A5002259664- Genetic and phenotypic traits in livestock
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Cancer-related gene regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Particle accelerators and beam dynamics
- Lymphoma Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Blood groups and transfusion
- RNA Research and Splicing
- Colorectal Cancer Surgical Treatments
- Fusion materials and technologies
- Garlic and Onion Studies
- Pancreatic and Hepatic Oncology Research
- Enhanced Recovery After Surgery
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neuroendocrine Tumor Research Advances
- Cancer, Lipids, and Metabolism
- Viral-associated cancers and disorders
- Circular RNAs in diseases
- MicroRNA in disease regulation
The Seventh Affiliated Hospital of Sun Yat-sen University
2021-2025
Sun Yat-sen University
2017-2025
Guangxi University
2019-2025
Nanjing Agricultural University
2024
Shandong First Medical University
2023
Shandong Provincial Hospital
2023
State Key Laboratory of Oncogene and Related Genes
2014-2020
Shanghai Jiao Tong University
2011-2020
Shanghai Cancer Institute
2014-2020
Renji Hospital
2011-2020
Small cell lung cancer (SCLC), as a proportion, makes up only 15-17% of cases. The development treatments for SCLC has remained stagnant decades, and is expected to persist threat human health. To date, no publications based on large populations have been reported. We calculated survival changes in patients with during each decade between 1983 2012 determine the roles race, sex, age, socioeconomic status (SES) rates Surveillance, Epidemiology, End Results (SEER) registries. In total, 106,296...
// Ya-Nan Yu 1, 2, * , Ta-Chung Hui-Jun Zhao 1 Tian-Tian Sun Hui-Min Chen Hao-Yan Hui-Fang An 3 Yu-Rong Weng Jun 4 Min Li 5 Wen-Xin Qin 6 Xiong Ma Nan Shen 7 Jie Hong Jing-Yuan Fang State Key Laboratory of Oncogenes and Related Genes, Division Gastroenterology Hepatology, Renji Hospital, School Medicine, Shanghai Jiaotong University, Cancer Institute, Institute Digestive Disease, Shanghai, China 2 Department Gastroenterology, the Affiliated Hospital Qingdao Qingdao, Shandong Province,...
Aberrant arachidonic acid metabolism by cyclooxygenase (COX)-2 and 12-lipoxygenase (LOX) has implicated in carcinogenesis. Genetic polymorphisms COX-2 12-LOX might therefore affect susceptibility to colorectal cancer (CRC). To examine this hypothesis, genotypes of -1290A>G, -1195G>A, -765G>C 261Arg>Gln were determined 1000 CRC patients 1300 controls. Increased risk developing was associated with the -1195GA [adjusted odds ratio (OR) = 1.24, 95% confidence interval (CI) 1.00-1.54] -1195AA...
Objective: The E3 ubiquitin ligase RNF6 (RING-finger protein 6) plays a crucial role in carcinogenesis. However, the copy number and expression of were rarely reported colorectal cancer. We aimed to explore mechanical, biological, clinical cancer initiation progression.Design: analyzed from Tumorscape Cancer Genome Atlas (TCGA) datasets. Gene expressions examined by real-time PCR, Western blot, immunohistochemical staining. profiling studies performed identify pivotal genes regulated RNF6....
Background: Synovial sarcoma (SyS) is a rare malignancy that typically invades the extremities and occurs predominantly in adolescents.Studies on incidence survival SyS were based large population had not been reported yet.Methods: To evaluate changes over three decades, we accessed data cases each decade between 1983 2012 (1983-1992, 1993-2002, 2003-2012) from Surveillance, Epidemiology, End Results (SEER) database.The difference age groups, sexes, race, pathologic types, sites, stages...
The role of programmed cell death ligand 1 (PD-L1) in non-small lung cancer (NSCLC), especially according to histologic type, remains controversial. purpose this study was assess PD-L1 expression and its association with overall survival (OS) clinicopathologic characteristics NSCLC.Formalin-fixed paraffin-embedded specimens were obtained from 108 patients surgically resected primary NSCLC. assessed via immunohistochemistry using a histochemistry score system. relationship between OS or...
Abstract During follicular development, a series of key events such as recruitment and selection are crucially governed by strict complex regulation. However, its molecular mechanisms remain obscure. To identify the dominant genes controlling chicken small white follicle (SWF), yellow (SYF), large (LYF) in different laying stages (W22, W31, W51) were collected for RNA sequencing bioinformatics analysis. There 1866, 1211, 1515 differentially expressed (DEGs) between SWF SYF W22, W51,...
The role and clinical implication of the transmembrane protein with EGF two follistatin motifs 2 (TMEFF2) in gastric cancer is poorly understood.Gene expression profile analyses were performed Gene Set Enrichment Analysis (GSEA) was used to explore its gene signatures. AGS MKN45 cells transfected TMEFF2 or control plasmids analyzed for patterns, proliferation, apoptosis. knocked down shRNAs, effects on genome stability assessed. Interactions between SHP-1 determined by mass spectrometry...
