deprivation. Plasma Na + K measured four these subjects. In an additional group...