A5036420936- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Birth, Development, and Health
- Mitochondrial Function and Pathology
- Antioxidant Activity and Oxidative Stress
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Adipokines, Inflammation, and Metabolic Diseases
- Stress Responses and Cortisol
- Muscle metabolism and nutrition
- Immune Cell Function and Interaction
- Adrenal Hormones and Disorders
- Muscle Physiology and Disorders
- Nutrition, Genetics, and Disease
- Sports Performance and Training
- Bioactive Compounds and Antitumor Agents
- Diet, Metabolism, and Disease
- Vitamin D Research Studies
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- Gestational Diabetes Research and Management
- Cancer therapeutics and mechanisms
- Diet and metabolism studies
- Exercise and Physiological Responses
Manchester Academic Health Science Centre
2018-2021
University of Manchester
2015-2021
Wellcome/MRC Institute of Metabolic Science
2018
Wellcome Trust
2018
Inserm
2012-2015
Université de Strasbourg
2012-2015
Institut de génétique et de biologie moléculaire et cellulaire
2013-2015
Centre National de la Recherche Scientifique
2012-2015
Jawaharlal Nehru Centre for Advanced Scientific Research
2008-2009
Institute of Bioinformatics and Applied Biotechnology
2008
Dysfunction of histone acetyltransferases (HATs) leads to several diseases including cancer, diabetes, and asthma. Therefore, small molecule inhibitors activators HATs are being considered as new generation therapeutics. Here, we report the molecular mechanisms p300 HAT inhibition by specific nonspecific inhibitors: garcinol, isogarcinol, 1 (LTK14). The inhibitor behaves a noncompetitive for both acetyl-CoA histone, unlike garcinol isogarcinol. isothermal calorimetric data suggest that there...
Lysine acetyltransferases (KATs), p300 (KAT3B), and its close homologue CREB-binding protein (KAT3A) are probably the most widely studied KATs with well documented roles in various cellular processes. Hence, dysfunction of may result dysregulation gene expression leading to manifestation many disorders. The acetyltransferase activity p300/CREB-binding is therefore considered as a target for new generation therapeutics. We describe here natural compound, plumbagin (RTK1), isolated from...
The transcriptional coregulators PGC-1α and PGC-1β modulate the expression of numerous partially overlapping genes involved in mitochondrial biogenesis energetic metabolism. physiological role is poorly understood skeletal muscle, a tissue high content to produce ATP levels required for sustained contractions. Here we determine muscle using mice, which selectively ablated myofibres at adulthood (PGC-1β((i)skm-/-) mice). We show that myofibre myosin heavy chain composition number, strength...
The bioactive form of vitamin D [1,25(OH)2D3] regulates mineral and bone homeostasis exerts potent anti-inflammatory antiproliferative properties through binding to the receptor (VDR). 3D structures VDR ligand-binding domain with 1,25(OH)2D3 or gemini analogs unveiled molecular mechanism underlying ligand recognition. On basis structure-function correlations, we generated a point-mutated (VDRgem) that is unresponsive 1,25(OH)2D3, but activity which efficiently induced by ligands. Moreover,...
Ageing is associated with skeletal muscle impairment. Changes in mitochondrial homeostasis are thought to play a key role this process. This study examined whether chronic intake of polyphenols (PPs), which known be modulators oxidative stress, might prevent the age-related decline functions muscle. Three groups 10 Wistar rats were investigated. Rats aged 16 weeks compared 40 that given 75 mg kg(-1) day(-1) PPs or solvent drinking water starting at week 16. Mitochondrial respiratory chain...
The effects of mitochondrial uncoupling on skeletal muscle adaptation and maximal exercise capacity are unknown. In this study, rats were divided into a control group (CTL, n = 8) treated with 2,4-dinitrophenol, uncoupler, for 28 days (DNP, 30 mg·kg(-1)·day(-1) in drinking water, 8). DNP had significantly lower body mass (P < 0.05) higher resting oxygen uptake (Vo2, P 0.005). incremental treadmill test showed that running speed economy 0.01) impaired but Vo2 (Vo2max) was the DNP-treated...
Robust inflammatory responses are critical to survival following respiratory infection, with current attention focused on the clinical consequences of Coronavirus pandemic. Epigenetic factors increasingly recognized as important determinants immune responses, and EZH2 is a prominent target due availability highly specific efficacious antagonists. However, very little known about role in myeloid lineage. Here, we show acts macrophages limit activation, neutrophils for chemotaxis. Selective...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Mucosal immunity is critical to survival, with huge attention at present due the Coronovirus pandemic. Epigenetic factors are increasingly recognized as important determinants of immune responses, and EZH2 closest application availability highly-specific efficacious antagonists. However, very little known about role in myeloid lineage, some conflicting reports. Here we show acts macrophages limit inflammatory responses activation, selective genetic deletion results a remarkable gain...