A5100740523- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Osteoarthritis Treatment and Mechanisms
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- Advanced MRI Techniques and Applications
- Advances in Oncology and Radiotherapy
- Ferroptosis and cancer prognosis
- COVID-19 and healthcare impacts
- Cancer-related cognitive impairment studies
- Sinusitis and nasal conditions
- Cancer-related Molecular Pathways
- Pain Mechanisms and Treatments
- Delphi Technique in Research
- Gait Recognition and Analysis
- Human Pose and Action Recognition
- Asthma and respiratory diseases
- Acupuncture Treatment Research Studies
- Brain Tumor Detection and Classification
- Drug Transport and Resistance Mechanisms
- Pregnancy-related medical research
- Neurofibromatosis and Schwannoma Cases
- Wnt/β-catenin signaling in development and cancer
- PI3K/AKT/mTOR signaling in cancer
Huashan Hospital
2018-2025
Fudan University
2018-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2020-2025
Shandong Provincial Hospital
2019-2024
Shandong First Medical University
2022-2024
Ministry of Education of the People's Republic of China
2023
Anhui Medical University
2023
Center for Excellence in Brain Science and Intelligence Technology
2022
Shanxi Medical University
2021
Shanghai Clinical Research Center
2021
Pathological diagnosis of glioma subtypes is essential for treatment planning and prognosis. Standard histological based on postoperative hematoxylin eosin stained slides by neuropathologists. With advancing artificial intelligence (AI), the aim this study was to determine whether deep learning can be applied classification.
Glioblastoma is the most common and fatal primary brain tumor in adults. Even with maximal resection a series of postoperative adjuvant treatments, median overall survival (OS) glioblastoma patients remains approximately 15 months. The Huashan Hospital glioma bank contains more than 2000 tissue samples long-term follow-up data; almost half these are from patients. Several large databases data have reported outcomes countries other China. We investigated prognosis China compared among...
Abstract Cyclic cGMP-AMP synthase (cGAS) is a pattern recognition cytosolic DNA sensor that essential for cellular senescence. cGAS promotes inflammatory senescence-associated secretory phenotype (SASP) through recognizing cytoplasmic chromatin during cGAS-mediated inflammation the antitumor effects of immune checkpoint blockade. However, mechanism by which recognizes unknown. Here we show topoisomerase 1-DNA covalent cleavage complex (TOP1cc) both necessary and sufficient SASP TOP1cc...
OBJECTIVE Insular lobe gliomas continue to challenge neurosurgeons due their complex anatomical position. Transcortical and transsylvian corridors remain the primary approaches for reaching insula, but adoption of one technique over other remains controversial. The authors analyzed transcortical approach resecting insular in context patient tumor location based on Berger-Sinai classification, achievable extents resection (EORs), overall survival (OS), postsurgical neurological outcome....
Triple-negative breast cancer (TNBC) is the most aggressive type of cancer. Currently, targeting therapy makes great advances for treatment TNBC, whereas more effective therapeutic targets are urgently needed. Cyclin B2 (CCNB2), which belongs to B-type cyclins, known as a cell cycle regulator. CCNB2 synthesized at G1 phase in cells and downregulated anaphase. The defects led abnormal tumorigenesis. Though there wide effects on multiple types tumors, potential role TNBC progression still...
Glioma undergoes adaptive changes, leading to poor prognosis and resistance treatment. CD99 influences the migration invasion of glioma cells plays an oncogene role. However, whether can affect adaptiveness gliomas is still lacking in research, making its clinical value underestimated. Here, we enrolled our in-house public multiomics datasets for bioinformatic analysis conducted immunohistochemistry staining investigate role response implications. expressed more adaptative subtypes cell...
Abstract Backgrounds Glioma research has increasingly emphasized quality of life alongside traditional survival metrics, emphasizing functional outcomes, symptom burden, and social reintegration, including the ability to work. While previous studies focused on return-to-work rates, we assessed general work as a broader measure capacity. We aimed develop predictive models for recovery, identify key risk factors, explore long-term trajectories. Methods conducted retrospective cohort study 342...
Abstract Background Glioma is the most common primary brain tumor with high mortality and disability rates. Recent studies have highlighted significant prognostic consequences of subtyping molecular pathological markers using samples, such as IDH, 1p/19q, TERT. However, relative importance individual or marker combinations in affecting patient survival remains unclear. Moreover, cost reliance on postoperative samples hinder widespread use these clinical practice, particularly during...
The medical community has expressed significant interest in the treatment of cartilage defect. Successful repair articular defects remains a challenge clinics. Due to huge advantages 3D micro/nanomaterials, artificial micro/nano scaffolds have been widely developed and explored tissue joints. In this study, chondrocyte/osteoblast-loaded β-tricalcium phosphate (β-TCP) bioceramic scaffold chondrocyte-loaded β-TCP were prepared by micromass stem cell culture bioreactor-based cells-loaded for...
Tuina is a traditional Chinese treatment for sensory disturbances caused by peripheral nerve injury and related diseases. Our previous studies showed that tuina regulates relevant regions indices of the spinal dorsal horn using Dian, Bo, Rou method in Yinmen (BL37), Yanglingquan (GB34), Weizhong (BL40). Treatment prevents muscle atrophy, protects cord neurons, promotes sciatic repair. The mechanisms action treating remain poorly understood. This study established rat models crushing method....
Abstract Background: We conduct this randomized controlled trial protocol for the comparison of influence hydrocolloid dressing and polyurethane foam in treatment pressure ulcers (PUs) patients. Methods: This study will be implemented from February 2021 to 2022 at Hangzhou Geriatric Hospital. The experiment was granted through Research Ethics Committee Hospital (C5259033). Criteria inclusion: patients older than 18 years age who have been diagnosed with PU. If patient suffers more a PU, only...
Abstract Background The Coronavirus disease 2019 (COVID-19) pandemic has extraordinarily impacted global healthcare. Neuro-oncological surgery units have peculiar features that make them highly relevant in the strategic reaction to pandemic. In this Chinese Society of Neuro-Oncology (CSNO) initiated survey, we appraise changes implemented neuro-oncological hospitals across different Asian countries and provide expert recommendations for responses at stages Methods We performed a 42-question...
While maximizing extent of resection (EOR) is associated with longer survival in lower-grade glioma (LGG) patients, the number cases remains insufficient determining a EOR threshold to elucidate clinical benefits, especially IDH-wild-type LGG patients.To identify effects on outcomes patients.IDH-wild-type patients were retrospectively reviewed. The effect and other predictor variables overall (OS) progression-free (PFS) was analyzed using Cox regression models Kaplan-Meier method.A total 94...