Feed efficiency is an important economic factor in poultry production, and the rate of feed generally evaluated using residual intake (RFI). The molecular regulatory mechanisms RFI remain unknown. Therefore, objective this study was to identify candidate genes signaling pathways related RNA-sequencing for low (LRFI) high (HRFI) Xiayan chicken, a native chicken Guangxi province. Chickens were divided into four groups based on FE sex: LRFI HRFI males females, respectively. We identified total...
Fat deposition is a vital factor affecting the economics of poultry production. Numerous studies on fat have been done. However, molecular regulatory mechanism still unclear. In present study, whole-transcriptome RNA sequencing in abdominal fat, back skin, and liver both high- low-abdominal groups was used to uncover competitive endogenous (ceRNA) regulation network related chicken deposition. The results showed that differentially expressed (DE) genes were 1207(784 mRNAs, 330 lncRNAs, 41...
Background XKH001 is a recombinant humanized IgG1 monoclonal antibody against IL-25 for the treatment of type 2 inflammatory diseases. This study aimed to evaluate tolerability, pharmacokinetics, and pharmacodynamics in humans first time.
Multiple myeloma (MM) is estimated to have 30,280 new cases and be associated with 12,590 deaths in 2017. However, quantitative analysis for survival, based on a large population, lacking. Data were extracted from total of 33,170 nine registry sites the Surveillance, Epidemiology, End Results database. The current study shows that incidence MM remained relatively stable between 1981 2010, 4.6, 4.7, 4.7 per 100,000 persons each decade. In addition, survival improved decade larger increment...
Abstract Background Splicing factor SRSF3 is an oncogene and overexpressed in various kinds of cancers, however, the function mechanism involved colorectal cancer (CRC) remained unclear. The aim this study was to explore relationship between carcinogenesis progression CRC. Methods expression CRC tissues detected by immunohistochemistry. proliferation invasion rate analyzed CCK-8 assay, colony formation transwell assay xenograft experiment. selected genes western blot or real time PCR....
Non–small cell lung cancer is the most common malignancy in males; it constitutes majority of cases and requires massive medical resources. Despite improvements managing non–small cancer, long-term survival remains very low. This study evaluated improvement patients with each decade between 1983 2012 to determine impact race, sex, age, socioeconomic status on rates these patients. We extracted data from Surveillance, Epidemiology, End Results registries. In total, 573,987 were identified 18...
Although several prognostic signatures have been developed for gastric cancer (GC), the utility of these tools is limited in clinical practice due to lack validation with large and multiple independent cohorts, or a statistical test determine robustness predictive models. Here, signature was constructed using least absolute shrinkage selection operator (LASSO) Cox regression model training dataset 300 GC patients. The verified three datasets total 658 tumors across multiplatforms. A nomogram...
Background One of the most prevalent hematological system cancers is acute myeloid leukemia (AML). Efferocytosis-related genes (ERGs) and N6-methyladenosine (m6A) have an important significance in progression cancer, metastasis tumors. Methods The AML-related data were collected from Cancer Genome Atlas (TCGA; TCGA-AML) database Gene Expression Omnibus (GEO; GSE9476, GSE71014, GSE13159) database. “limma” R package Venn diagram adopted to identify differentially expressed ERGs (DE-ERGs). m6A...
Abstract Background Long-term survival rates for patients with stage III–IV Hodgkin lymphoma, or advanced lymphoma (aHL), have increased substantially since the 1960s. Because large-scale research of aHL is rare, we aimed to demonstrate differences in incidence and according four patient variables recent decades, a focus on outcomes treatment advancement public health care. Materials Methods Data cases diagnosed during 1984–2013 were extracted from Surveillance, Epidemiology, End Results...
We aimed to develop an HCC classification model based on the integrated gene expression and methylation data of methylation-driven genes. Genome, methylome, transcriptome, proteomics clinical 369 patients from The Cancer Genome Atlas Network were retrieved analyzed. Consensus clustering genes identified 4 subclasses with significant prognosis difference. HS1 was well differentiated a favorable prognosis. HS2 had high serum α-fetoprotein level that correlated its poor outcome. High percentage...
Pancreatic neuroendocrine neoplasm (pNEN), with the lowest 5-year survival rates in tumors (NETs), exerts great threat to human health. Because large-scale population research aimed at pNEN is rare, we explore tendencies and differences of changes incidences each decade from 1987 2016 evaluate impacts age, sex, race, socioeconomic status (SES), grade. Data on cases were extracted Surveillance, Epidemiology, End Results Program (SEER) database. Kaplan-Meier, Cox proportional hazards...