A5015059017- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Meningioma and schwannoma management
- MRI in cancer diagnosis
- Brain Metastases and Treatment
- Chromatin Remodeling and Cancer
- Epigenetics and DNA Methylation
- Neurofibromatosis and Schwannoma Cases
- Angiogenesis and VEGF in Cancer
- Radiomics and Machine Learning in Medical Imaging
- Neuroblastoma Research and Treatments
- Advanced MRI Techniques and Applications
- Vascular Malformations Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Cancer Mechanisms and Therapy
- Mechanisms of cancer metastasis
- Folate and B Vitamins Research
- Pituitary Gland Disorders and Treatments
- Medical Imaging Techniques and Applications
- RNA modifications and cancer
- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
New York University
2016-2025
Hinge Health
2020-2025
NYU Langone Health
2015-2024
NYU Langone’s Laura and Isaac Perlmutter Cancer Center
2016-2020
Neurosciences Institute
2017
Kettering University
2016-2017
Hospital for Sick Children
2016
British Columbia Children's Hospital
2016
New York Audio Productions (United States)
2016
Indiana University School of Medicine
2016
In contrast with the prevailing view that most tumors and metastases begin as avascular masses, evidence is presented here a subset of instead initially grows by coopting existing host vessels. This coopted vasculature does not immediately undergo angiogenesis to support tumor but regresses, leading secondarily massive cell loss. Ultimately, however, remaining rescued robust at margin. The expression patterns angiogenic antagonist angiopoietin-2 pro-angiogenic vascular endothelial growth...
Oncogenic TACC-tics Human cancers exhibit many types of genomic rearrangements—including some that juxtapose sequences from two unrelated genes—thereby creating fusion proteins with oncogenic activity. Functional analysis these genes can provide mechanistic insights into tumorigenesis and potentially lead to effective drugs, as famously illustrated by the BCR-ABL gene in chronic myelogenous leukemia. Singh et al. (p. 1231 , published online 26 July) identify characterize a present 3% human...
PURPOSE: To evaluate the role of T2*-weighted echo-planar perfusion imaging by using a first-pass gadopentetate dimeglumine technique to determine association magnetic resonance (MR) imaging–derived cerebral blood volume (CBV) maps with histopathologic grading astrocytomas and improve accuracy targeting stereotactic biopsy. MATERIALS AND METHODS: MR was performed in 29 patients sequence followed conventional imaging. The data were processed obtain color map relative regional CBV. This...
Hypoxia inducible factor-1 (HIF-1) plays a critical role in angiogenesis during vascular development. The authors tested the hypothesis that HIF-1 expression correlates with progression and brain tumors.The investigated of HIF-1alpha HIF-1beta subunits human glioma cell lines tumor tissues using Western blot analysis immunohistochemistry.In glioblastomas multiforme (GBMs), primarily was localized pseudopalisading cells around areas necrosis infiltrating at margin. In contrast, expressed...
To retrospectively determine whether relative cerebral blood volume (CBV) measurements can be used to predict clinical outcome in patients with high-grade gliomas (HGGs) and low-grade (LGGs) specifically who have a high initial CBV more rapid progression than those low CBV.Approval for this retrospective HIPAA-compliant study was obtained from the Institutional Board of Research Associates, waiver informed consent. One hundred eighty-nine (122 male 67 female patients; median age, 43 years;...
Hypoxia and hypoxia-inducible factor-1 (HIF-1) play a critical role in glioblastoma multiforme (GBMs). CXCR4 is involved angiogenesis upregulated by HIF-1alpha. chemokine receptor for stromal cell-derived (SDF-1)alpha, also known as CXCL12. We hypothesized that would be hypoxia GBMs. First, we investigated the expression of HIF-1alpha was consistently found colocalized with pseudopalisading glioma cells around areas necrosis. In addition, angiogenic tumor vessels were strongly positive...
PATHOLOGICAL AND CLINICAL data from 56 patients operated on for craniopharyngioma since 1981 were analyzed to determine the utility of dividing with this tumor into distinct clinical groups based recognized pathological type and prognostic import brain invasion. Of tumors in 30 adult patients, 66% adamantinomatous, 28% squamous papillary, remainder mixed. However, 26 children, 96% adamantinomatous none pure papillary (P < 0.01). Forty-six percent children compared 17% adults had invasion...
Abstract The poor prognosis of glioblastoma (GBM) routinely treated with ionizing radiation (IR) has been attributed to the relative radioresistance glioma-initiating cells (GIC). Other studies indicate that although GIC are sensitive, response is mediated by undefined factors in microenvironment. GBM produce abundant transforming growth factor-β (TGF-β), a pleotropic cytokine promotes effective DNA damage response. Consistent this, sensitivity, as measured clonogenic assay cultured murine...
Activation of the RAS-RAF-MEK-ERK signaling pathway is thought to be key driver pediatric low-grade astrocytoma (PLGA) growth. Sorafenib a multikinase inhibitor targeting BRAF, VEGFR, PDGFR, and c-kit. This multicenter phase II study was conducted determine response rate sorafenib in patients with recurrent or progressive PLGA. Key eligibility criteria included age ≥2 years, PLGA evaluable on MRI, at least one prior chemotherapy treatment. administered twice daily 200 mg/m2/dose (maximum 400...
Posterior fossa ependymoma comprises two distinct molecular variants termed EPN_PFA and EPN_PFB that have a biology natural history. The therapeutic value of cytoreductive surgery radiation therapy for posterior after accounting subgroup is not known.Four independent nonoverlapping retrospective cohorts ependymomas (n = 820) were profiled using genome-wide methylation arrays. Risk stratification models designed based on known clinical newly described biomarkers identified by multivariable...